{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T15:45:57Z","timestamp":1759333557573},"reference-count":6,"publisher":"Wiley","issue":"s1","license":[{"start":{"date-parts":[[2005,8,17]],"date-time":"2005-08-17T00:00:00Z","timestamp":1124236800000},"content-version":"vor","delay-in-days":16,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Ther Apher Dial"],"published-print":{"date-parts":[[2005,8]]},"abstract":"<jats:p><jats:bold>Abstract:\u2002<\/jats:bold> Abnormalities of mineral metabolism, including those of calcium (Ca), phosphorus (P), and parathyroid hormone (PTH) in patients on maintenance hemodialysis induce severe bone involvement, which manifests as renal osteodystrophy. Recently, vascular calcification caused by abnormal mineral metabolism has been attracting attention because cardiovascular diseases (CVD) are a major cause of death in hemodialysis patients. Since 2000, the treatment standard for overt secondary hyperparathyroidism (SHPT) in our facilities has shifted from conventional or pulse therapy with oral vitamin D3 (VitD) to intravenous pulse therapy with maxacalcitriol or calcitriol. After selecting the criterion of overt SHPT as intact\u2010PTH\u2003&gt;\u2003500\u2003pg\/mL, the proportion of overt SHPT cases among all hemodialysis patients decreased from 12% at the start of intravenous pulse treatment to 6.4% after 4 years\u2019 treatment. However, the number of patients who had an interruption to pulse treatment because of hypercalcemia and\/or hyperphosphatemia was high and it became a bottleneck for the continuation of the therapy. The major cause of hypercalcemia is considered to be Ca load derived from oral calcium carbonate. In Japan, sevelamer hydrochrolide (SH), which does not contain Ca, has been available commercially since 2003 and potentially should enable a reduction in the incidence of overt SHPT during long\u2010term intravenous treatment when combined with careful adjustment of the dose of VitD and strict monitoring of Ca and P level concentrations. In this study, we found that the proportion of patients who satisfy the recommended serum concentrations of Ca and P reported by K\/DOQI guideline was low irrespective of the serum concentration of intact\u2010PTH. The aortic calcification index was high in the patient group with lower intact\u2010PTH level concentration, probably because of reduced Ca and P buffering ability associated with reduced bone turnover. We consider that VitD treatment with SH might give better control of the intact\u2010PTH level concentration within the range recommended by the K\/DOQI guideline.<\/jats:p>","DOI":"10.1111\/j.1744-9987.2005.00325.x","type":"journal-article","created":{"date-parts":[[2005,8,17]],"date-time":"2005-08-17T07:15:45Z","timestamp":1124262945000},"source":"Crossref","is-referenced-by-count":3,"title":["Management of Calcium, Phosphorus and Bone Metabolism in Dialysis Patients Using Sevelamer Hydrochloride and Vitamin D Therapy"],"prefix":"10.1111","volume":"9","author":[{"given":"Mari","family":"Ishida","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Naoyuki","family":"Yao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Setsuko","family":"Yachiku","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tsutomu","family":"Anzai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takeshi","family":"Kobayashi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hironori","family":"Ishida","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,8,17]]},"reference":[{"key":"e_1_2_5_2_2","first-page":"385","article-title":"Effect of long term intravenous calcitriol on secondary hyperparathyroidism in hemodialysis patients in period of 52 weeks treatment","volume":"57","author":"Ishida M","year":"2004","journal-title":"Jin to Touseki"},{"key":"e_1_2_5_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0272-6386(03)00905-3"},{"key":"e_1_2_5_4_2","doi-asserted-by":"publisher","DOI":"10.1053\/ajkd.2002.33400"},{"key":"e_1_2_5_5_2","first-page":"98","article-title":"Ca and VitD derivative on stage of renal failure","volume":"13","author":"Ubara Y","year":"2003","journal-title":"Clin Calcium"},{"key":"e_1_2_5_6_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1523-1755.2002.00372.x"},{"key":"e_1_2_5_7_2","first-page":"1589","article-title":"Effect of intravenous VitD pulse therapy with sevelamer hydrochloride for secondary hyperparathyroidism in hemodialyasis patients","volume":"20","author":"Ishida M","year":"2004","journal-title":"Rinshou Touseki"}],"container-title":["Therapeutic Apheresis and Dialysis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1744-9987.2005.00325.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1744-9987.2005.00325.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,27]],"date-time":"2023-09-27T06:28:00Z","timestamp":1695796080000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1744-9987.2005.00325.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005,8]]},"references-count":6,"journal-issue":{"issue":"s1","published-print":{"date-parts":[[2005,8]]}},"alternative-id":["10.1111\/j.1744-9987.2005.00325.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1744-9987.2005.00325.x","archive":["Portico"],"relation":{},"ISSN":["1744-9979","1744-9987"],"issn-type":[{"value":"1744-9979","type":"print"},{"value":"1744-9987","type":"electronic"}],"subject":[],"published":{"date-parts":[[2005,8]]}}}