{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,11]],"date-time":"2025-11-11T12:46:36Z","timestamp":1762865196151},"reference-count":36,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2006,9,25]],"date-time":"2006-09-25T00:00:00Z","timestamp":1159142400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of the American Academy of Nurse Practitioners"],"published-print":{"date-parts":[[2006,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:bold>Purpose: <\/jats:bold> Conduct an integrative literature review to evaluate the safety and effectiveness of live\u2010virus vaccines, namely, the measles, mumps, rubella, and varicella vaccines, in children who are immune compromised by exogenous medication either posttransplant or while undergoing maintenance chemotherapy for leukemia.<\/jats:p><jats:p><jats:bold>Data sources: <\/jats:bold> Medline, MedlinePlus, EBSCO, PubMed, MD Consult, CINAHL, Clinical Pharmacology, ERIC, Biomedical Reference Collection\u2010Basic, Health Source\u2010Consumer Edition, Health Source\u2010Nursing\/Academic Edition, Ovid, CANCERLIT, and the Cochrane Library Online.<\/jats:p><jats:p><jats:bold>Conclusions: <\/jats:bold> Because measles infection has a low incidence rate in the United States, it may be advisable not to vaccinate children who are immunocompromised and risk side effects of the vaccine. In contrast to measles infection, varicella has a higher incidence rate and poses a more imminent threat to those who are immunocompromised. Children who are immunosuppressed can receive the varicella vaccination; however, they should have regular titers drawn to confirm adequate protection against the disease and should receive boosters as deemed appropriate.<\/jats:p><jats:p><jats:bold>Implications for practice: <\/jats:bold> The number of solid organ transplant recipients is steadily increasing with more than 600,000 solid organ transplantations worldwide since the first renal transplant in 1954. The steadily increasing numbers of pediatric patients surviving transplantation, coupled with increased life expectancy, accelerate the need for nurse practitioners to understand the management of these delicate patients following release from the transplant unit.<\/jats:p>","DOI":"10.1111\/j.1745-7599.2006.00163.x","type":"journal-article","created":{"date-parts":[[2006,9,25]],"date-time":"2006-09-25T09:22:03Z","timestamp":1159176123000},"page":"494-503","source":"Crossref","is-referenced-by-count":16,"title":["Safety of live\u2010virus vaccines for children with immune deficiency"],"prefix":"10.1111","volume":"18","author":[{"given":"Karlen E.","family":"Luthy","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mary E.","family":"Tiedeman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Renea L.","family":"Beckstrand","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Debra Ann","family":"Mills","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,9,25]]},"reference":[{"key":"e_1_2_7_2_1","first-page":"884","article-title":"Decline in annual incidence of varicella: Selected states, 1990\u20102001","volume":"52","author":"Ali A.","year":"2003","journal-title":"Morbidity and Mortality Weekly Report"},{"key":"e_1_2_7_3_1","doi-asserted-by":"crossref","first-page":"338","DOI":"10.1542\/peds.85.3.338","article-title":"Immunization of children with acute lymphoblastic leukemia with live attenuated varicella vaccine without complete suspension of chemotherapy","volume":"85","author":"Arbeter A.","year":"1990","journal-title":"Pediatrics"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.3949\/ccjm.68.4.337"},{"key":"e_1_2_7_5_1","doi-asserted-by":"crossref","first-page":"922","DOI":"10.1542\/peds.79.6.922","article-title":"Varicella\u2010like illness caused by live varicella vaccine in children with acute lymphocytic leukemia","volume":"79","author":"Brunell P.","year":"1987","journal-title":"Pediatrics"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/00006454-200202000-00015"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1086\/313823"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-104-3-377"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2141.2003.04356.x"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.3949\/ccjm.54.2.83"},{"key":"e_1_2_7_11_1","volume-title":"Clinical transplants 2000","author":"Cecka J.","year":"2000"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1097\/00007890-200011150-00023"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/s004670050313"},{"key":"e_1_2_7_14_1","first-page":"87","article-title":"Immunizations for pediatric transplant patients","volume":"43","author":"Gershon A","year":"1993","journal-title":"Kidney International"},{"key":"e_1_2_7_15_1","volume-title":"Immunofacts: Vaccines and immunologic drugs","author":"Grabenstein J","year":"2000"},{"issue":"3","key":"e_1_2_7_16_1","first-page":"11","article-title":"Immunization and organ transplant donors and recipients","volume":"20","author":"Grabenstein J","year":"2001","journal-title":"Pharmacy Practice Management Quarterly"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.qco.0000168384.31766.89"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM200003023420901"},{"key":"e_1_2_7_19_1","first-page":"364","article-title":"Vaccinations and solid\u2010organ transplantation: Review and recommendations","volume":"58","author":"Iglesias B.","year":"2003","journal-title":"Anales de Pediatria"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1097\/00007890-200208270-00020"},{"key":"e_1_2_7_21_1","first-page":"73","article-title":"A clinical trial of live attenuated varicella vaccine (Biken) in children with malignant diseases","volume":"27","author":"Konno T.","year":"1984","journal-title":"Biken Journal"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/174.Supplement_3.S320"},{"key":"e_1_2_7_23_1","first-page":"607","article-title":"Experience of varicella vaccination in acute lymphoplastic leukaemia","volume":"37","author":"Lou J.","year":"1996","journal-title":"Singapore Medical Journal"},{"key":"e_1_2_7_24_1","volume-title":"Principles and practice of infectious diseases","author":"Mandell G","year":"2000"},{"key":"e_1_2_7_25_1","unstructured":"Mayo Clinic. 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