{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,13]],"date-time":"2026-11-13T10:26:45Z","timestamp":1794565605232,"version":"4.9.1"},"reference-count":24,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2008,12,30]],"date-time":"2008-12-30T00:00:00Z","timestamp":1230595200000},"content-version":"vor","delay-in-days":29,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Ther Apher Dial"],"published-print":{"date-parts":[[2008,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Heart valve calcification is an important predictor for all\u2010cause and cardiovascular mortality in hemodialysis patients. Recently, serum \u03b2<jats:sub>2<\/jats:sub>\u2010microglobulin has been associated with cardiovascular disease in the non\u2010hemodialysis population, but the relationship between serum \u03b2<jats:sub>2<\/jats:sub>\u2010microglobulin and valve calcification remains unknown. In this cross\u2010sectional study, we recorded the patients' clinical parameters, including serum \u03b2<jats:sub>2<\/jats:sub>\u2010microglobulin, and related these parameters to the number of calcified valves detected by echocardiography. The patients included 80 males and 35 females (age 67\u2003\u00b1\u200310\u2003years; duration on hemodialysis 96\u2003\u00b1\u200367\u2003months). Calcification of the aortic and mitral valves was observed in 89 (77.4%) and 59 patients (51.3%), respectively. Fifty\u2010one patients (44.3%) showed calcification of both valves. In univariate analysis, age (<jats:italic>r<\/jats:italic>\u2003=\u20030.301, <jats:italic>P<\/jats:italic>\u2003=\u20030.001), serum albumin (<jats:italic>r<\/jats:italic>\u2003=\u2003\u22120.219, <jats:italic>P<\/jats:italic>\u2003=\u20030.01), calcium (<jats:italic>r<\/jats:italic>\u2003=\u20030.205, <jats:italic>P<\/jats:italic>\u2003=\u20030.02), high sensitivity C\u2010reactive protein (<jats:italic>r<\/jats:italic>\u2003=\u20030.209, <jats:italic>P<\/jats:italic>\u2003=\u20030.02), and \u03b2<jats:sub>2<\/jats:sub>\u2010microglobulin (<jats:italic>r<\/jats:italic>\u2003=\u20030.206, <jats:italic>P<\/jats:italic>\u2003=\u20030.02) significantly correlated with the number of calcified valves. Stepwise multiple regression analysis showed that age (\u03b2\u2003=\u20030.389, <jats:italic>P<\/jats:italic>\u2003&lt;\u20030.001) and calcium (\u03b2\u2003=\u20030.223, <jats:italic>P<\/jats:italic>\u2003=\u20030.01) were independent determinants for valve calcification (<jats:italic>r<\/jats:italic><jats:sup>2<\/jats:sup>\u2003=\u20030.195). In addition, carotid intima media thickness was significantly higher in patients with valve calcification compared with those without valve calcification. Our results suggested the impacts of calcium metabolism and malnutrition\u2010inflammation complex syndrome on valve calcification. In addition, serum \u03b2<jats:sub>2<\/jats:sub>\u2010microglobulin may be another potential marker of cardiovascular complications in patients on hemodialysis.<\/jats:p>","DOI":"10.1111\/j.1744-9987.2008.00636.x","type":"journal-article","created":{"date-parts":[[2008,12,31]],"date-time":"2008-12-31T21:07:29Z","timestamp":1230757649000},"page":"464-468","source":"Crossref","is-referenced-by-count":23,"title":["Association of Heart Valve Calcification With Malnutrition\u2010Inflammation Complex Syndrome, \u03b2<sub>2<\/sub>\u2010Microglobulin, and Carotid Intima Media Thickness in Patients on Hemodialysis"],"prefix":"10.1111","volume":"12","author":[{"given":"Ryota","family":"Ikee","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenjiro","family":"Honda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Machiko","family":"Oka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kyoko","family":"Maesato","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tsutomu","family":"Mano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hidekazu","family":"Moriya","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takayasu","family":"Ohtake","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuzo","family":"Kobayashi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2008,12,30]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199907153410302"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000058168.26163.BC"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.105.552844"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1291\/hypres.28.505"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.106.683722"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1523-1755.2003.00920.x"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.165.3.327"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/13.8.2037"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0735-1097(01)01781-8"},{"key":"e_1_2_6_11_2","first-page":"335","article-title":"Role of ageing, chronic renal failure and dialysis in the calcification of mitral annulus","volume":"8","author":"Mazzaferro S","year":"1993","journal-title":"Nephrol Dial Transplant"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1523-1755.63.s85.27.x"},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2004.11.025"},{"key":"e_1_2_6_14_2","doi-asserted-by":"publisher","DOI":"10.1053\/j.ajkd.2003.11.009"},{"key":"e_1_2_6_15_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1797.2006.00696.x"},{"key":"e_1_2_6_16_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1523-1755.2002.00434.x"},{"key":"e_1_2_6_17_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1744-9987.2006.00440.x"},{"key":"e_1_2_6_18_2","doi-asserted-by":"crossref","first-page":"1927","DOI":"10.1681\/ASN.V1291927","article-title":"Association of inflammation and malnutrition with cardiac valve calcification in continuous ambulatory peritoneal dialysis patients","volume":"12","author":"Wang AY","year":"2001","journal-title":"J Am Soc Nephrol"},{"key":"e_1_2_6_19_2","doi-asserted-by":"publisher","DOI":"10.1053\/j.ajkd.2005.03.020"},{"key":"e_1_2_6_20_2","first-page":"205","article-title":"Determinants of coronary vascular calcification in patients with chronic kidney disease and end\u2010stage renal disease: a systematic review","volume":"17","author":"McCullough PA","year":"2004","journal-title":"J Nephrol"},{"key":"e_1_2_6_21_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.ki.5001820"},{"key":"e_1_2_6_22_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1797.2005.00475.x"},{"key":"e_1_2_6_23_2","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/14.9.2137"},{"key":"e_1_2_6_24_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1471-4906(03)00076-0"},{"key":"e_1_2_6_25_2","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2005020132"}],"container-title":["Therapeutic Apheresis and 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