{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,16]],"date-time":"2025-10-16T13:56:20Z","timestamp":1760622980966},"reference-count":20,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2011,8,24]],"date-time":"2011-08-24T00:00:00Z","timestamp":1314144000000},"content-version":"vor","delay-in-days":23,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Ther Apher Dial"],"published-print":{"date-parts":[[2011,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Acute lung injury (ALI) in sepsis is characterized by an increase in microvascular permeability, resulting in pulmonary edema. Several studies have suggested that angiopoietin\u20101 and \u20102 play a contributory role in the pathogenesis of ALI. Polymyxin B\u2010immobilized fiber column hemoperfusion is effective for sepsis\u2010induced ALI. We investigated the angiopoietin levels before and after direct hemoperfusion with polymyxin B\u2010immobilized fiber column (PMX) therapy. Enzyme\u2010linked immunoassay was used to measure the serum angiopoietin\u20101 and \u20102 levels in 25 patients with septic shock treated with PMX. Eleven of the 25 patients were diagnosed with ALI. There was a significant positive correlation between the angiopoietin\u20101 level and the PaO<jats:sub>2<\/jats:sub>\/FiO<jats:sub>2<\/jats:sub> ratio, but there was a significant inverse correlation between the angiopoietin\u20102 level and the PaO<jats:sub>2<\/jats:sub>\/FiO<jats:sub>2<\/jats:sub> ratio. The mean angiopoietin\u20101 level before PMX therapy in the ALI group was significantly lower and the mean angiopoietin\u20102 level was significantly higher than in the non\u2010ALI group. The mean angiopoietin\u20101 level of the ALI patients in response to PMX therapy was increased during PMX therapy, but that of the non\u2010ALI patients with newly occurring ALI showed a decreased angiopoietin\u20101 level. On the other hand, the mean angiopoietin\u20102 level of the responders was decreased during PMX therapy, but that of patients with newly occurring ALI showed an increased angiopoietin\u20102 level. This result suggested that each angiopoietin\u20101 and \u20102 level may play a role in the pathogenesis of ALI and that PMX therapy ameliorates the angiopoietin balance in patients with ALI in sepsis.<\/jats:p>","DOI":"10.1111\/j.1744-9987.2011.00963.x","type":"journal-article","created":{"date-parts":[[2015,10,13]],"date-time":"2015-10-13T11:52:25Z","timestamp":1444737145000},"page":"349-354","source":"Crossref","is-referenced-by-count":11,"title":["Angiopoietin Balance in Septic Shock Patients With Acute Lung Injury: Effect of Direct Hemoperfusion With Polymyxin B\u2010Immobilized 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