{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,18]],"date-time":"2025-12-18T19:33:46Z","timestamp":1766086426656},"reference-count":19,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2007,5,23]],"date-time":"2007-05-23T00:00:00Z","timestamp":1179878400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of the American Academy of Nurse Practitioners"],"published-print":{"date-parts":[[2007,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:bold>Purpose: <\/jats:bold> To provide nurse practitioners with a basic understanding of the clinical presentation, diagnosis, diagnostic testing, pharmacological treatment, and prevalence of Wegener\u2019s granulomatosis (WG).<\/jats:p><jats:p><jats:bold>Data sources: <\/jats:bold> Published research and clinical articles, and a case report.<\/jats:p><jats:p><jats:bold>Conclusions: <\/jats:bold> WG is a systemic disease characterized by vasculitis, necrosis, and granulomas. The diagnosis of WG is difficult, particularly early in the disease process. In order to confirm the diagnosis, the patient should undergo specific tests such as antineutrophil cytoplasm antibodies, erythrocyte sedimentation rate, C\u2010reactive protein, and biopsy of the tissue involved.<\/jats:p><jats:p><jats:bold>Implications for practice: <\/jats:bold> The diagnosis of WG is often delayed because of the vague symptoms on presentation. Initial symptoms, such as chronic fatigue, upper respiratory infection, sinusitis, and otitis media are common and may not be alarming. Recognizing symptoms, ordering diagnostic tests, and providing appropriate pharmacological therapy is key to diagnosing and treating WG.<\/jats:p>","DOI":"10.1111\/j.1745-7599.2007.00231.x","type":"journal-article","created":{"date-parts":[[2007,5,25]],"date-time":"2007-05-25T04:01:29Z","timestamp":1180065689000},"page":"315-320","source":"Crossref","is-referenced-by-count":11,"title":["Wegener\u2019s granulomatosis: Symptoms, diagnosis, and treatment"],"prefix":"10.1111","volume":"19","author":[{"given":"Ivelisse","family":"Olivencia\u2010Simmons","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2007,5,23]]},"reference":[{"key":"e_1_2_9_2_1","volume-title":"Vasculitis. 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(1998).Types of vasculitis Wegener\u2019s granulomatosis. Retrieved April 17 2006 fromhttp:\/\/vasculitis.med.jhu.edu\/typesof\/wegeners.html"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1097\/00002281-200001000-00002"},{"key":"e_1_2_9_11_1","first-page":"519","article-title":"Pituitary involvement by Wegener\u2019s granulomatosis: A report of two cases","volume":"20","author":"Katzman G. 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