{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,28]],"date-time":"2025-09-28T08:30:36Z","timestamp":1759048236987},"reference-count":12,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2012,7,26]],"date-time":"2012-07-26T00:00:00Z","timestamp":1343260800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Int J Immunogenetics"],"published-print":{"date-parts":[[2013,4]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>We report here the novel variant of <jats:styled-content style=\"fixed-case\">HLA<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">DRB<\/jats:styled-content>1*09:01, <jats:styled-content style=\"fixed-case\">DRB<\/jats:styled-content>1*09:01:08, discovered in a Taiwanese volunteer bone marrow donor by a sequence\u2010based typing (<jats:styled-content style=\"fixed-case\">SBT<\/jats:styled-content>) method. The <jats:styled-content style=\"fixed-case\">DNA<\/jats:styled-content> sequence of <jats:styled-content style=\"fixed-case\">DRB<\/jats:styled-content>1*09:01:08 is identical to the sequence of <jats:styled-content style=\"fixed-case\">DRB<\/jats:styled-content>1*09:01:02 in exon 2 except a silent mutation at nucleotide position 261(<jats:styled-content style=\"fixed-case\">C<\/jats:styled-content>\u2192<jats:styled-content style=\"fixed-case\">T<\/jats:styled-content>) (<jats:styled-content style=\"fixed-case\">GCC<\/jats:styled-content>\u2192<jats:styled-content style=\"fixed-case\">GCT<\/jats:styled-content> at codon 58). We hypothesize <jats:styled-content style=\"fixed-case\">DRB<\/jats:styled-content>1*09:01:08 was probably derived from <jats:styled-content style=\"fixed-case\">DRB<\/jats:styled-content>1*09:01:02 via a nucleotide point mutation event. The plausible <jats:styled-content style=\"fixed-case\">HLA<\/jats:styled-content>\u2010A, <jats:styled-content style=\"fixed-case\">HLA<\/jats:styled-content>\u2010B and <jats:styled-content style=\"fixed-case\">HLA<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">DRB<\/jats:styled-content>1 haplotype in association with <jats:styled-content style=\"fixed-case\">DRB<\/jats:styled-content>1*09:01:08 was deduced as <jats:styled-content style=\"fixed-case\">A<\/jats:styled-content>*02:07\u2010<jats:styled-content style=\"fixed-case\">B<\/jats:styled-content>*46:01\u2010<jats:styled-content style=\"fixed-case\">DRB<\/jats:styled-content>1*09:01:08.<\/jats:p>","DOI":"10.1111\/j.1744-313x.2012.01143.x","type":"journal-article","created":{"date-parts":[[2012,7,26]],"date-time":"2012-07-26T08:27:03Z","timestamp":1343291223000},"page":"149-150","source":"Crossref","is-referenced-by-count":4,"title":["Discovery of the novel <scp>HLA<\/scp>\u2010<scp>DRB<\/scp>1*09:01:08 allele in a <scp>T<\/scp>aiwanese volunteer bone marrow donor and identification of the probable <scp>HLA<\/scp>\u2010<scp>A<\/scp>,<scp> HLA<\/scp>\u2010<scp>B<\/scp> and <scp>HLA<\/scp>\u2010<scp>DRB<\/scp>1 haplotype in association with <scp>DRB<\/scp>1*09:01:08"],"prefix":"10.1111","volume":"40","author":[{"given":"K. L.","family":"Yang","sequence":"first","affiliation":[{"name":"Laboratory of Immunogenetics and Cord Blood Bank Buddhist Tzu Chi Stem Cells Centre and Marrow Donor Registry Buddhist Tzu Chi General Hospital Buddhist Compassion Relief Tzu Chi Foundation Hualien Taiwan"},{"name":"Department of Medical Biotechnology Buddhist Compassion Relief Tzu Chi Foundation Buddhist Tzu Chi University Hualien Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S. K.","family":"Lee","sequence":"additional","affiliation":[{"name":"Laboratory of Immunogenetics and Cord Blood Bank Buddhist Tzu Chi Stem Cells Centre and Marrow Donor Registry Buddhist Tzu Chi General Hospital Buddhist Compassion Relief Tzu Chi Foundation Hualien Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S. Y.","family":"Yang","sequence":"additional","affiliation":[{"name":"Laboratory of Immunogenetics and Cord Blood Bank Buddhist Tzu Chi Stem Cells Centre and Marrow Donor Registry Buddhist Tzu Chi General Hospital Buddhist Compassion Relief Tzu Chi Foundation Hualien Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R. H.","family":"Kao","sequence":"additional","affiliation":[{"name":"Laboratory of Immunogenetics and Cord Blood Bank Buddhist Tzu Chi Stem Cells Centre and Marrow Donor Registry Buddhist Tzu Chi General Hospital Buddhist Compassion Relief Tzu Chi Foundation Hualien Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C. L.","family":"Lin","sequence":"additional","affiliation":[{"name":"Laboratory of Immunogenetics and Cord Blood Bank Buddhist Tzu Chi Stem Cells Centre and Marrow Donor Registry Buddhist Tzu Chi General Hospital Buddhist Compassion Relief Tzu Chi Foundation Hualien Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P. Y.","family":"Lin","sequence":"additional","affiliation":[{"name":"Laboratory of Immunogenetics and Cord Blood Bank Buddhist Tzu Chi Stem Cells Centre and Marrow Donor Registry Buddhist Tzu Chi General Hospital Buddhist Compassion Relief Tzu Chi Foundation Hualien Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2012,7,26]]},"reference":[{"key":"e_1_2_3_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1744-313X.2007.00690.x"},{"key":"e_1_2_3_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1744-313X.2007.00731.x"},{"key":"e_1_2_3_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1744-313X.2008.00827.x"},{"key":"e_1_2_3_5_1","first-page":"263","article-title":"Rare HLA alleles and their predicted haplotypes in Tzu Chi Taiwanese Marrow Donor Registry","volume":"38","author":"Chen M.J.","year":"2010","journal-title":"International Journal of Immunogenetics"},{"key":"e_1_2_3_6_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkq1128"},{"key":"e_1_2_3_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.humimm.2010.05.013"},{"key":"e_1_2_3_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-0039.2010.01466.x"},{"key":"e_1_2_3_9_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkq998"},{"key":"e_1_2_3_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.humimm.2008.05.012"},{"key":"e_1_2_3_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1744-313X.2007.00704.x"},{"key":"e_1_2_3_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.humimm.2009.01.015"},{"key":"e_1_2_3_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1744-313X.2010.00992.x"}],"container-title":["International Journal of Immunogenetics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1744-313X.2012.01143.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1744-313X.2012.01143.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,30]],"date-time":"2023-10-30T10:23:17Z","timestamp":1698661397000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1744-313X.2012.01143.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,7,26]]},"references-count":12,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2013,4]]}},"alternative-id":["10.1111\/j.1744-313X.2012.01143.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1744-313x.2012.01143.x","archive":["Portico"],"relation":{},"ISSN":["1744-3121","1744-313X"],"issn-type":[{"value":"1744-3121","type":"print"},{"value":"1744-313X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,7,26]]}}}