{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,10,15]],"date-time":"2023-10-15T06:44:57Z","timestamp":1697352297408},"reference-count":25,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2009,7,17]],"date-time":"2009-07-17T00:00:00Z","timestamp":1247788800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Ther Apher Dial"],"published-print":{"date-parts":[[2010,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>15\u2010Deoxy\u2010\u0394<jats:sup>12,14<\/jats:sup>\u2010prostaglandin J<jats:sub>2<\/jats:sub> (15d\u2010PGJ<jats:sub>2<\/jats:sub>) is an endogenous peroxisome proliferator\u2010activated receptor \u03b3 (PPAR\u03b3) agonist that suppresses progressive matrix deposition; however, little is known about the effects of 15d\u2010PGJ<jats:sub>2<\/jats:sub> on human peritoneal mesothelial cells (HPMCs). We investigated the following: (i) the expression of PPAR\u03b3; (ii) the effect of 15d\u2010PGJ<jats:sub>2<\/jats:sub> on angiotensin II (Ang II)\u2010induced fibronectin (FN) expression and secretion; (iii) the effect of 15d\u2010PGJ<jats:sub>2<\/jats:sub> (with or without Ang II and with or without the specific PPAR\u03b3 antagonist GW9662) and pioglitazone, a synthetic PPAR\u03b3 agonist, on hepatocyte growth factor (HGF) expression and secretion; (iv) the effect of HGF on Ang II\u2010induced FN expression and secretion; (v) the expression of c\u2010Met (a specific HGF receptor) and its phospho\u2010signal; and (vi) the involvement of HGF in the effect produced by 15d\u2010PGJ<jats:sub>2<\/jats:sub> using selective c\u2010Met inhibitor PHA\u2010665752. The presence of PPAR\u03b3 was detected by western blot analysis. 15d\u2010PGJ<jats:sub>2<\/jats:sub> inhibited Ang II\u2010induced FN expression and increased HGF expression, even in the presence of Ang II. This effect of HGF expression was completely prevented by co\u2010treatment with GW9662. Additionally, upregulation of HGF secretion induced by 15d\u2010PGJ<jats:sub>2<\/jats:sub> and HGF production induced by pioglitazone was revealed. We demonstrated the presence of c\u2010Met, and presented evidence that HGF inhibits Ang II\u2010induced FN expression and activates phosphorylation of c\u2010Met, which is blocked by PHA\u2010665752; 15d\u2010PGJ<jats:sub>2<\/jats:sub> also activated c\u2010Met phosphorylation. Furthermore, PHA\u2010665752 attenuates the inhibitory effects of 15d\u2010PGJ<jats:sub>2<\/jats:sub> on FN secretion. These findings suggest that 15d\u2010PGJ<jats:sub>2<\/jats:sub> has a novel and potent antifibrotic effect in HPMC and this action is likely mediated by HGF.<\/jats:p>","DOI":"10.1111\/j.1744-9987.2009.00702.x","type":"journal-article","created":{"date-parts":[[2009,7,17]],"date-time":"2009-07-17T17:15:46Z","timestamp":1247850946000},"page":"43-51","source":"Crossref","is-referenced-by-count":8,"title":["15\u2010Deoxy\u2010\u0394<sup>12,14<\/sup>\u2010prostaglandin J<sub>2<\/sub> Inhibits Angiotensin II\u2010induced Fibronectin Expression via Hepatocyte Growth Factor Induction in Human Peritoneal Mesothelial Cells"],"prefix":"10.1111","volume":"14","author":[{"given":"Yukio","family":"Yokoyama","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takao","family":"Masaki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kei","family":"Kiribayashi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ayumu","family":"Nakashima","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Keiko","family":"Kokoroishi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takahiko","family":"Ogawa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nobuoki","family":"Kohno","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Noriaki","family":"Yorioka","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2010,2,12]]},"reference":[{"key":"e_1_2_7_2_2","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.V132470"},{"key":"e_1_2_7_3_2","doi-asserted-by":"publisher","DOI":"10.1101\/gad.8.10.1224"},{"key":"e_1_2_7_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(95)90193-0"},{"key":"e_1_2_7_5_2","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2005030257"},{"key":"e_1_2_7_6_2","doi-asserted-by":"publisher","DOI":"10.2337\/diabetes.53.1.200"},{"key":"e_1_2_7_7_2","doi-asserted-by":"publisher","DOI":"10.1161\/hc1002.105225"},{"key":"e_1_2_7_8_2","first-page":"907","article-title":"Influence 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