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Twelve patients of Fontaine stage III\u2010IV were treated with a series of 10 Rheopheresis sessions over 17\u2003weeks. Transcutaneous oxygen pressure (tcpO<jats:sub>2<\/jats:sub>) and ankle\u2010brachial index (ABI) were repeatedly determined to monitor the effects of the Rheopheresis treatment series on microcirculation and skin blood flow. Laboratory parameters of blood rheology were measured in addition to safety parameters and course of the pain syndrome was documented. In four patients (baseline Fontaine stage III) Rheopheresis was associated with an improvement of Fontaine stage, a pronounced increase in tcpO<jats:sub>2<\/jats:sub> and complete regression of the rest pain. As an adjunct therapeutic option, Rheopheresis may preserve a functional lower extremity, delay amputation or reduce the extent of amputation.<\/jats:p>","DOI":"10.1111\/j.1744-9987.2005.00276.x","type":"journal-article","created":{"date-parts":[[2005,12,15]],"date-time":"2005-12-15T10:01:52Z","timestamp":1134640912000},"page":"473-481","source":"Crossref","is-referenced-by-count":29,"title":["Rheopheresis in Patients with Critical Limb Ischemia\u2013\u2013Results of an Open Label Prospective Pilot Trial"],"prefix":"10.1111","volume":"9","author":[{"given":"Reinhard","family":"Klingel","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bernard","family":"Erdtracht","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Victor","family":"Gauss","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andreas","family":"Piazolo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrick","family":"Mausfeld\u2010Lafdhiya","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Curt","family":"Diehm","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2005,12,15]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1002\/clc.4950250103"},{"key":"e_1_2_6_3_2","first-page":"525","article-title":"Management of peripheral arterial disease","volume":"69","author":"Lesho EP","year":"2004","journal-title":"Am Fam Physician"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1191\/1358863x04vm525oa"},{"key":"e_1_2_6_5_2","first-page":"3","article-title":"Impaired plasma viscosity via increased cholesterol levels in peripheral occlusive arterial disease","volume":"29","author":"Ercan M","year":"2003","journal-title":"Clin Hemorheol Microcir"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.2337\/diacare.26.12.3333"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(76)92778-1"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.94.11.3026"},{"key":"e_1_2_6_9_2","first-page":"1","article-title":"Management of peripheral arterial disease","volume":"31","author":"Trans Atlantic Inter\u2010Society Consensus (TASC) Working Group.","year":"2000","journal-title":"J Vasc Surg"},{"key":"e_1_2_6_10_2","first-page":"93","article-title":"Predictors of clinical outcome in critical leg ischaemia","volume":"11","author":"Bertele V","year":"2001","journal-title":"Crit Ischaemia"},{"key":"e_1_2_6_11_2","first-page":"50","article-title":"Fate of the patient with chronic leg ischaemia. 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