{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T04:13:43Z","timestamp":1790914423315,"version":"4.1.0"},"reference-count":21,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2011,5,30]],"date-time":"2011-05-30T00:00:00Z","timestamp":1306713600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Ther Apher Dial"],"published-print":{"date-parts":[[2011,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Acute renal failure is a major complication of rhabdomyolysis. New membranes for hemodialysis have been developed with a high cut\u2010off pore size allowing efficient removal of myoglobin. We report on six patients treated by hemodiafiltration with a high cut\u2010off membrane (HCO\u2010HDF) for myoglobinuric acute renal failure. Rhabdomyolysis was caused by infection in two patients, by a statin in one patient and a non\u2010traumatic crush in another, and followed cardiovascular surgery in two others. Ten HCO\u2010HDF procedures were performed. A high cut\u2010off hemofilter was used, with citrate anticoagulation and postdilutional fluid substitution of 2\u20133\u2003L\/h, dialysate flow 500\u2003mL\/min, and blood flow within 250\u2013300\u2003mL\/min. Albumin losses were replaced by infusion of human albumin solution, and the mean myoglobin reduction ratio was 77% (range, 62\u201389%). An excellent clearance of 81\u2003mL\/min (range 42\u2013131\u2003mL\/min) was achieved. Nearly 5\u2003g of myoglobin was removed into the dialysate collected in one of the procedures. A high rebound in serum myoglobin, on average to 244% of the post\u2010procedure myoglobin level, was observed. The four patients alive at the time remained anuric for a week. Slow myoglobin elimination with a mean half\u2010time of 39\u2003h (range 19\u201359\u2003h) was observed in that period. Highly efficient myoglobin removal by high cut\u2010off membrane hemodiafiltration was demonstrated in our patients. Rapid redistribution from the extracellular fluid and sustained myoglobin release were suggested by the high rebound observed. Elimination of myoglobin within the body was shown in our study to occur slowly during the period of anuria.<\/jats:p>","DOI":"10.1111\/j.1744-9987.2011.00953.x","type":"journal-article","created":{"date-parts":[[2011,6,14]],"date-time":"2011-06-14T19:40:33Z","timestamp":1308080433000},"page":"287-291","source":"Crossref","is-referenced-by-count":32,"title":["High Cut\u2010Off Membrane Hemodiafiltration in Myoglobinuric Acute Renal Failure: A Case Series"],"prefix":"10.1111","volume":"15","author":[{"given":"Vladimir","family":"Premru","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Janko","family":"Kova\u010d","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jadranka","family":"Buturovi\u0107\u2010Ponikvar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rafael","family":"Ponikvar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2011,5,30]]},"reference":[{"key":"e_1_2_7_2_2","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.144.2.277"},{"key":"e_1_2_7_3_2","first-page":"1583","article-title":"Factors predictive of acute renal failure in rhabdomyolysis","volume":"148","author":"Ward MM","year":"1988","journal-title":"Arch Intern Med"},{"key":"e_1_2_7_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjsurg.2004.08.050"},{"key":"e_1_2_7_5_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-6576.2005.00577.x"},{"key":"e_1_2_7_6_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra0801327"},{"key":"e_1_2_7_7_2","doi-asserted-by":"publisher","DOI":"10.1186\/cc2978"},{"key":"e_1_2_7_8_2","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2005010070"},{"key":"e_1_2_7_9_2","doi-asserted-by":"publisher","DOI":"10.1159\/000063099"},{"key":"e_1_2_7_10_2","doi-asserted-by":"publisher","DOI":"10.1159\/000235961"},{"key":"e_1_2_7_11_2","doi-asserted-by":"publisher","DOI":"10.1053\/j.ajkd.2003.11.006"},{"key":"e_1_2_7_12_2","doi-asserted-by":"crossref","first-page":"2035","DOI":"10.1093\/ndt\/12.9.2035","article-title":"Significant myoglobin removal during continuous veno\u2010venous haemofiltration using F80 membrane","volume":"12","author":"Bastani B","year":"1997","journal-title":"Nephrol Dial Transplant"},{"key":"e_1_2_7_13_2","doi-asserted-by":"publisher","DOI":"10.1007\/s001340051031"},{"key":"e_1_2_7_14_2","first-page":"250A","article-title":"Myoglobin removal by high cut\u2010off hemodialysis: in\u2010vivo studies","volume":"18","author":"Hutchison CA","year":"2007","journal-title":"J Am Soc Nephrol"},{"key":"e_1_2_7_15_2","doi-asserted-by":"publisher","DOI":"10.1186\/cc3034"},{"key":"e_1_2_7_16_2","doi-asserted-by":"publisher","DOI":"10.1097\/CCM.0b013e3181feb7f0"},{"key":"e_1_2_7_17_2","doi-asserted-by":"publisher","DOI":"10.1186\/cc3055"},{"key":"e_1_2_7_18_2","doi-asserted-by":"crossref","first-page":"418","DOI":"10.1177\/039139880803100507","article-title":"Regional citrate anticoagulation for hemodialysis: calcium\u2010free vs. calcium containing dialysate\u2014a randomized trial","volume":"31","author":"Buturovic\u2010Ponikvar J","year":"2008","journal-title":"Int J Artif Organs"},{"key":"e_1_2_7_19_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF01690783"},{"key":"e_1_2_7_20_2","doi-asserted-by":"publisher","DOI":"10.1258\/0004563001899870"},{"key":"e_1_2_7_21_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF01707664"},{"key":"e_1_2_7_22_2","doi-asserted-by":"publisher","DOI":"10.1097\/00003246-200210000-00006"}],"container-title":["Therapeutic Apheresis and Dialysis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1744-9987.2011.00953.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1744-9987.2011.00953.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,14]],"date-time":"2023-10-14T10:29:01Z","timestamp":1697279341000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1744-9987.2011.00953.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,5,30]]},"references-count":21,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2011,6]]}},"alternative-id":["10.1111\/j.1744-9987.2011.00953.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1744-9987.2011.00953.x","archive":["Portico"],"relation":{},"ISSN":["1744-9979","1744-9987"],"issn-type":[{"value":"1744-9979","type":"print"},{"value":"1744-9987","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,5,30]]}}}