{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,2]],"date-time":"2026-04-02T10:06:34Z","timestamp":1775124394800,"version":"3.50.1"},"reference-count":37,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2006,6,30]],"date-time":"2006-06-30T00:00:00Z","timestamp":1151625600000},"content-version":"vor","delay-in-days":29,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Ther Apher Dial"],"published-print":{"date-parts":[[2006,6]]},"abstract":"<jats:p><jats:bold>Abstract:\u2002<\/jats:bold> Although it is known that LDL\u2010apheresis improves coronary artery stenosis (CAS) as well as ischemic limbs seen in patients with peripheral arterial occlusive disease (PAOD), the underlying mechanisms remain still unknown. LDL\u2010apheresis might exert its favorable action through anti\u2010inflammatory effects. We studied whether or not serum or plasma levels of P\u2010selectin, high sensitivity C\u2010reactive protein (hsCRP), monocyte chemotractant protein\u20101 (MCP\u20101) or fibrinogen could be reduced in patients with PAOD before and after 10\u2003sessions of LDL\u2010apheresis. Sixteen patients (12 patients with hemodialysis, HD) with PAOD were enrolled in the present study. LDL\u2010apheresis was carried out 10 times (treated plasma of 3000\u2003mL) over 5\u2003weeks. Serum levels of P\u2010selectin were significantly reduced from 516\u2003\u00b1\u2003153 to 290\u2003\u00b1\u200352\u2003ng\/mL before and after 10\u2010sessions of LDL\u2010apheresis, respectively (<jats:italic>P<\/jats:italic>\u2003&lt;\u20030.05). Likewise, serum levels of hsCRP decreased from 9.118\u2003\u00b1\u20032.649 to 5.587\u2003\u00b1\u20032.445\u2003mg\/L (<jats:italic>P<\/jats:italic>\u2003&lt;\u20030.01); and plasma fibrinogen levels statistically decreased from 196\u2003\u00b1\u20039.82 to 149\u2003\u00b1\u20037.97\u2003mg\/dL (<jats:italic>P<\/jats:italic>\u2003&lt;\u20030.01), whereas serum levels of MCP\u20101 were not significantly changed. The favorable actions of LDL\u2010apheresis might include anti\u2010inflammatory effects, which could lead to an improvement of CAS and PAOD. Moreover, this intervention might be applicable for patients with atherosclerotic cardiovascular disorders, particularly in patients with HD.<\/jats:p>","DOI":"10.1111\/j.1744-9987.2006.00332.x","type":"journal-article","created":{"date-parts":[[2006,7,1]],"date-time":"2006-07-01T13:13:57Z","timestamp":1151759637000},"page":"219-223","source":"Crossref","is-referenced-by-count":45,"title":["LDL\u2010Apheresis Reduces P\u2010Selectin, CRP and Fibrinogen\u2014 Possible Important Implications for Improving 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