{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,27]],"date-time":"2026-05-27T14:20:01Z","timestamp":1779891601572,"version":"3.53.1"},"reference-count":19,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2006,11,10]],"date-time":"2006-11-10T00:00:00Z","timestamp":1163116800000},"content-version":"vor","delay-in-days":40,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Ther Apher Dial"],"published-print":{"date-parts":[[2006,10]]},"abstract":"<jats:p><jats:bold>Abstract:\u2002<\/jats:bold> Recently, direct hemoperfusion with a polymyxin B\u2010coated fiber column (DHP\u2010PMX) has been increasingly used for the treatment of sepsis, and an improvement in outcomes has been reported. However, the mechanism of the method is not known in detail. In the present study, we examined whether the performance of DHP\u2010PMX improved tissue oxygen metabolism in patients with sepsis. Twenty\u2010two patients with sepsis, satisfying the following criteria, were enrolled in the study: (i) signs of systemic inflammatory response syndrome caused by infection; and (ii) mean arterial blood pressure \u226560\u2003mm\u2003Hg (irrespective of the use of catecholamines). A thermodilution catheter was inserted prior to DHP\u2010PMX for appropriate intravenous infusion, and the DHP\u2010PMX was carried out twice within 24\u2003h (for 3\u2003h each time). Then, the gastric mucosal\u2010arterial PCO<jats:sub>2<\/jats:sub> difference (PCO<jats:sub>2<\/jats:sub> gap) was calculated as the gastric mucosal PCO<jats:sub>2<\/jats:sub> minus arterial PCO<jats:sub>2<\/jats:sub>. A PCO<jats:sub>2<\/jats:sub> gap \u22658\u2003mm\u2003Hg was used to define abnormal tissue oxygen metabolism. PCO<jats:sub>2<\/jats:sub> gap was measured before PMX\u2010DHP, as well as 24, 48, and 72\u2003h afterward. PCO<jats:sub>2<\/jats:sub> gap was 20\u2003\u00b1\u20034.9\u2003mm\u2003Hg before DHP\u2010PMX vs. 16\u2003\u00b1\u20032.7\u2003mm\u2003Hg (<jats:italic>P<\/jats:italic>\u2003= 0.189) at 24\u2003h, 12\u2003\u00b1\u20032.8\u2003mm\u2003Hg (<jats:italic>P<\/jats:italic>\u2003= 0.046) at 48\u2003h, and 11\u2003\u00b1\u20032.2\u2003mm\u2003Hg (<jats:italic>P<\/jats:italic>\u2003= 0.045) at 72\u2003h afterward, showing a significant decrease from 48\u2003h onward compared with before treatment. These findings suggest that DHP\u2010PMX improves tissue oxygen metabolism.<\/jats:p>","DOI":"10.1111\/j.1744-9987.2006.00407.x","type":"journal-article","created":{"date-parts":[[2006,11,10]],"date-time":"2006-11-10T09:18:44Z","timestamp":1163150324000},"page":"430-435","source":"Crossref","is-referenced-by-count":15,"title":["Hemoperfusion With an Immobilized Polymyxin B Fiber Column Improves Tissue Oxygen Metabolism"],"prefix":"10.1111","volume":"10","author":[{"given":"Hidehiko","family":"Kushi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takahiro","family":"Miki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Nakahara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazuhiko","family":"Okamoto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yayoi","family":"Kawahara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takeshi","family":"Saito","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katsuhisa","family":"Tanjoh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2006,11,10]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1378\/chest.101.6.1644"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1097\/00003246-199108000-00011"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/0140-6736(92)90002-K"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1378\/chest.113.4.1064"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1001\/archsurg.1985.01390340007001"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1097\/00003246-199109000-00009"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1526-0968.2003.00006.x"},{"key":"e_1_2_6_9_2","first-page":"60","article-title":"Tonometry: 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