{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,3]],"date-time":"2026-01-03T06:27:35Z","timestamp":1767421655579},"reference-count":5,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2012,10,10]],"date-time":"2012-10-10T00:00:00Z","timestamp":1349827200000},"content-version":"vor","delay-in-days":9,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Ther Apher Dial"],"published-print":{"date-parts":[[2012,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>DF Thermo, a modified form of double\u2010filtration plasmapheresis (DFPP), has been used for the treatment of various indications such as arteriosclerosis obliterans (ASO). In case of ASO, fibrinogen is a substance to be removed by DFPP. On the other hand, plasmapheresis for chronic viral hepatitis C became an insurance covered treatment in Japan in April 2008. Since then DFPP has also become a treatment of chronic viral hepatitis C as an adjunctive therapy for the purpose of improving the effect of medication. Therefore, there has been a growing concern in recent years about patients' low fibrinogen levels due to DFPP treatment. With the aim of improving fibrinogen retention by DF Thermo, we examined by in vitro trial, the effects when recirculating the filtrate and elevating its temperature. The trial was conducted using bovine plasma, run through experimental circuits with the same configuration as the clinical setting of the One\u2010Way method and DF Thermo method. The DF Thermo circuit contained a thermostat, on which the temperature was set to 40\u00b0C. Two One\u2010Way method circuits were prepared with different temperature settings, i.e., 20\u00b0C and 40\u00b0C. With these three different conditions, variance of the fibrinogen retention under different temperatures and the implementation of recirculation were compared. Results show that the DF Thermo circuit tends to have enhanced the fibrinogen retention compared to the One\u2010Way method 20\u00b0C and 40\u00b0C. The explanation is likely as follows: viscosity of plasma reduces when warmed, which in turn helps maintain the permeability of membrane, and the recirculation of the plasma helps prevent membrane fouling, thus more fibrinogen is retained in the DF Thermo method.<\/jats:p>","DOI":"10.1111\/j.1744-9987.2012.01140.x","type":"journal-article","created":{"date-parts":[[2012,10,10]],"date-time":"2012-10-10T06:42:49Z","timestamp":1349851369000},"page":"472-477","source":"Crossref","is-referenced-by-count":3,"title":["Fibrinogen Salvage During DF Thermo Using Evaflux\u20105A Plasma Fractionators"],"prefix":"10.1111","volume":"16","author":[{"given":"Momoko","family":"Nakashima","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masahide","family":"Yasui","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Akira","family":"Ihara","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2012,10,10]]},"reference":[{"key":"e_1_2_7_2_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1525-1594.1985.tb04406.x"},{"key":"e_1_2_7_3_2","first-page":"1587","article-title":"Effect of temperature on filtration characteristics of eval secondary filter","volume":"15","author":"Sueoka A","year":"1986","journal-title":"Artif Organs"},{"key":"e_1_2_7_4_2","first-page":"264","article-title":"The performance and clinical effectiveness of new modified double filtration plasmapheresis (a warming recirculation method: DF thermo mode)","volume":"24","author":"Eguchi K","year":"2005","journal-title":"Jpn J Apheresis"},{"key":"e_1_2_7_5_2","first-page":"99","article-title":"Improvement of plasma fractionation property by heating or cooling techniques","volume":"25","author":"Konno Y","year":"2006","journal-title":"Jpn J Apheresis"},{"key":"e_1_2_7_6_2","first-page":"153","article-title":"Effect of temperature on the separation characteristics in a plasma fractionator","volume":"25","author":"Konno Y","year":"2006","journal-title":"Jpn J Apheresis"}],"container-title":["Therapeutic Apheresis and Dialysis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1744-9987.2012.01140.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1744-9987.2012.01140.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,14]],"date-time":"2023-10-14T01:22:14Z","timestamp":1697246534000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1744-9987.2012.01140.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,10]]},"references-count":5,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2012,10]]}},"alternative-id":["10.1111\/j.1744-9987.2012.01140.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1744-9987.2012.01140.x","archive":["Portico"],"relation":{},"ISSN":["1744-9979","1744-9987"],"issn-type":[{"value":"1744-9979","type":"print"},{"value":"1744-9987","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,10]]}}}