{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,6]],"date-time":"2025-11-06T19:52:18Z","timestamp":1762458738599},"reference-count":25,"publisher":"Wiley","issue":"s1","license":[{"start":{"date-parts":[[2008,10,23]],"date-time":"2008-10-23T00:00:00Z","timestamp":1224720000000},"content-version":"vor","delay-in-days":22,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Ther Apher Dial"],"published-print":{"date-parts":[[2008,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Serum parathyroid hormone (PTH) levels are effectively decreased by cinacalcet hydrochloride (HCl) in patients with secondary hyperparathyroidism. We assessed the impact of cinacalcet HCl on bone histology in these patients. Four hemodialysis patients with secondary hyperparathyroidism (intact PTH\u2003\u2265\u2003300\u2003pg\/mL) were treated with cinacalcet HCl with low\u2010doses of vitamin D sterols as well as calcium\u2010based phosphate binders for 52\u2003weeks. Patients 1, 2, 3 and 4 were aged 55, 65, 61 and 70\u2003years old, and the duration of hemodialysis in the patients was 84, 176, 125 and 216\u2003months, respectively. Serum intact PTH, serum bone metabolism markers and bone histomorphometric parameters were determined before and after 52\u2003weeks of the treatment. Serum intact PTH decreased from 1110, 880, 330 and 980\u2003pg\/mL to 233, 80, 88 and 116\u2003pg\/mL, respectively, in the four patients after 52\u2003weeks of treatment with cinacalcet HCl. Serum levels of bone metabolism markers and all of the histomorphometric resorption parameters decreased in these patients. In particular, fibrosis volume decreased to 0% in all of the patients. Static formation parameters, including osteoblast surface and osteoid\u2010related parameters, all decreased after the treatment, indicating an increase of mineralized bone volume during the treatment. Dynamic parameters except for activation frequency decreased after the treatment, indicating significant suppression of bone turnover. Cinacalcet HCl with low\u2010doses of vitamin D sterols suppressed serum PTH with no significant changes of serum calcium levels. In addition, long\u2010term administration of cinacalcet HCl improved hyperparathyroid bone diseases in patients with secondary hyperparathyroidism.<\/jats:p>","DOI":"10.1111\/j.1744-9987.2008.00630.x","type":"journal-article","created":{"date-parts":[[2009,6,22]],"date-time":"2009-06-22T05:53:43Z","timestamp":1245650023000},"source":"Crossref","is-referenced-by-count":18,"title":["Impact of Cinacalcet Hydrochloride on Bone Histology in Patients with Secondary 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