{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,10,31]],"date-time":"2023-10-31T06:49:19Z","timestamp":1698734959730},"reference-count":32,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2012,5,3]],"date-time":"2012-05-03T00:00:00Z","timestamp":1336003200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of the American Academy of Nurse Practitioners"],"published-print":{"date-parts":[[2012,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:bold>Purpose:<\/jats:bold> To provide primary care providers with a general overview of the genetic disorder tuberous sclerosis complex (TSC). By understanding the disease mechanism for this genetic condition, providers can effectively care for TSC patients and properly educate families who are affected by TSC. The article also describes the multi\u2010system clinical presentation of the disease to assist primary care providers with an early diagnosis.<\/jats:p><jats:p><jats:bold>Data Resources:<\/jats:bold> Research articles and evidence\u2010based guidelines found through MEDLINE and the World Wide Web.<\/jats:p><jats:p><jats:bold>Conclusions:<\/jats:bold> Using various diagnostic tools and treatment options, providers can offer the multidisciplinary approach needed to manage this disease appropriately. New treatment options, such as rapamycin, may be the future drug of choice in treating TSC.<\/jats:p><jats:p><jats:bold>Implications for practice:<\/jats:bold> By following evidence\u2010based clinical practice guidelines, providers can hope to reduce TSC\u2010related morbidity and mortality.<\/jats:p>","DOI":"10.1111\/j.1745-7599.2012.00734.x","type":"journal-article","created":{"date-parts":[[2012,5,3]],"date-time":"2012-05-03T05:50:01Z","timestamp":1336024201000},"page":"391-399","source":"Crossref","is-referenced-by-count":2,"title":["Primary care management of tuberous sclerosis complex in children"],"prefix":"10.1111","volume":"24","author":[{"given":"Deepa","family":"Manohara","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2012,5,3]]},"reference":[{"key":"e_1_2_8_2_1","volume-title":"Collins Webster's dictionary","author":"Abate F.","year":"2005"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00247-008-0832-y"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa063564"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrdd.20024"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.juro.2007.07.058"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1177\/08830738060210011201"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00381-006-0130-7"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejpn.2006.03.001"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra055323"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.wco.0000218225.50807.12"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(08)61279-9"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1177\/0883073807309250"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00787-006-0570-3"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11689-009-9014-y"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.20784"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1528-1167.2007.01035.x"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2007-3762"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1177\/0883073807309788"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2007-2361"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1528-1167.2005.00266.x"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.2165\/00148581-200810050-00004"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pedhc.2006.05.004"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.3928\/00904481-20090201-08"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yebeh.2007.07.010"},{"issue":"5","key":"e_1_2_8_26_1","doi-asserted-by":"crossref","first-page":"1163","DOI":"10.1542\/peds.2007-2362","article-title":"Management of children with autism spectrum disorders","volume":"120","author":"Myers S. 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