{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T03:04:24Z","timestamp":1782961464148,"version":"3.54.5"},"reference-count":18,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2010,11,30]],"date-time":"2010-11-30T00:00:00Z","timestamp":1291075200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Ther Apher Dial"],"published-print":{"date-parts":[[2010,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>There have been few long\u2010term prospective studies investigating the effect of cinacalcet on secondary hyperparathyroidism with or without nodular hyperplasia. We examined whether the effect of cinacalcet on secondary hyperparathyroidism differed between patients with or without nodular hyperplasia. Stable hemodialysis patients with secondary hyperparathyroidism resistant to conventional treatment received cinacalcet for 12\u2003months. Based on ultrasonography findings, patients were divided into group S (gland\u2003&lt;\u2003500\u2003mm<jats:sup>3<\/jats:sup> without nodular hyperplasia) and group L (gland\u2003\u2265\u2003500\u2003mm<jats:sup>3<\/jats:sup> with nodular hyperplasia). Serum levels of intact parathyroid hormone, bone\u2010specific alkaline phosphatase, osteocalcin, and cross\u2010linked N\u2010terminal telopeptide of type 1 collagen were measured. Thirty\u2010one patients completed the study. The changes of parameters from the baseline did not differ significantly between the two groups after 6\u2003months. However, the percentage reduction of each parameter was significantly smaller in group L compared with group S after 12\u2003months. Nodular hyperplasia is associated with resistance to cinacalcet therapy in patients on chronic dialysis with secondary hyperparathyroidism.<\/jats:p>","DOI":"10.1111\/j.1744-9987.2010.00843.x","type":"journal-article","created":{"date-parts":[[2010,8,4]],"date-time":"2010-08-04T14:58:14Z","timestamp":1280933894000},"page":"577-582","source":"Crossref","is-referenced-by-count":19,"title":["Association of Nodular Hyperplasia With Resistance to Cinacalcet Therapy for Secondary Hyperparathyroidism in Hemodialysis Patients"],"prefix":"10.1111","volume":"14","author":[{"given":"Takayuki","family":"Hirai","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ayumu","family":"Nakashima","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Norihisa","family":"Takasugi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Noriaki","family":"Yorioka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2010,11,30]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1098-2388(199703\/04)13:2<78::AID-SSU3>3.0.CO;2-Z"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfm177"},{"key":"e_1_2_6_4_2","doi-asserted-by":"crossref","first-page":"1141","DOI":"10.1681\/ASN.V1161141","article-title":"Cell biology of parathyroid gland hyperplasia in chronic renal failure","volume":"11","author":"Drueke TB","year":"2000","journal-title":"J Am Soc Nephrol"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1744-9987.2007.00489.x"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfg451"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1159\/000188261"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1098-2388(199703\/04)13:2<73::AID-SSU2>3.0.CO;2-Z"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1159\/000262301"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1093\/ndtplus\/sfn087"},{"key":"e_1_2_6_11_2","first-page":"1453","article-title":"Guideline for the management of secondary hyperparathyroidism in chronic dialysis patients","volume":"39","author":"Japanese Society for Dialysis Therapy","year":"2006","journal-title":"J Jpn Soc Dial Ther"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.4.5893.643"},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfn264"},{"key":"e_1_2_6_14_2","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfn654"},{"key":"e_1_2_6_15_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1523-1755.2005.67103.x"},{"key":"e_1_2_6_16_2","doi-asserted-by":"publisher","DOI":"10.1210\/jc.81.4.1598"},{"key":"e_1_2_6_17_2","doi-asserted-by":"publisher","DOI":"10.1038\/ki.1997.41"},{"key":"e_1_2_6_18_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1523-1755.2000.00370.x"},{"key":"e_1_2_6_19_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.ASN.0000141016.20133.33"}],"container-title":["Therapeutic Apheresis and Dialysis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1744-9987.2010.00843.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1744-9987.2010.00843.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,14]],"date-time":"2023-10-14T19:46:48Z","timestamp":1697312808000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1744-9987.2010.00843.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,11,30]]},"references-count":18,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2010,12]]}},"alternative-id":["10.1111\/j.1744-9987.2010.00843.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1744-9987.2010.00843.x","archive":["Portico"],"relation":{},"ISSN":["1744-9979","1744-9987"],"issn-type":[{"value":"1744-9979","type":"print"},{"value":"1744-9987","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010,11,30]]}}}