{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,7]],"date-time":"2026-03-07T02:46:12Z","timestamp":1772851572715,"version":"3.50.1"},"reference-count":31,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2007,5,6]],"date-time":"2007-05-06T00:00:00Z","timestamp":1178409600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Ther Apher Dial"],"published-print":{"date-parts":[[2007,6]]},"abstract":"<jats:p><jats:bold>Abstract:\u2002<\/jats:bold> The purpose of this crossover comparison study is to elucidate the differences between the effects of a novel calcitriol analog, 22\u2010oxacalcitriol, and calcitriol on parathyroid hormone (PTH) and bone mineral metabolism in hemodialysis patients with secondary hyperparathyroidism (SHPT). Twenty\u2010three patients with moderate to severe SHPT were included in a random 2\u2003\u00d7\u20032 crossover trial with two vitamin\u2003D analogs (12\u2003weeks for each treatment). Two patients withdrew during the run\u2010in period for personal reasons. Serum electrolyte, bone metabolic marker, intact PTH (iPTH) and whole PTH (wPTH) levels were measured periodically. The primary endpoint measure was a decrease in serum iPTH level, and the secondary outcome measures included changes in serum calcium (Ca), phosphate (P), and metabolic bone marker levels. Both treatments decreased iPTH and wPTH levels by similar degrees. Serum Ca, P, and Ca\u2003\u00d7\u2003P product levels at the end of each treatment were comparable and the frequencies of hypercalcemia and hyperphosphatemia were also similar during each treatment period. 22\u2010Oxacalcitriol significantly decreased the levels of bone metabolic markers, namely, bone\u2010specific alkaline phosphate, intact osteocalcin, pyridinoline, and cross\u2010linked N\u2010telopeptide of type\u2003I collagen, after a 12\u2010week treatment. In contrast, calcitriol did not change any of the levels of bone metabolic markers. The present study showed that 22\u2010oxacalcitriol is equally effective for PTH suppression, and Ca and P metabolism. In addition, 22\u2010oxacalcitriol might have putative actions on bone remodeling independent of its PTH suppression. Further study is necessary to confirm the effects of 22\u2010oxacalcitriol on bone metabolism in SHPT.<\/jats:p>","DOI":"10.1111\/j.1744-9987.2007.00422.x","type":"journal-article","created":{"date-parts":[[2007,5,9]],"date-time":"2007-05-09T21:22:51Z","timestamp":1178745771000},"page":"202-209","source":"Crossref","is-referenced-by-count":6,"title":["Effects of 22\u2010Oxacalcitriol and Calcitriol on PTH Secretion and Bone Mineral Metabolism in a Crossover Trial in Hemodialysis Patients With Secondary 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