{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T19:27:55Z","timestamp":1791660475501,"version":"4.3.4"},"reference-count":39,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2009,10,30]],"date-time":"2009-10-30T00:00:00Z","timestamp":1256860800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Ther Apher Dial"],"published-print":{"date-parts":[[2010,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>We retrospectively analyzed 10\u2003906 lipid apheresis sessions (heparin\u2010induced lipoprotein precipitation, direct adsorption of lipoproteins, double filtration plasmapheresis, dextran sulfate adsorption, and immunoadsorption) in 38 patients who were consecutively treated in our department during the last 20\u2003years. The incidences of major cardiovascular events (MACE) (death, cerebrovascular accident, myocardial infarction, limb amputation, and renal vascular involvement) were taken separately as primary end\u2010points or as a combined end\u2010point. The time\u2010course of secondary end\u2010points (coronary and extracranial status of arteries, left ventricular function, occlusive artery disease, and calculated glomerular filtration rate [cGFR]) were also evaluated, as well as the extent of the reduction in plasma lipids and lipoproteins and the incidence of therapy associated side\u2010effects. MACE decreased from 7.02% events per patient per year at the start of lipid apheresis to 1.17% during lipid apheresis and the rate of myocardial revascularization decreased from 22.8% to 3.8% per patient per year. Classical (diabetes mellitus, arterial hypertension, and smoking history), as well as novel risk factors (cGFR\u2003&lt;\u200360\u2003mL\/min, statin withdrawal, mixed hyperlipoproteinemia, and elevated lipoprotein (a)) were associated with an elevated risk for MACE. All applied methods had comparable effects. All lipid apheresis methods proved to be safe and suitable for long\u2010term treatment. The present data demonstrate that treatment with lipid apheresis is very effective and leads to long\u2010term reduction in cardiovascular mortality and morbidity.\u2003<\/jats:p>","DOI":"10.1111\/j.1744-9987.2009.00747.x","type":"journal-article","created":{"date-parts":[[2009,10,30]],"date-time":"2009-10-30T07:22:49Z","timestamp":1256887369000},"page":"143-152","source":"Crossref","is-referenced-by-count":39,"title":["Retrospective Analysis of Long\u2010term Lipid Apheresis at a Single Center"],"prefix":"10.1111","volume":"14","author":[{"given":"Michael J","family":"Koziolek","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ulrich","family":"Hennig","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonia","family":"Zapf","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carsten","family":"Bramlage","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Clemens","family":"Grupp","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Victor W","family":"Armstrong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frank","family":"Strutz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gerhard A","family":"M\u00fcller","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2010,3,26]]},"reference":[{"key":"e_1_2_7_2_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000133317.49796.0E"},{"key":"e_1_2_7_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2005.04.064"},{"key":"e_1_2_7_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2004.03.046"},{"key":"e_1_2_7_5_2","first-page":"535","article-title":"State of the art treatment of the most difficult low density lipoprotein (LDL) cholesterol problems: LDL apheresis","volume":"100","author":"Whayne TF","year":"2002","journal-title":"J Ky Med Assoc"},{"key":"e_1_2_7_6_2","first-page":"2035","article-title":"Mitteilungen: zum Beschluss des Bundesausschusses der \u00c4rzte und Krankenkassen vom 24. 3. 2003 zu den therapeutischen Apheresen","volume":"30","author":"Kassen\u00e4rztliche Bundesvereinigung","year":"2003","journal-title":"Deutsch \u00c4rztebl"},{"key":"e_1_2_7_7_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1526-0968.2002.00426.x"},{"key":"e_1_2_7_8_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1526-0968.2003.00062.x"},{"key":"e_1_2_7_9_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1526-0968.2001.00359.x"},{"key":"e_1_2_7_10_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1526-0968.2003.00064.x"},{"key":"e_1_2_7_11_2","doi-asserted-by":"publisher","DOI":"10.1002\/jca.10035"},{"key":"e_1_2_7_12_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1526-0968.2001.00368.x"},{"key":"e_1_2_7_13_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1526-0968.2003.00074.x"},{"key":"e_1_2_7_14_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1526-0968.2002.00422.x"},{"key":"e_1_2_7_15_2","doi-asserted-by":"publisher","DOI":"10.1536\/ihj.46.833"},{"key":"e_1_2_7_16_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1526-0968.2003.00070.x"},{"key":"e_1_2_7_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0735-1097(02)01955-1"},{"key":"e_1_2_7_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9150(98)00328-1"},{"key":"e_1_2_7_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/0021-9150(92)90170-L"},{"key":"e_1_2_7_20_2","doi-asserted-by":"publisher","DOI":"10.1177\/039139880402700209"},{"key":"e_1_2_7_21_2","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfn127"},{"key":"e_1_2_7_22_2","doi-asserted-by":"publisher","DOI":"10.1136\/heart.89.suppl_3.iii2"},{"key":"e_1_2_7_23_2","doi-asserted-by":"publisher","DOI":"10.1097\/00041433-200310000-00012"},{"key":"e_1_2_7_24_2","doi-asserted-by":"publisher","DOI":"10.1093\/qjmed\/91.5.345"},{"key":"e_1_2_7_25_2","first-page":"25","article-title":"How to recognize POAD? 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