{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,30]],"date-time":"2025-10-30T07:03:02Z","timestamp":1761807782789},"reference-count":19,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2012,11,20]],"date-time":"2012-11-20T00:00:00Z","timestamp":1353369600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Ther Apher Dial"],"published-print":{"date-parts":[[2013,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Our aim was to investigate the removal of myeloperoxidase\u2010anti\u2010neutrophil cytoplasmic antibody (MPO\u2010ANCA) from the circulation of patients with vasculitides by double\u2010filtration plasmapheresis (DFPP) using various primary separator and secondary separator combinations. Nineteen patients diagnosed with vasculitides positive for serum MPO\u2010ANCA were enrolled and received 56 sessions of DFPP. One patient received three sessions of DFPP using MPS07 (the primary filter)\/EC50W (the secondary filter), nine patients received 27 sessions of DFPP using MPS07\/EC20W, and the other nine patients received 26 sessions of DFPP using EC50W\/EC20W. The sieving coefficients (SC) of albumin, immunoglobulin (Ig)A, IgG and IgM were measured, as well as the reduction ratio in plasma protein concentrations and MPO\u2010ANCA titer after a single session of DFPP. The MPS07 filter was well permeable for all the above\u2010mentioned plasma proteins; the EC50W and EC20W filters were permeable for albumin and IgG, less for IgA and IgM. During DFPP using MPS07\/EC50W, the reduction ratio of IgG was much lower than IgM and IgA (30.5\u2003\u00b1\u20039.0% vs. 89.7\u2003\u00b1\u20035.4% and 61.7\u2003\u00b1\u200314.8%). During DFPP using MPS07\/EC20W, the decline in IgM, IgA, and IgG was 94.2\u2003\u00b1\u20033.1%, 96.2\u2003\u00b1\u20032.3%, and 64.7\u2003\u00b1\u200321.0%, respectively. During DFPP using EC50W\/EC20W, the decline in IgM, IgA, and IgG was 2.8\u2003\u00b1\u200312.9%, 90.9\u2003\u00b1\u20034.4%, and 43.5\u2003\u00b1\u200313.8%, respectively. The percentage reduction in MPO\u2010ANCA titer after a single session of DFPP using EC50W\/EC20W was 34.6\u2003\u00b1\u200314.3%. DFPP using EC50W\/EC20W filters may be more selective for the removal of pathogens such as IgG, with subsequently effective reduction of serum ANCA titer.<\/jats:p>","DOI":"10.1111\/j.1744-9987.2012.01107.x","type":"journal-article","created":{"date-parts":[[2012,11,20]],"date-time":"2012-11-20T14:50:40Z","timestamp":1353423040000},"page":"93-98","source":"Crossref","is-referenced-by-count":10,"title":["More Selective Removal of Myeloperoxidase\u2010Anti\u2010Neutrophil Cytoplasmic Antibody From the Circulation of Patients With Vasculitides Using a Novel Double\u2010Filtration Plasmapheresis Therapy"],"prefix":"10.1111","volume":"17","author":[{"given":"Dehua","family":"Gong","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daxi","family":"Ji","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bin","family":"Xu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhihong","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2012,11,20]]},"reference":[{"key":"e_1_2_6_2_2","first-page":"253","article-title":"Management of ANCA\u2010associated vasculitis: current trends and future prospects","volume":"6","author":"Hamour S","year":"2010","journal-title":"Ther Clin Risk Manag"},{"key":"e_1_2_6_3_2","first-page":"2089","article-title":"Prognosis of microscopic polyangiitis with renal involvement: report of 60 Chinese patients","volume":"118","author":"Hu WX","year":"2005","journal-title":"Chin Med J (Engl)"},{"key":"e_1_2_6_4_2","first-page":"60","article-title":"Treatment of ANCA\u2010associated systemic vasculitis","volume":"64","author":"Belmont HM","year":"2006","journal-title":"Bull NYU Hosp Jt Dis"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2007010090"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1526-0968.2002.00442.x"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1744-9987.2010.00808.x"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11926-007-0052-8"},{"key":"e_1_2_6_9_2","first-page":"312","article-title":"Staphylococcal protein A immunoadsorption for Goodpasture's syndrome in four Chinese patients","volume":"19","author":"Hu W","year":"2006","journal-title":"J Nephrol"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.rdc.2005.12.002"},{"key":"e_1_2_6_11_2","first-page":"677","article-title":"Waldenstrom's macroglobulinemia: recent advances in biology and therapy","volume":"7","author":"Neparidze N","year":"2009","journal-title":"Clin Adv Hematol Oncol"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1744-9987.2009.00747.x"},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1567-5688(09)71810-0"},{"key":"e_1_2_6_14_2","doi-asserted-by":"publisher","DOI":"10.1159\/000333209"},{"key":"e_1_2_6_15_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1872-034X.2010.00759.x"},{"key":"e_1_2_6_16_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1872-034X.2010.00708.x"},{"key":"e_1_2_6_17_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1872-034X.2007.00117.x"},{"key":"e_1_2_6_18_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.tp.0000296103.34735.b8"},{"key":"e_1_2_6_19_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1744-9987.2008.00642.x"},{"key":"e_1_2_6_20_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1744-9987.2008.00575.x"}],"container-title":["Therapeutic Apheresis and Dialysis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1744-9987.2012.01107.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1744-9987.2012.01107.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,14]],"date-time":"2023-10-14T03:42:10Z","timestamp":1697254930000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1744-9987.2012.01107.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,11,20]]},"references-count":19,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2013,2]]}},"alternative-id":["10.1111\/j.1744-9987.2012.01107.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1744-9987.2012.01107.x","archive":["Portico"],"relation":{},"ISSN":["1744-9979","1744-9987"],"issn-type":[{"value":"1744-9979","type":"print"},{"value":"1744-9987","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,11,20]]}}}