{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T01:39:35Z","timestamp":1789609175982,"version":"build-2803163510"},"reference-count":23,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2011,5,25]],"date-time":"2011-05-25T00:00:00Z","timestamp":1306281600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Ther Apher Dial"],"published-print":{"date-parts":[[2011,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Dialysis\u2010related amyloidosis (DRA) is one of the major complications often seen in long\u2010term dialysis patients, and is one of the factors that decreases quality of life. \u03b22\u2010microglobulin (\u03b22\u2010m) is considered to be a major pathogenic factor in dialysis\u2010related amyloidosis. The Lixelle adsorbent column, with various capacities, has been developed to adsorb \u03b22\u2010m from the circulating blood of patients with dialysis\u2010related amyloidosis. Using a minimum type of \u03b22\u2010m\u2010adsorbing column (Lixelle S\u201015), we evaluated its therapeutic efficacy and safety in dialysis patients. Seventeen hemodialysis patients with DRA were treated with the S\u201015 column for one year. Treatment was performed three times a week in this study. During the study period, pinch strength, visual analog scale for joint pain, and activities of daily living were evaluated every three months, and blood sampling was performed every six months. After one year's treatment with the S\u201015 column, the \u03b22\u2010m level decreased from 29.3\u2003\u00b1\u20039.6\u2003mg\/L to 24.7\u2003\u00b1\u20035.1\u2003mg\/L (<jats:italic>P<\/jats:italic>\u2003&lt;\u20030.05), and the high sensitive C\u2010reactive protein level decreased from 2996\u2003\u00b1\u20034380\u2003ng\/mL to 1292\u2003\u00b1\u20031774\u2003ng\/mL. After one year of S\u201015 column use, pinch strength increased from 5.9\u2003\u00b1\u20033.0\u2003pounds to 7.2\u2003\u00b1\u20033.2\u2003pounds (<jats:italic>P<\/jats:italic>\u2003&lt;\u20030.05), and the visual analog scale for joint pain and activities of daily living score also improved. Long\u2010term use of the Lixelle S\u201015 column is safe and effective for improvement of quality of life in chronic dialysis patients. Improvement of chronic inflammation may be one of the mechanisms through which the beneficial effects of the column is effected.<\/jats:p>","DOI":"10.1111\/j.1744-9987.2011.00937.x","type":"journal-article","created":{"date-parts":[[2011,5,25]],"date-time":"2011-05-25T14:25:01Z","timestamp":1306333501000},"page":"466-474","source":"Crossref","is-referenced-by-count":20,"title":["Long\u2010Term Efficacy and Safety of the Small\u2010Sized \u03b22\u2010Microglobulin Adsorption Column for Dialysis\u2010Related 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