{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,13]],"date-time":"2026-06-13T19:01:26Z","timestamp":1781377286666,"version":"3.54.1"},"reference-count":38,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2007,2,16]],"date-time":"2007-02-16T00:00:00Z","timestamp":1171584000000},"content-version":"vor","delay-in-days":15,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Ther Apher Dial"],"published-print":{"date-parts":[[2007,2]]},"abstract":"<jats:p><jats:bold>Abstract:\u2002<\/jats:bold> Orthostatic hypotension (OH) after hemodialysis (HD) is a serious complication, as it causes various neurological symptoms and even ischemic brain damage. The aim of the present study was to evaluate the effects of antihypotensive agents, midodrine hydrochloride (MID) and <jats:sc>l<\/jats:sc>\u2010threo\u20103,4\u2010dihydroxyphenylserine (L\u2010DOPS), on OH after HD. We measured systolic blood pressure (SBP) and cerebral blood flow velocity in the middle cerebral artery (MCVm, by transcranial Doppler sonography), in patients with OH during a 5\u2010min 60\u2010degree head\u2010up tilt test at both before and after 4\u2010week treatment with MID at 4\u2003mg\/day (<jats:italic>N<\/jats:italic>\u2003=\u20036) or L\u2010DOPS at 400\u2003mg\/day (<jats:italic>N<\/jats:italic>\u2003=\u20037). Both MID and L\u2010DOPS did not significantly protect against falls in systolic BP (SBP) after passive head\u2010up tilt. However, a significant improvement was achieved in MCVm\u2010decrement in the MID group at 3\u2003min and the L\u2010DOPS group at 0, 1 and 3\u2003min during head\u2010up tilt. Although MID and L\u2010DOPS did not prevent OH after HD in HD patients, both agents preserved cerebral blood flow during orthostasis in HD patients with OH.\u2003<\/jats:p>","DOI":"10.1111\/j.1744-9987.2007.00455.x","type":"journal-article","created":{"date-parts":[[2007,2,16]],"date-time":"2007-02-16T15:13:12Z","timestamp":1171638792000},"page":"49-55","source":"Crossref","is-referenced-by-count":17,"title":["Midodrine Hydrochloride and <scp>l<\/scp>\u2010threo\u20103,4\u2010dihydroxy\u2010Phenylserine Preserve Cerebral Blood Flow in Hemodialysis Patients With Orthostatic 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