{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,20]],"date-time":"2026-06-20T15:10:20Z","timestamp":1781968220264,"version":"3.54.5"},"reference-count":10,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2006,6,30]],"date-time":"2006-06-30T00:00:00Z","timestamp":1151625600000},"content-version":"vor","delay-in-days":29,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Ther Apher Dial"],"published-print":{"date-parts":[[2006,6]]},"abstract":"<jats:p><jats:bold>Abstract:\u2002<\/jats:bold> We experienced a case manifesting progressive multifocal leukoencephalopathy (PML) in a hemodialytic patient with hepatitis C virus\u2010induced liver cirrhosis and human T\u2010cell lymphotropic virus type\u20101 (HTLV\u20101)\u2010associated uveitis. A 57\u2010year\u2010old male patient had received chronic hemodialysis therapy for 10\u2003years, during which he received multiple blood transfusions and HTLV\u20101\u2010associated uveitis developed. He complained of visual disturbance and disorientation. Brain CT scan showed diffuse and multifocal low density areas in occipital and temporal lobes, with gray matter relatively spared. MRI imaging showed high intensity lesions in the same areas. Cerebrospinal fluid culture was negative, but using nested PCR, rearranged regulatory region of JC virus DNA was detected. His consciousness level gradually deteriorated and complete paraplegia developed. Seven months after admission, he died of pneumonia. An autopsy confirmed the diagnosis of PML. Notably, mononuclear cell infiltration, gliosis and demyelinating lesions but no nuclear inclusion bodies were observed in the thoracic cord, which suggested HTLV\u20101\u2010associated myelopathy. Because JC virus is activated under immunocompromised conditions, precipitating factors in this case appear multifactorial; depressed immune system induced by chronic hemodialysis as well as blood\u2010borne hepatitis C virus\/HTLV\u20101 infection might contribute to the activation of dormant JC virus and the development of florid clinical manifestation of PML.<\/jats:p>","DOI":"10.1111\/j.1744-9987.2006.00371.x","type":"journal-article","created":{"date-parts":[[2006,7,1]],"date-time":"2006-07-01T13:13:57Z","timestamp":1151759637000},"page":"291-295","source":"Crossref","is-referenced-by-count":9,"title":["A Case Report of Progressive Multifocal Leukoencephalopathy in a Human T\u2010Cell Lymphotropic Virus Type 1\u2010Infected Hemodialytic Patient"],"prefix":"10.1111","volume":"10","author":[{"given":"Hiroto","family":"Matsuda","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Koichi","family":"Hayashi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mariko","family":"Meguro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takao","family":"Saruta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2006,6,30]]},"reference":[{"key":"e_1_2_5_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(71)91777-6"},{"key":"e_1_2_5_3_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00694906"},{"key":"e_1_2_5_4_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00308469"},{"key":"e_1_2_5_5_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.275.22.17016"},{"key":"e_1_2_5_6_2","doi-asserted-by":"publisher","DOI":"10.1007\/s007050050284"},{"key":"e_1_2_5_7_2","doi-asserted-by":"publisher","DOI":"10.2169\/internalmedicine.33.718"},{"key":"e_1_2_5_8_2","doi-asserted-by":"publisher","DOI":"10.2169\/internalmedicine.38.932"},{"key":"e_1_2_5_9_2","first-page":"1782","volume-title":"Oxford Textbook of Hepatology","author":"Mehta AB","year":"1999"},{"key":"e_1_2_5_10_2","first-page":"133","article-title":"Progressive multifocal leukoencephalopathy in elderly immunocompetent patients. Reports of 2 cases","volume":"29","author":"Bosch J","year":"1999","journal-title":"Rev Neurol"},{"key":"e_1_2_5_11_2","doi-asserted-by":"publisher","DOI":"10.1089\/08828240152716547"}],"container-title":["Therapeutic Apheresis and Dialysis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1744-9987.2006.00371.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1744-9987.2006.00371.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,10]],"date-time":"2023-10-10T21:37:35Z","timestamp":1696973855000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1744-9987.2006.00371.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,6]]},"references-count":10,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2006,6]]}},"alternative-id":["10.1111\/j.1744-9987.2006.00371.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1744-9987.2006.00371.x","archive":["Portico"],"relation":{},"ISSN":["1744-9979","1744-9987"],"issn-type":[{"value":"1744-9979","type":"print"},{"value":"1744-9987","type":"electronic"}],"subject":[],"published":{"date-parts":[[2006,6]]}}}