{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,14]],"date-time":"2026-11-14T10:23:39Z","timestamp":1794651819962,"version":"4.9.1"},"reference-count":17,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2010,3,24]],"date-time":"2010-03-24T00:00:00Z","timestamp":1269388800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Ther Apher Dial"],"published-print":{"date-parts":[[2010,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Patients with acquired cystic disease of the kidney (ACDK) were followed longitudinally over an average of 21.7\u2003\u00b1\u20035.4\u2003years to determine the natural history of the disease; that is, how big the kidneys become, when the kidney size reaches a plateau, and when the size regresses. Twenty\u2010seven male and 20 female patients with chronic glomerulonephritis treated at our hospital were investigated. CT scans were performed once a year and kidney volume was measured. Two different quadratic curves with a node of 5.2\u2003years for males and 2.5\u2003years for females after the start of hemodialysis were fitted to log\u2010transformed kidney volume to the duration of hemodialysis using a linear mixed model. The maximum kidney volume in male patients was obtained 21.1\u2003years after the start of hemodialysis using this model. Peak values of kidney volume were demonstrated in 19 of 26 cases during the observation period. The median peak value (interquartile range) of bilateral kidney volumes was 274 (165\u2013849)\u2003mL\/1.73\u2003m<jats:sup>2<\/jats:sup> occurring 19.1\u2003\u00b1\u20034.5\u2003years after the start of dialysis. In one male patient who had undergone nephrectomy due to renal cell carcinoma and in two of the remaining 26 male patients, the maximum kidney volume of 782 (residual kidney), 1151, and 1129\u2003mL regressed to 428, 616, and 847\u2003mL (reduction rate: 45.3, 46.5, and 25.0%) at 20.6, 25.4, and 23.1\u2003years after the start of hemodialysis, respectively. Kidney enlargement due to ACDK reached a plateau after 21.1\u2003years of hemodialysis in the male patients. Partial regression of severe ACDK may occur naturally after long\u2010term hemodialysis without renal transplantation.<\/jats:p>","DOI":"10.1111\/j.1744-9987.2010.00819.x","type":"journal-article","created":{"date-parts":[[2010,3,25]],"date-time":"2010-03-25T04:44:08Z","timestamp":1269492248000},"page":"409-416","source":"Crossref","is-referenced-by-count":19,"title":["Long\u2010Term Natural History of Acquired Cystic Disease of the Kidney"],"prefix":"10.1111","volume":"14","author":[{"given":"Isao","family":"Ishikawa","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Satoshi","family":"Hayama","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kyoko","family":"Morita","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tetsuya","family":"Nakazawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hitoshi","family":"Yokoyama","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryumon","family":"Honda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kyoko","family":"Satoh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tatsuyuki","family":"Kakuma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2010,7,23]]},"reference":[{"key":"e_1_2_6_2_2","volume-title":"Acquired Cystic Disease of the Kidney and Renal Cell Carcinoma\u2010Complication of Long\u2010Term Hemodialysis","author":"Ishikawa I","year":"2007"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1159\/000186434"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1136\/jcp.30.9.868"},{"key":"e_1_2_6_5_2","first-page":"1","article-title":"Development of acquired cystic disease and adenocarcinoma of the kidney in glomerulonephritic chronic hemodialysis patients","volume":"14","author":"Ishikawa I","year":"1980","journal-title":"Clin Nephrol"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1159\/000183401"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.5414\/CNP59153"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1038\/ki.2008.558"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1159\/000189555"},{"key":"e_1_2_6_10_2","volume-title":"Linear Mixed Models: A Practical Guide Using Statistical Software","author":"West BT","year":"2007"},{"key":"e_1_2_6_11_2","volume-title":"Spline Regression Models","author":"March LC","year":"2002"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0272-6386(12)80058-8"},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.2214\/ajr.156.3.1899744"},{"key":"e_1_2_6_14_2","doi-asserted-by":"publisher","DOI":"10.1038\/ki.1997.211"},{"key":"e_1_2_6_15_2","doi-asserted-by":"publisher","DOI":"10.1159\/000166738"},{"key":"e_1_2_6_16_2","doi-asserted-by":"publisher","DOI":"10.1053\/ajkd.2002.31407"},{"key":"e_1_2_6_17_2","doi-asserted-by":"publisher","DOI":"10.1159\/000187586"},{"key":"e_1_2_6_18_2","doi-asserted-by":"publisher","DOI":"10.1159\/000077590"}],"container-title":["Therapeutic Apheresis and Dialysis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1744-9987.2010.00819.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1744-9987.2010.00819.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,14]],"date-time":"2023-10-14T19:21:42Z","timestamp":1697311302000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1744-9987.2010.00819.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,7,23]]},"references-count":17,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2010,8]]}},"alternative-id":["10.1111\/j.1744-9987.2010.00819.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1744-9987.2010.00819.x","archive":["Portico"],"relation":{},"ISSN":["1744-9979","1744-9987"],"issn-type":[{"value":"1744-9979","type":"print"},{"value":"1744-9987","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010,7,23]]}}}