{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,9,19]],"date-time":"2024-09-19T15:11:52Z","timestamp":1726758712663},"reference-count":35,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2008,3,12]],"date-time":"2008-03-12T00:00:00Z","timestamp":1205280000000},"content-version":"vor","delay-in-days":11,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of the American Academy of Nurse Practitioners"],"published-print":{"date-parts":[[2008,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:bold>Purpose: <\/jats:bold> The purposes of this article are to provide a brief review of the complex biology of weight regulation and obesity, to explain some of the effects of diet and exercise on the biology of weight regulation and obesity, and to propose a coherent way to assess and treat people related to weight and obesity.<\/jats:p><jats:p><jats:bold>Data sources: <\/jats:bold> Scientific publications, clinical guidelines, and government sources.<\/jats:p><jats:p><jats:bold>Conclusions: <\/jats:bold> Obesity is a complex problem requiring an understanding of how interventions interact with the biology of weight regulation in people who are obese. Promoting health in obese people requires a focus on improving insulin sensitivity.<\/jats:p><jats:p><jats:bold>Implications for practice: <\/jats:bold> Helping individuals maintain normal weight throughout life is important in order to keep the long\u2010 and short\u2010term weight signals in balance and reflective of true energy requirements. Exercise is associated with loss of total and abdominal adipose tissue and improved insulin sensitivity. Diets inducing gradual weight loss are less likely to stimulate appetite. Diets should include antioxidants to neutralize the increase in free radical production associated with obesity and exercise. Other interventions in the treatment of obesity may include treating sleep deficits and the dysregulated endocannabinoid system.<\/jats:p>","DOI":"10.1111\/j.1745-7599.2007.00299.x","type":"journal-article","created":{"date-parts":[[2008,3,12]],"date-time":"2008-03-12T20:17:59Z","timestamp":1205353079000},"page":"128-135","source":"Crossref","is-referenced-by-count":6,"title":["Implications of the biology of weight regulation and obesity on the treatment of obesity"],"prefix":"10.1111","volume":"20","author":[{"given":"Ann","family":"Bellar","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Patricia A.","family":"Jarosz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David","family":"Bellar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2008,3,12]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2004-2438"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nut.2006.03.008"},{"key":"e_1_2_6_4_1","first-page":"2875","article-title":"Metabolic syndrome: Time for action","volume":"69","author":"Deen D","year":"2004","journal-title":"American Family Physician"},{"key":"e_1_2_6_5_1","unstructured":"Di Marzo V. Howlett A. C. Mackie K. &Reggio P. H. (Eds.). (2007).Endocannabinoid system overview. Endocannabinoid System Network. Retrieved March 3 2007 from http:\/\/www.endocannabinoid.net\/PrintArticle.aspx?id=39"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1136\/bjsm.35.1.3"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.2337\/diabetes.54.10.2838"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1079856"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI21625"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.299.5608.849"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.0300-0664.2001.01456.x"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cll.2004.01.007"},{"key":"e_1_2_6_13_1","volume-title":"Lifetime fitness","author":"Hoeger W. K.","year":"2006"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1753-4887.2006.tb00235.x"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pbb.2007.02.017"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pbb.2006.02.004"},{"key":"e_1_2_6_17_1","volume-title":"ACSM\u2019s resource manual for guidelines for exercise testing and prescription","author":"Kaminsky L. A","year":"2006"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.ijo.0803326"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00053.2005"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.299.5608.846"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2005-2679"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1038\/436337a"},{"key":"e_1_2_6_23_1","volume-title":"Clinical guidelines on the identification, evaluation, and treatment of overweight and obesity in adults","author":"National Institutes of Health","year":"1998"},{"key":"e_1_2_6_24_1","volume-title":"The practical guide identification, evaluation, and treatment of overweight and obesity in adults","author":"National Institutes of Health","year":"2000"},{"key":"e_1_2_6_25_1","volume-title":"Exercise testing and prescription: A health\u2010related approach","author":"Nieman D. C","year":"2007"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.01336.2005"},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.1301\/002966402320634797"},{"key":"e_1_2_6_28_1","volume-title":"Pathophysiology: Concepts of altered health states","author":"Porth C. M","year":"2002"},{"key":"e_1_2_6_29_1","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00124.2005"},{"key":"e_1_2_6_30_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2004-1003"},{"key":"e_1_2_6_31_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pmed.0010062"},{"key":"e_1_2_6_32_1","doi-asserted-by":"publisher","DOI":"10.1038\/oby.2006.261"},{"key":"e_1_2_6_33_1","unstructured":"Weight Control Information Network(May 2007).Statistics related to overweight and obesity NIDDK. Retrieved August 30 2007 fromhttp:\/\/win.niddk.nih.gov\/statistics\/index.htm#preval"},{"key":"e_1_2_6_34_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.nutr.21.1.323"},{"key":"e_1_2_6_35_1","doi-asserted-by":"publisher","DOI":"10.1301\/00296640260093823"},{"key":"e_1_2_6_36_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature03711"}],"container-title":["Journal of the American Academy of Nurse Practitioners"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1745-7599.2007.00299.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1745-7599.2007.00299.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,11]],"date-time":"2023-10-11T02:27:43Z","timestamp":1696991263000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1745-7599.2007.00299.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,3]]},"references-count":35,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2008,3]]}},"alternative-id":["10.1111\/j.1745-7599.2007.00299.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1745-7599.2007.00299.x","archive":["Portico"],"relation":{},"ISSN":["1041-2972","1745-7599"],"issn-type":[{"value":"1041-2972","type":"print"},{"value":"1745-7599","type":"electronic"}],"subject":[],"published":{"date-parts":[[2008,3]]}}}