{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T22:09:06Z","timestamp":1791929346349,"version":"4.3.4"},"reference-count":33,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2012,2,2]],"date-time":"2012-02-02T00:00:00Z","timestamp":1328140800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Ther Apher Dial"],"published-print":{"date-parts":[[2012,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Atherosclerotic complications have a significant effect on mortality in patients undergoing hemodialysis (HD) therapy. However, anti\u2010atherosclerotic and cardioprotective effects of on\u2010line hemodiafiltration (HDF) remain to be elucidated. We prospectively compared the anti\u2010atherosclerotic and cardioprotective effects in two randomly divided groups, i.e. on\u2010line HDF group (<jats:italic>n<\/jats:italic>\u2003=\u200313) and conventional HD group (<jats:italic>n<\/jats:italic>\u2003=\u20039) for 1\u2003year. Surrogate markers were brachial\u2010ankle pulse wave velocity (baPWV), intima\u2010media thickness (IMT) of carotid artery as an atherosclerosis marker, and cardiac functional surrogate markers included left ventricular mass index (LVMI), ejection fraction (EF), and LV diastolic capacity represented as E\/A and deceleration time (DT). LVMI in on\u2010line HDF patients showed significant regression after 1\u2003year of treatment (131.9\u2003\u00b1\u200325.8 to 116.5\u2003\u00b1\u200324.7\u2003g\/m<jats:sup>2<\/jats:sup>, <jats:italic>P<\/jats:italic>\u2003=\u20030.03), while LVMI in HD patients did not show any significant change (148.0\u2003\u00b1\u200347.1 to 142.3\u2003\u00b1\u200335.5\u2003g\/m<jats:sup>2<\/jats:sup>). Levels of baPWV in HD patients showed a significant increase (11.4%) from basal levels, while on\u2010line HDF groups showed no significant increase. Furthermore, HD patients showed significant worsening of LV diastolic capacity (E\/A: from 0.87\u2003\u00b1\u20030.12 to 0.79\u2003\u00b1\u20030.08, <jats:italic>P<\/jats:italic>\u2003=\u20030.03), while it was not shown in on\u2010line HDF patients. Ejection fraction and IMT did not show any significant change in both groups. Serum albumin, C\u2010reactive protein, \u03b22 microglobulin, blood pressure, and anti\u2010hypertensive drug use did not change in both groups. On\u2010line HDF showed a significant improvement in LVMI and prevented a significant worsening of baPWV or LV diastolic capacity compared with patients on conventional HD therapy.<\/jats:p>","DOI":"10.1111\/j.1744-9987.2011.01042.x","type":"journal-article","created":{"date-parts":[[2012,2,2]],"date-time":"2012-02-02T12:41:15Z","timestamp":1328186475000},"page":"181-188","source":"Crossref","is-referenced-by-count":44,"title":["Cardiovascular Protective Effects of On\u2010Line Hemodiafiltration: Comparison With Conventional Hemodialysis"],"prefix":"10.1111","volume":"16","author":[{"given":"Takayasu","family":"Ohtake","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Machiko","family":"Oka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kunihiro","family":"Ishioka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenjiro","family":"Honda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasuhiro","family":"Mochida","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kyoko","family":"Maesato","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hidekazu","family":"Moriya","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sumi","family":"Hidaka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuzo","family":"Kobayashi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2012,2,2]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000143629.55725.D9"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0272-6386(00)70061-8"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1542-4758.2009.00423.x"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10157-003-0260-0"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1053\/j.ajkd.2009.01.261"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2004050409"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.105.607390"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM197403282901301"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1159\/000410781"},{"key":"e_1_2_6_11_2","first-page":"414","article-title":"Comparison between hemofiltration and hemodiafiltration in a long\u2010term prospective cross\u2010over study","volume":"17","author":"Altieri P","year":"2004","journal-title":"J Nephrol"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2010030280"},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.1159\/000090117"},{"key":"e_1_2_6_14_2","doi-asserted-by":"publisher","DOI":"10.1081\/JDI-100103491"},{"issue":"1","key":"e_1_2_6_15_2","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1093\/oxfordjournals.ndt.a027964","article-title":"On\u2010line hemodiafiltration. 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