{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,18]],"date-time":"2026-03-18T11:19:47Z","timestamp":1773832787375,"version":"3.50.1"},"reference-count":25,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2007,3,22]],"date-time":"2007-03-22T00:00:00Z","timestamp":1174521600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Ther Apher Dial"],"published-print":{"date-parts":[[2007,4]]},"abstract":"<jats:p><jats:bold>Abstract:\u2002<\/jats:bold> Peritoneal dialysis (PD) solutions containing glucose are considered to cause peritoneal fibrosis. Plasminogen activator inhibitor\u20101 (PAI\u20101) and tissue\u2010type plasminogen activator (t\u2010PA) participate in fibrogenesis of various organs, and human peritoneal mesothelial cells (HPMC) can produce PAI\u20101 and t\u2010PA following glucose stimulation. Icodextrin has been widely used as an alternative osmotic agent. In this study, we investigated whether icodextrin\u2010based PD solution reduced the production of PAI\u20101 and t\u2010PA by HPMC. We also examined the involvement of extracellular signal\u2010regulated kinase\u20031\/2 (ERK1\/2). Glucose\u2010based PD solutions increased the production of PAI\u20101 and t\u2010PA by HPMC, whereas icodextrin\u2010based PD solution exerted lesser effects. Glucose\u2010based PD solutions activated ERK1\/2, and PD98059 inhibited the production of PAI\u20101 and t\u2010PA\u2014responses not observed with icodextrin\u2010based PD solution. In conclusion, glucose<jats:bold>\u2010<\/jats:bold>based PD solutions, unlike icodextrin\u2010based PD solution, induce overproduction of PAI\u20101 and t\u2010PA via the ERK1\/2 pathway.<\/jats:p>","DOI":"10.1111\/j.1744-9987.2007.00423.x","type":"journal-article","created":{"date-parts":[[2007,3,22]],"date-time":"2007-03-22T14:37:40Z","timestamp":1174574260000},"page":"94-100","source":"Crossref","is-referenced-by-count":16,"title":["Glucose\u2010Based PD Solution, But Not Icodextrin\u2010Based PD Solution, Induces Plasminogen Activator Inhibitor\u20101 and Tissue\u2010Type Plasminogen Activator in Human Peritoneal Mesothelial Cells via 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