{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,11]],"date-time":"2026-06-11T12:57:10Z","timestamp":1781182630238,"version":"3.54.1"},"reference-count":21,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2012,2,6]],"date-time":"2012-02-06T00:00:00Z","timestamp":1328486400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2012,2,6]],"date-time":"2012-02-06T00:00:00Z","timestamp":1328486400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Int J Immunogenetics"],"published-print":{"date-parts":[[2012,8]]},"abstract":"<jats:title>Summary<\/jats:title>\n                  <jats:p>\n                    The aim of this study was to evaluate the effect of the TLR\u20104 gene TLR4 c.896A&lt;G polymorphism on the development and clinical severity of urinary tract infections (UTI) and renal scar formations in children. The patients with first diagnosis of UTI (\n                    <jats:italic>n<\/jats:italic>\n                    \u2003=\u2003112) and healthy controls (\n                    <jats:italic>n<\/jats:italic>\n                    \u2003=\u200393) were enrolled in the study. The TLR4 c.896A&lt;G polymorphism was analysed in groups. The mean age of the patients in the study group was 8.1\u2003\u00b1\u20033.5\u2003years and 9.2\u2003\u00b1\u20032.7\u2003years for those in the control group. The TLR4 c.896A&lt;G polymorphism was detected in 12.5% in the UTI group and in 15.1% of the control group. Forty patients showed pyelonephritis (PN) with scar tissue, 37 patients had PN without scars, and 35 patients had lower UTI. The TLR4 c.896A&lt;G polymorphism was found in 22.5% of patients with scar\u2010positive PN, and it was also present in 10.8% of patients with scar\u2010negative PN and 2.9% of patients with lower UTI. We found higher TLR4 c.896A&lt;G polymorphism and allelic frequency in patients with upper UTI compared to patients with lower UTI (\n                    <jats:italic>P\u2003<\/jats:italic>\n                    =\u20030.041 and\n                    <jats:italic>P\u2003<\/jats:italic>\n                    =\u20030.039, respectively). No significant difference was observed between patients and the control group for TLR\u20104 c.896A3. The TLR4 c.896A&lt;G polymorphism and alleles were higher in patients with upper UTI than in patients with lower UTI. The TLR4 c.896A&lt;G polymorphism frequency was nearly twice that in the scar\u2010positive PN patients when compared to the scar\u2010negative patients. Larger\u2010scale studies involving larger numbers of patients should be performed.\n                  <\/jats:p>","DOI":"10.1111\/j.1744-313x.2012.01090.x","type":"journal-article","created":{"date-parts":[[2012,2,6]],"date-time":"2012-02-06T08:41:45Z","timestamp":1328517705000},"page":"303-307","source":"Crossref","is-referenced-by-count":29,"title":["Assessment of Toll\u2010like receptor\u20104 gene polymorphism on pyelonephritis and renal scar"],"prefix":"10.1111","volume":"39","author":[{"given":"I.","family":"Akil","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F.","family":"Ozkinay","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H.","family":"Onay","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.","family":"Canda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G.","family":"Gumuser","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Kavukcu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2012,2,6]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1086\/344893"},{"key":"e_1_2_6_3_1","first-page":"187","article-title":"TLR\u20104 mutations are associated with endotoxin hyporesponsiveness in humans","volume":"25","author":"Arbour 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