{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,16]],"date-time":"2026-05-16T08:01:48Z","timestamp":1778918508991,"version":"3.51.4"},"reference-count":27,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2011,3,17]],"date-time":"2011-03-17T00:00:00Z","timestamp":1300320000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Chem Biol Drug Des"],"published-print":{"date-parts":[[2011,6]]},"abstract":"<jats:p>With the aim of identifying novel lead compounds active against emergent human infectious diseases, a series of 2,3\u2010dihydro\u20104H\u2010pyridinone derivatives has been prepared and evaluated for antiviral activity. Compounds were evaluated <jats:italic>in vitro<\/jats:italic> in cell\u2010based assays for cytotoxicity and against a wide spectrum of viruses. In the antiviral screening, several compounds showed to be fairly active against viruses belonging to the Flaviviridae family. The <jats:italic>Pestiviruses<\/jats:italic> (bovine viral diarrhoea virus) were inhibited by <jats:bold>4a<\/jats:bold><jats:italic>cis<\/jats:italic> (CC<jats:sub>50<\/jats:sub>\u2003&gt;\u2003100\u2003\u03bc<jats:sc>m<\/jats:sc>; EC<jats:sub>50<\/jats:sub> = 14\u2003\u03bc<jats:sc>m<\/jats:sc>), compounds <jats:bold>4c<\/jats:bold><jats:italic>cis<\/jats:italic> and <jats:bold>6a<\/jats:bold> showed a significant activity against <jats:italic>Flaviviruses<\/jats:italic> (Yellow Fever Virus) (CC<jats:sub>50<\/jats:sub>\u2003&gt;\u2003100\u2003\u03bc<jats:sc>m<\/jats:sc>; EC<jats:sub>50<\/jats:sub>\u2003=\u200318\u2003\u03bc<jats:sc>m<\/jats:sc>, CC<jats:sub>50<\/jats:sub>\u2003&gt;\u2003100\u2003\u03bc<jats:sc>m<\/jats:sc>; EC<jats:sub>50<\/jats:sub>\u2003=\u200310\u2003\u03bc<jats:sc>m<\/jats:sc>). Among these, compound <jats:bold>6a<\/jats:bold> displayed great inhibitory activity against <jats:italic>Hepaciviruses<\/jats:italic> (hepatitis C virus) in replicon assay [CC<jats:sub>50<\/jats:sub> &gt; 100\u2003\u03bc<jats:sc>m<\/jats:sc>; EC<jats:sub>50<\/jats:sub>(1b)\u2003=\u20034\u2003\u03bc<jats:sc>m<\/jats:sc>]. <jats:italic>In vitro<\/jats:italic> inhibitory activity against the HCV RNA\u2010dependent RNA polymerase (NS5B) of title compounds is discussed. The antiviral screening of viral strains indicated that compound <jats:bold>6a<\/jats:bold> can be selected as promising tool in novel anti\u2010flaviviruses development.<\/jats:p>","DOI":"10.1111\/j.1747-0285.2011.01102.x","type":"journal-article","created":{"date-parts":[[2011,3,17]],"date-time":"2011-03-17T12:51:34Z","timestamp":1300366294000},"page":"441-449","source":"Crossref","is-referenced-by-count":11,"title":["2,3\u2010Dihydro\u20101,2\u2010Diphenyl\u2010substituted 4H\u2010Pyridinone Derivatives as New Anti Flaviviridae Inhibitors"],"prefix":"10.1111","volume":"77","author":[{"given":"Antonella","family":"Peduto","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antonio","family":"Massa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antonia","family":"Di Mola","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paolo","family":"de Caprariis","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paolo","family":"La Colla","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roberta","family":"Loddo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sergio","family":"Altamura","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giovanni","family":"Maga","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rosanna","family":"Filosa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2011,3,17]]},"reference":[{"key":"e_1_2_4_2_2","doi-asserted-by":"publisher","DOI":"10.1517\/14656560802694481"},{"key":"e_1_2_4_3_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrd937"},{"key":"e_1_2_4_4_2","first-page":"991","volume-title":"Fields\u2019 Virology","author":"Lidenbach B.D.","year":"2001"},{"key":"e_1_2_4_5_2","doi-asserted-by":"publisher","DOI":"10.1177\/104063879801000106"},{"key":"e_1_2_4_6_2","first-page":"371","article-title":"Bovine viral diarrhea virus: biotypes and disease","volume":"36","author":"Deregt D.","year":"1995","journal-title":"Can Vet J"},{"key":"e_1_2_4_7_2","doi-asserted-by":"publisher","DOI":"10.1006\/viro.1994.1483"},{"key":"e_1_2_4_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0166-3542(03)00174-8"},{"key":"e_1_2_4_9_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.49.4.1346-1353.2005"},{"key":"e_1_2_4_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0166-3542(01)00164-4"},{"key":"e_1_2_4_11_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1114016"},{"key":"e_1_2_4_12_2","doi-asserted-by":"publisher","DOI":"10.1186\/1477-7819-3-27"},{"key":"e_1_2_4_13_2","doi-asserted-by":"publisher","DOI":"10.1038\/nm1268"},{"key":"e_1_2_4_14_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrd942"},{"key":"e_1_2_4_15_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0503596102"},{"key":"e_1_2_4_16_2","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2007.03.116"},{"key":"e_1_2_4_17_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMct061675"},{"key":"e_1_2_4_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/0166-0934(88)90134-6"},{"key":"e_1_2_4_19_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.285.5424.110"},{"key":"e_1_2_4_20_2","doi-asserted-by":"publisher","DOI":"10.3851\/IMP1286"},{"key":"e_1_2_4_21_2","doi-asserted-by":"publisher","DOI":"10.1055\/s-0028-1087677"},{"key":"e_1_2_4_22_2","doi-asserted-by":"publisher","DOI":"10.1002\/ejoc.200800697"},{"key":"e_1_2_4_23_2","doi-asserted-by":"publisher","DOI":"10.1021\/jo00302a036"},{"key":"e_1_2_4_24_2","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1002\/j.1460-2075.1996.tb00329.x","article-title":"Identification and properties of the RNA\u2010dependent RNA polymerase of hepatitis C virus","volume":"15","author":"Beherens S.E.","year":"1996","journal-title":"EMBO J"},{"key":"e_1_2_4_25_2","doi-asserted-by":"publisher","DOI":"10.2174\/1385272043485963"},{"key":"e_1_2_4_26_2","doi-asserted-by":"publisher","DOI":"10.2174\/1568005033481114"},{"key":"e_1_2_4_27_2","first-page":"225","article-title":"Hepatitis C virus RNA\u2010dependent RNA polymerase (NS5B polymerase)","volume":"242","author":"Hagedorn C.H.","year":"2000","journal-title":"Curr Top Microbiol Immunol"},{"key":"e_1_2_4_28_2","first-page":"441","article-title":"HCV NS5B polymerase inhibitors","volume":"13","author":"Watkins W.J.","year":"2010","journal-title":"Curr Opin Drug Discov Devel"}],"container-title":["Chemical Biology &amp; 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