{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,31]],"date-time":"2026-08-31T11:07:33Z","timestamp":1788174453681,"version":"build-2803163510"},"reference-count":19,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2012,12,7]],"date-time":"2012-12-07T00:00:00Z","timestamp":1354838400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Ther Apher Dial"],"published-print":{"date-parts":[[2013,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    The optimal timing for renal replacement therapy initiation in septic acute kidney injury (AKI) remains controversial. This study investigates the impact of early versus late initiation of continuous renal replacement therapy (CRRT) on organ dysfunction among patients with septic shock and AKI. Patients were dichotomized into \u201cearly\u201d (simplified RIFLE Risk) or \u201clate\u201d (simplified RIFLE Injury or Failure) CRRT initiation. Patients with chronic kidney disease stage 5 or those on long\u2010term dialysis were excluded. Organ dysfunction was quantified by Sequential Organ Failure Assessment (SOFA) score. From January 2008 to June 2011, 120 patients fulfilled the inclusion criteria. Thirty\u2010one (26%) underwent \u201cearly\u201d while 89 (74%) had \u201clate\u201d CRRT. No significant difference was noted between groups on improvement of total SOFA\/non\u2010renal SOFA score or noradrenaline equivalent in the first 24 and 48\u2003h after CRRT initiation. Dialysis requirement and mortality (at 28 days, 3 months and 6 months) did not differ. In conclusion, improvement of non\u2010renal SOFA score 48\u2003h after CRRT correlated with SOFA score on CRRT initiation (\n                    <jats:italic>P<\/jats:italic>\n                    \u2003=\u20030.040) and APACHE IV risk of death (\n                    <jats:italic>P<\/jats:italic>\n                    \u2003=\u20030.000), but not estimated glomerular filtration rate on CRRT initiation (\n                    <jats:italic>P<\/jats:italic>\n                    \u2003=\u20030.377). Improvement of non\u2010renal SOFA score correlated with SOFA score on CRRT initiation and APACHE IV risk of death. However, this retrospective review cannot identify any significant clinical benefit of early CRRT initiation in patients presenting with septic shock and AKI.\n                  <\/jats:p>","DOI":"10.1111\/j.1744-9987.2012.01147.x","type":"journal-article","created":{"date-parts":[[2012,12,7]],"date-time":"2012-12-07T06:28:27Z","timestamp":1354861707000},"page":"305-310","source":"Crossref","is-referenced-by-count":28,"title":["Timing for Initiation of Continuous Renal Replacement Therapy in Patients With Septic Shock and Acute Kidney Injury"],"prefix":"10.1111","volume":"17","author":[{"given":"Hoi\u2010Ping","family":"Shum","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"King\u2010Chung","family":"Chan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ming\u2010Chit","family":"Kwan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alwin Wai\u2010Tak","family":"Yeung","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emily Wing\u2010Sze","family":"Cheung","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wing\u2010Wa","family":"Yan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2012,12,7]]},"reference":[{"key":"e_1_2_7_2_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.294.7.813"},{"key":"e_1_2_7_3_2","doi-asserted-by":"publisher","DOI":"10.1053\/ajkd.2002.32766"},{"key":"e_1_2_7_4_2","doi-asserted-by":"publisher","DOI":"10.1097\/00003246-200110000-00010"},{"key":"e_1_2_7_5_2","doi-asserted-by":"publisher","DOI":"10.2215\/CJN.03681106"},{"key":"e_1_2_7_6_2","doi-asserted-by":"publisher","DOI":"10.1186\/cc2872"},{"key":"e_1_2_7_7_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-6143.2004.00433.x"},{"key":"e_1_2_7_8_2","doi-asserted-by":"publisher","DOI":"10.1186\/cc10061"},{"key":"e_1_2_7_9_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.CCM.0000050454.01978.3B"},{"key":"e_1_2_7_10_2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-150-9-200905050-00006"},{"key":"e_1_2_7_11_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF01709751"},{"key":"e_1_2_7_12_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000542-200203000-00011"},{"key":"e_1_2_7_13_2","doi-asserted-by":"publisher","DOI":"10.2215\/CJN.01430406"},{"key":"e_1_2_7_14_2","doi-asserted-by":"publisher","DOI":"10.1186\/cc8147"},{"key":"e_1_2_7_15_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1542-4758.2009.00407.x"},{"key":"e_1_2_7_16_2","doi-asserted-by":"publisher","DOI":"10.1159\/000110560"},{"key":"e_1_2_7_17_2","doi-asserted-by":"publisher","DOI":"10.2215\/CJN.03830907"},{"key":"e_1_2_7_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcrc.2007.12.017"},{"key":"e_1_2_7_19_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1542-4758.2009.00347.x"},{"key":"e_1_2_7_20_2","doi-asserted-by":"publisher","DOI":"10.1510\/icvts.2008.181909"}],"container-title":["Therapeutic Apheresis and Dialysis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1744-9987.2012.01147.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1744-9987.2012.01147.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,14]],"date-time":"2023-10-14T08:30:50Z","timestamp":1697272250000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1744-9987.2012.01147.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,12,7]]},"references-count":19,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2013,6]]}},"alternative-id":["10.1111\/j.1744-9987.2012.01147.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1744-9987.2012.01147.x","archive":["Portico"],"relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.726162204.793514807","asserted-by":"object"}]},"ISSN":["1744-9979","1744-9987"],"issn-type":[{"value":"1744-9979","type":"print"},{"value":"1744-9987","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,12,7]]}}}