{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T01:06:57Z","timestamp":1787015217226,"version":"build-2736575974"},"reference-count":35,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2012,8,13]],"date-time":"2012-08-13T00:00:00Z","timestamp":1344816000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Ther Apher Dial"],"published-print":{"date-parts":[[2012,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Fabry disease is an X\u2010linked lysosomal storage disorder due to deficient activity of alpha\u2010galactosidase A (\u03b1\u2010Gal A) leading to renal insufficiency in males. The aim of present study was to investigate the level of \u03b1\u2010Gal A activity and to determine the prevalence of Fabry disease in a Turkish male hemodialysis population. The activity of plasma \u03b1\u2010Gal A was measured in a group of 808 male hemodialysis patients using fluorimetric methods. Patients with low \u03b1\u2010Gal A activity were evaluated clinically and genetic testing was carried out. A correlation with creatinine, uric acid, urea, white blood cell (WBC), and high sensitivity (hs)CRP and \u03b1\u2010Gal A activity was also investigated. Plasma \u03b1\u2010Gal A activity among this male population undergoing hemodialysis was 7.88\u2003\u00b1\u20035.18\u2003\u00b5M\/hour\/L (0.40\u201355.72), significantly lower when compared to controls. No influence of creatinine, uric acid, WBC, or hsCRP on measured \u03b1\u2010Gal A activity was reported. Two new Fabry disease patients were identified. Both were previously diagnosed with diabetes mellitus type 2. These findings provide, for the first time, data regarding the prevalence of \u03b1\u2010Gal A deficiency (0.24%) in Turkish males receiving hemodialysis.<\/jats:p>","DOI":"10.1111\/j.1744-9987.2012.01092.x","type":"journal-article","created":{"date-parts":[[2012,8,13]],"date-time":"2012-08-13T08:03:19Z","timestamp":1344844999000},"page":"560-565","source":"Crossref","is-referenced-by-count":13,"title":["Alpha\u2010Galactosidase A Activity Levels in Turkish Male Hemodialysis Patients"],"prefix":"10.1111","volume":"16","author":[{"given":"Sema","family":"Kalkan U\u00e7ar","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eser","family":"Sozmen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Soner","family":"Duman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ali","family":"Ba\u015f\u00e7i","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mahmut","family":"\u00c7oker","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2012,8,13]]},"reference":[{"key":"e_1_2_7_2_2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-138-4-200302180-00014"},{"key":"e_1_2_7_3_2","doi-asserted-by":"publisher","DOI":"10.2215\/CJN.02490607"},{"key":"e_1_2_7_4_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1523-1755.2003.00160.x"},{"key":"e_1_2_7_5_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.ASN.0000124671.61963.1E"},{"key":"e_1_2_7_6_2","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfl528"},{"key":"e_1_2_7_7_2","doi-asserted-by":"publisher","DOI":"10.1007\/s101570050061"},{"key":"e_1_2_7_8_2","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfg194"},{"key":"e_1_2_7_9_2","first-page":"113","article-title":"Screening for Fabry disease in end\u2010stage nephropathies","volume":"25","author":"Spada M","year":"2002","journal-title":"J Inherit Metab Dis"},{"key":"e_1_2_7_10_2","unstructured":"WaltersBA PrichardM McCardleHet\u2003al.Prevalence of reduced plasma alpha\u2010galactosidase activity in a cohort of male patients on hemodialysis (HO) in the United States. Annual meeting of the American College of Medical Genetics; March 14\u201317 2002; New Orleans LA.2002."},{"key":"e_1_2_7_11_2","first-page":"c33","article-title":"Fabry disease in patients with end\u2010stage renal failure: the potential benefits of screening","volume":"101","author":"Bekri S","year":"2005","journal-title":"Nephron"},{"key":"e_1_2_7_12_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10157-005-0369-4"},{"key":"e_1_2_7_13_2","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1093\/clinchem\/20.3.383","article-title":"Variables in the laboratory diagnosis of Fabry's disease by measurement of methylumbelliferyl\u2010\u03b1\u2010galactosidase activity","volume":"20","author":"Brewster MA","year":"1974","journal-title":"Clin Chem"},{"key":"e_1_2_7_14_2","first-page":"157","article-title":"Fabry's disease: enzymatic diagnosis of hemizygotes and heterozygotes","volume":"81","author":"Desnick RJ","year":"1973","journal-title":"J Lab Clin Med"},{"key":"e_1_2_7_15_2","doi-asserted-by":"publisher","DOI":"10.1086\/504601"},{"key":"e_1_2_7_16_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1523-1755.2004.00883.x"},{"key":"e_1_2_7_17_2","doi-asserted-by":"publisher","DOI":"10.1086\/422366"},{"key":"e_1_2_7_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.semnephrol.2004.06.024"},{"key":"e_1_2_7_19_2","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfp105"},{"key":"e_1_2_7_20_2","doi-asserted-by":"publisher","DOI":"10.1093\/ndtplus\/sfn009"},{"key":"e_1_2_7_21_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1523-1755.2002.00097.x"},{"key":"e_1_2_7_22_2","doi-asserted-by":"publisher","DOI":"10.5414\/CNP64281"},{"key":"e_1_2_7_23_2","unstructured":"GasparP RodriguesD HerreraJet\u2003al.Which is the frequency of Fabry disease?2008439\u2010P Annual Symposium of the Society for the Study of Inborn Errors of Metabolism\u2014Lisboa Portugal 2008; 2\u20135 September 111."},{"key":"e_1_2_7_24_2","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/11.supp7.4"},{"key":"e_1_2_7_25_2","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfn370"},{"key":"e_1_2_7_26_2","doi-asserted-by":"publisher","DOI":"10.5414\/CNP75506"},{"key":"e_1_2_7_27_2","first-page":"11","article-title":"Frequency of Fabry disease in male and female haemodialysis pateints in Spain","volume":"1","author":"Gaspar P","year":"2010","journal-title":"BMC Med Genet"},{"key":"e_1_2_7_28_2","doi-asserted-by":"publisher","DOI":"10.1136\/jmg.2009.072116"},{"key":"e_1_2_7_29_2","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfm532"},{"key":"e_1_2_7_30_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10545-006-0484-8"},{"key":"e_1_2_7_31_2","doi-asserted-by":"publisher","DOI":"10.2215\/CJN.03130411"},{"key":"e_1_2_7_32_2","doi-asserted-by":"publisher","DOI":"10.2215\/CJN.05570809"},{"key":"e_1_2_7_33_2","doi-asserted-by":"publisher","DOI":"10.1203\/PDR.0b013e318183f132"},{"key":"e_1_2_7_34_2","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2006080816"},{"key":"e_1_2_7_35_2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-146-2-200701160-00148"},{"key":"e_1_2_7_36_2","first-page":"14","article-title":"Registry of the nephrology, dialysis and transplantation in Turkey registry","author":"Erek E","year":"2007","journal-title":"Turkish Society of Nephrology"}],"container-title":["Therapeutic Apheresis and Dialysis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1744-9987.2012.01092.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1744-9987.2012.01092.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,14]],"date-time":"2023-10-14T01:08:20Z","timestamp":1697245700000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1744-9987.2012.01092.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,8,13]]},"references-count":35,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2012,12]]}},"alternative-id":["10.1111\/j.1744-9987.2012.01092.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1744-9987.2012.01092.x","archive":["Portico"],"relation":{},"ISSN":["1744-9979","1744-9987"],"issn-type":[{"value":"1744-9979","type":"print"},{"value":"1744-9987","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,8,13]]}}}