{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,11]],"date-time":"2026-06-11T12:57:03Z","timestamp":1781182623372,"version":"3.54.1"},"reference-count":53,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2012,2,2]],"date-time":"2012-02-02T00:00:00Z","timestamp":1328140800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2012,2,2]],"date-time":"2012-02-02T00:00:00Z","timestamp":1328140800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Int J Immunogenetics"],"published-print":{"date-parts":[[2012,8]]},"abstract":"<jats:title>Summary<\/jats:title>\n                  <jats:p>\n                    Invasive infection caused by\n                    <jats:italic>Neisseria meningitidis<\/jats:italic>\n                    is a worldwide public health problem. Previous reports have indicated that carriage of common \u2018defective\u2019 structural polymorphisms of the host mannose\u2010binding lectin gene (\n                    <jats:italic>MBL2<\/jats:italic>\n                    ) greatly increases an individual\u2019s risk of developing the disease. We report the largest case\u2013control study so far to investigate the effect of these polymorphisms in meningococcal disease (296 PCR\u2010positive cases and 5196 population controls, all of European ancestry) and demonstrate that no change in risk is associated with the polymorphisms overall or in any age\u2010defined subgroup. This finding contrasts with two smaller studies that reported an increase in risk. A systematic review of all studies of\n                    <jats:italic>MBL2<\/jats:italic>\n                    polymorphisms in people of European ancestry published since 1999, including 24\u2003693 individuals, revealed a population frequency of the combined \u2018defective\u2019\n                    <jats:italic>MBL2<\/jats:italic>\n                    allele of 0.230 (95% confidence limits: 0.226\u20130.234). The past reported associations of increased risk of meningococcal disease were because of low \u2018defective\u2019 allele frequencies in their study control populations (0.13 and 0.04) that indicate systematic problems with the studies. The data from our study and all other available evidence indicate that\n                    <jats:italic>MBL2<\/jats:italic>\n                    structural polymorphisms do not predispose children or adults to invasive meningococcal disease.\n                  <\/jats:p>","DOI":"10.1111\/j.1744-313x.2012.01095.x","type":"journal-article","created":{"date-parts":[[2012,2,2]],"date-time":"2012-02-02T04:57:36Z","timestamp":1328158656000},"page":"328-337","source":"Crossref","is-referenced-by-count":18,"title":["Genetic susceptibility to invasive meningococcal disease:\n                    <i>MBL2<\/i>\n                    structural polymorphisms revisited in a large case\u2013control study and a systematic review"],"prefix":"10.1111","volume":"39","author":[{"given":"D. T.","family":"Bradley","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T. 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