{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,2]],"date-time":"2026-02-02T20:42:35Z","timestamp":1770064955561,"version":"3.49.0"},"reference-count":19,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2011,10,3]],"date-time":"2011-10-03T00:00:00Z","timestamp":1317600000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Ther Apher Dial"],"published-print":{"date-parts":[[2012,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Regional citrate anticoagulation (RCA) for continuous renal replacement therapy (CRRT) is associated with a longer filter life and fewer bleeding events. Complexity of the regimen is the major hurdle preventing widespread application. This study describes a simple predilution continuous venovenous hemofiltration (CVVH) protocol utilizing a commercially prepared replacement solution containing citrate (Prismocitrate\u200310\/2). Ten patients with acute renal failure were evaluated. The Prismaflex system was used for predilution CVVH, with Prismocitrate\u200310\/2 running at 2500\u2003mL\/h as the main predilution replacement. An 8.4% sodium bicarbonate solution was infused at 50\u2003mL\/h in the first 2\u2003h followed by 30\u2003mL\/h; 10% calcium gluconate was given to achieve an ionized calcium (iCa) level of 1\u20131.2\u2003mmol\/L. The circuit was run for 72\u2003h unless there was filter clotting, transportation was required, or the patient did not require further CRRT. Total treatment duration was 504.5\u2003h. The post\u2010dilution equivalent ultrafiltration rate was 32.9\u2003mL\/kg\/h (interquartile range [IQR] 31.6\u201338.2) and the median circuit life was 50.3\u2003h (IQR 25.5\u201372.0). None of the circuit was changed due to circuit clotting. The median systemic iCa was 0.98\u2003mmol\/L (IQR 0.91\u20131.08). The total calcium\u2010to\u2010iCa ratio was 2.33 (IQR 2.21\u20132.45). None of the patients developed hypernatremia (Na\u2003\u2265\u2003150\u2003mmol\/L) or citrate toxicity (total Ca\u2010to\u2010iCa ratio\u2003&gt;\u20032.5 plus increasing metabolic acidosis), and metabolic alkalosis (pH\u2003\u2265\u20037.5) occurred in one patient. This simple RCA CVVH protocol using commercially\u2010prepared solution could be a feasible, relatively safe, and effective alternative to the conventional regimen for patients with a body weight up to 80\u2003kg.<\/jats:p>","DOI":"10.1111\/j.1744-9987.2011.01001.x","type":"journal-article","created":{"date-parts":[[2011,10,4]],"date-time":"2011-10-04T03:39:55Z","timestamp":1317699595000},"page":"81-86","source":"Crossref","is-referenced-by-count":19,"title":["Regional Citrate Anticoagulation in Predilution Continuous Venovenous Hemofiltration Using Prismocitrate\u200310\/2 Solution"],"prefix":"10.1111","volume":"16","author":[{"given":"Hoi\u2010Ping","family":"Shum","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"King\u2010Chung","family":"Chan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wing\u2010Wa","family":"Yan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2011,10,3]]},"reference":[{"key":"e_1_2_7_2_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00134-007-0754-4"},{"key":"e_1_2_7_3_2","doi-asserted-by":"publisher","DOI":"10.1159\/000102137"},{"key":"e_1_2_7_4_2","doi-asserted-by":"publisher","DOI":"10.1159\/000187859"},{"key":"e_1_2_7_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0272-6386(12)80675-5"},{"key":"e_1_2_7_6_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1478-5153.2009.00339.x"},{"key":"e_1_2_7_7_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00134-002-1443-y"},{"key":"e_1_2_7_8_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00134-005-0044-y"},{"key":"e_1_2_7_9_2","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1177\/0310057X0703500411","article-title":"Continuous venovenous haemofiltration using a citrate buffered substitution fluid","volume":"35","author":"Schmitz M","year":"2007","journal-title":"Anaesth Intensive Care"},{"key":"e_1_2_7_10_2","doi-asserted-by":"publisher","DOI":"10.1186\/cc8747"},{"key":"e_1_2_7_11_2","unstructured":"GibneyN.Evaluation of a Simplified Protocol for Regional Citrate Anticoagulation in Continuous Venovenous Hemodiafiltration.2007[Accessed 18 Apr 2011.] Available from URL:http:\/\/clinicaltrials.gov\/ct2\/show\/study\/NCT00583765"},{"key":"e_1_2_7_12_2","doi-asserted-by":"publisher","DOI":"10.1097\/00003246-200104000-00010"},{"key":"e_1_2_7_13_2","first-page":"122","article-title":"Renal replacement therapy in critically ill patients","volume":"15","author":"Leung AK","year":"2009","journal-title":"Hong Kong Med J"},{"key":"e_1_2_7_14_2","doi-asserted-by":"publisher","DOI":"10.1038\/ki.1990.300"},{"key":"e_1_2_7_15_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00467-006-0049-y"},{"key":"e_1_2_7_16_2","doi-asserted-by":"publisher","DOI":"10.1159\/000046075"},{"key":"e_1_2_7_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(00)02430-2"},{"key":"e_1_2_7_18_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0802639"},{"key":"e_1_2_7_19_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0902413"},{"key":"e_1_2_7_20_2","doi-asserted-by":"publisher","DOI":"10.2215\/CJN.09111209"}],"container-title":["Therapeutic Apheresis and Dialysis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1744-9987.2011.01001.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1744-9987.2011.01001.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,14]],"date-time":"2023-10-14T15:51:58Z","timestamp":1697298718000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1744-9987.2011.01001.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,10,3]]},"references-count":19,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2012,2]]}},"alternative-id":["10.1111\/j.1744-9987.2011.01001.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1744-9987.2011.01001.x","archive":["Portico"],"relation":{},"ISSN":["1744-9979","1744-9987"],"issn-type":[{"value":"1744-9979","type":"print"},{"value":"1744-9987","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,10,3]]}}}