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Here, we characterize the message and protein expression profiles of yellow fever mosquito (<jats:italic>Aedes aegypti<\/jats:italic>) ferritin heavy chain homologue (<jats:styled-content style=\"fixed-case\">HCH<\/jats:styled-content>) and light chain homologue (<jats:styled-content style=\"fixed-case\">LCH<\/jats:styled-content>) subunits in response to iron and bacterial challenge. <jats:italic>In vivo<\/jats:italic> experiments demonstrated tissue\u2010specific regulation of <jats:styled-content style=\"fixed-case\">HCH<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">LCH<\/jats:styled-content> expression over time post\u2010blood meal (<jats:styled-content style=\"fixed-case\">PBM<\/jats:styled-content>). Transcriptional regulation of <jats:italic><jats:styled-content style=\"fixed-case\">HCH<\/jats:styled-content><\/jats:italic> and <jats:italic><jats:styled-content style=\"fixed-case\">LCH<\/jats:styled-content><\/jats:italic> was treatment specific, with differences in regulation for na\u00efve versus mosquitoes challenged with heat\u2010killed bacteria (<jats:styled-content style=\"fixed-case\">HKB<\/jats:styled-content>). Translational regulation by iron regulatory protein (<jats:styled-content style=\"fixed-case\">IRP<\/jats:styled-content>) binding activity for the iron\u2010responsive element (<jats:styled-content style=\"fixed-case\">IRE<\/jats:styled-content>) was tissue\u2010specific and time\u2010dependent <jats:styled-content style=\"fixed-case\">PBM<\/jats:styled-content>. However, mosquitoes challenged with <jats:styled-content style=\"fixed-case\">HKB<\/jats:styled-content> showed little change in <jats:styled-content style=\"fixed-case\">IRP<\/jats:styled-content>\/<jats:styled-content style=\"fixed-case\">IRE<\/jats:styled-content> binding activity compared to na\u00efve animals. The changes in ferritin regulation and expression <jats:italic>in vivo<\/jats:italic> were confirmed with <jats:italic>in vitro<\/jats:italic> studies. We challenged mosquitoes with <jats:styled-content style=\"fixed-case\">HKB<\/jats:styled-content> followed by a blood meal to determine the effects on ferritin expression, and demonstrate a synergistic, time\u2010dependent regulation of expression for <jats:styled-content style=\"fixed-case\">HCH<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">LCH<\/jats:styled-content>.<\/jats:p>","DOI":"10.1111\/j.1744-7917.2012.01581.x","type":"journal-article","created":{"date-parts":[[2012,10,17]],"date-time":"2012-10-17T06:26:05Z","timestamp":1350455165000},"page":"601-619","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["The effect of bacterial challenge on ferritin regulation in the yellow fever mosquito, <i>Aedes aegypti<\/i>"],"prefix":"10.1111","volume":"20","author":[{"given":"Dawn L.","family":"Geiser","sequence":"first","affiliation":[{"name":"Department of Nutritional Sciences, College of Agriculture and Life Sciences, the University of Arizona  Tucson Arizona 85721 USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guoli","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Nutritional Sciences, College of Agriculture and Life Sciences, the University of Arizona  Tucson Arizona 85721 USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jonathan J.","family":"Mayo","sequence":"additional","affiliation":[{"name":"Department of Nutritional Sciences, College of Agriculture and Life Sciences, the University of Arizona  Tucson Arizona 85721 USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joy J.","family":"Winzerling","sequence":"additional","affiliation":[{"name":"Department of Nutritional Sciences, College of Agriculture and Life Sciences, the University of Arizona  Tucson Arizona 85721 USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2012,12,11]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ibmb.2004.03.019"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ibmb.2009.01.007"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1139\/m79-124"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.72.7.4114-4126.2004"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2583.2007.00773.x"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1193162"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1101\/gr.1865504"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1093\/embo-reports\/kvf180"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/0003-2697(76)90527-3"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.95.26.15235"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ibmb.2006.08.010"},{"key":"e_1_2_7_13_1","first-page":"743","article-title":"Control efficacy of Trichogramma japonicum against Chilo suppressalis and Chilaraea auricilia","volume":"21","author":"Chen H.F.","year":"2010","journal-title":"Journal of Applied Ecology"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0965-1748(97)00017-9"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/0965-1748(95)00108-5"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.0105-2896.2004.0127.x"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.97.12.6619"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0952-7915(00)00186-2"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.actatropica.2008.01.001"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.0020052"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0965-1748(99)00130-7"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1089\/104454999314791"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2583.2000.00212.x"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.nutr.20.1.627"},{"key":"e_1_2_7_25_1","doi-asserted-by":"crossref","first-page":"27363","DOI":"10.1016\/S0021-9258(19)74258-6","article-title":"Iron\u2010responsive element\u2010binding protein. 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