{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,7]],"date-time":"2025-10-07T05:31:09Z","timestamp":1759815069666},"reference-count":43,"publisher":"Wiley","issue":"s1","license":[{"start":{"date-parts":[[2007,10,29]],"date-time":"2007-10-29T00:00:00Z","timestamp":1193616000000},"content-version":"vor","delay-in-days":28,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Ther Apher Dial"],"published-print":{"date-parts":[[2007,10]]},"abstract":"<jats:p><jats:bold>Abstract:\u2002<\/jats:bold> Fibroblast growth factor\u201023 (FGF\u201023) is a circulating factor regulating phosphate and vitamin\u2003D homeostasis. Phosphate intake and an administration of 1,25\u2010dihydroxyvitamin\u2003D<jats:sub>3<\/jats:sub> (1,25(OH)<jats:sub>2<\/jats:sub>D<jats:sub>3<\/jats:sub>) increase circulating FGF\u201023 levels, and elevated FGF\u201023 prevents hyperphosphatemia and vitamin\u2003D toxicity by hyperphosphaturia and suppression of circulating 1,25(OH)<jats:sub>2<\/jats:sub>D level, comprising a feedback loop to maintain phosphate and vitamin\u2003D homeostasis. Excess secretion of parathyroid hormone (PTH), another phosphaturic factor, elevates the serum calcium level in primary hyperparathyroidism. PTH also elevates circulating FGF\u201023 level, which cooperatively enhances the phosphaturia, resulting in hypophosphatemia.<\/jats:p><jats:p>The circulating FGF\u201023 level increases as renal function declines in chronic kidney disease (CKD), and it exhibits significant and positive correlations with serum phosphate, calcium, and PTH in CKD patients on maintenance hemodialysis, suggesting that these parameters regulate circulating FGF\u201023 level. Tight associations between circulating FGF\u201023 and calcium levels were observed both in patients with primary hyperparathyroidism and in CKD patients on maintenance hemodialysis, suggesting the role of serum calcium on FGF\u201023 regulatory mechanisms. FGF\u201023 may have a physiological role in preventing tissue damage such as ectopic calcifications, partly via suppressing the serum calcium\u2003\u00d7\u2003phosphate product by accelerating urinary phosphate excretion and suppressing vitamin\u2003D activation.<\/jats:p>","DOI":"10.1111\/j.1744-9987.2007.00519.x","type":"journal-article","created":{"date-parts":[[2007,10,29]],"date-time":"2007-10-29T22:08:57Z","timestamp":1193695737000},"source":"Crossref","is-referenced-by-count":8,"title":["Regulatory Mechanisms of Circulating Fibroblast Growth Factor\u200323 in Parathyroid 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