{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,31]],"date-time":"2025-12-31T06:35:30Z","timestamp":1767162930207,"version":"build-2238731810"},"reference-count":19,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2011,3,25]],"date-time":"2011-03-25T00:00:00Z","timestamp":1301011200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Chem Biol Drug Des"],"published-print":{"date-parts":[[2011,5]]},"abstract":"<jats:p>\n                    Diethlenetriamine\u2010\n                    <jats:italic>N<\/jats:italic>\n                    ,\n                    <jats:italic>N<\/jats:italic>\n                    ,\n                    <jats:italic>N\u2032N\u2032\u2032N\u2032\u2032<\/jats:italic>\n                    \u2010pentaacetic acid (DTPA)\u2010bis (amide) analogs have been synthesized and evaluated as a potential biomedical imaging agents. Imaging and biodistribution studies were performed in mice that showed a significant accumulation of DTPA analogs in brain. The stability and protonation constants of the complexes formed between the ligand [DTPA\u2010(Me\u2010Trp)\n                    <jats:sub>2<\/jats:sub>\n                    ] and Gd\n                    <jats:sup>3+<\/jats:sup>\n                    , Eu\n                    <jats:sup>3+<\/jats:sup>\n                    , and Cu\n                    <jats:sup>2+<\/jats:sup>\n                    have been determined by pH potentiometry (Gd\n                    <jats:sup>3+<\/jats:sup>\n                    , Eu\n                    <jats:sup>3+<\/jats:sup>\n                    ) and spectrophotometry (Cu\n                    <jats:sup>2+<\/jats:sup>\n                    ) at 25\u2003\u00b0C and at constant ionic strength maintained by 0.10\u2003\n                    <jats:sc>m<\/jats:sc>\n                    KCl. The kinetic inertness of Gd [DTPA\u2010(Me\u2010Trp)\n                    <jats:sub>2<\/jats:sub>\n                    ] was characterized by the rates of exchange reactions with Zn\n                    <jats:sup>2+<\/jats:sup>\n                    and Eu\n                    <jats:sup>3+<\/jats:sup>\n                    . In the Eu\n                    <jats:sup>3+<\/jats:sup>\n                    exchange, a second\u2010order [H\n                    <jats:sup>+<\/jats:sup>\n                    ] dependence was found for the pseudo\u2010first\u2010order rate constant [\n                    <jats:italic>k<\/jats:italic>\n                    <jats:sub>0<\/jats:sub>\n                    = (4.5 \u00b1 1.2) \u00d7 10\n                    <jats:sup>\u22126<\/jats:sup>\n                    \/s;\n                    <jats:italic>k<\/jats:italic>\n                    <jats:sub>1<\/jats:sub>\n                    = 0.58 \u00b1 0.1 \/\n                    <jats:sc>m<\/jats:sc>\n                    \/s,\n                    <jats:italic>k<\/jats:italic>\n                    <jats:sub>2<\/jats:sub>\n                    = (6.6 \u00b1 0.2) \u00d7 10\n                    <jats:sup>4<\/jats:sup>\n                    \/\n                    <jats:sc>m<\/jats:sc>\n                    <jats:sup>2<\/jats:sup>\n                    \/s,\n                    <jats:italic>k<\/jats:italic>\n                    <jats:sub>3<\/jats:sub>\n                    = (4.8 \u00b1 0.8) \u00d7 10\n                    <jats:sup>\u22124<\/jats:sup>\n                    \/\n                    <jats:sc>m<\/jats:sc>\n                    \/s]. In the Eu\n                    <jats:sup>3+<\/jats:sup>\n                    exchange, at pH\n                    <jats:italic>&lt;<\/jats:italic>\n                    5.0, the rate decreases with increasing concentration of the exchanging ion. At physiological pH, the kinetic inertness of [DTPA\u2010(Me\u2010Trp)\n                    <jats:sub>2<\/jats:sub>\n                    ] is more inert than GdDTPA\n                    <jats:sup>2\u2212<\/jats:sup>\n                    , the most commonly used MRI contrast agent (\n                    <jats:italic>t<\/jats:italic>\n                    <jats:sub>\n                      1\n                      <jats:italic>\/<\/jats:italic>\n                      2\n                    <\/jats:sub>\n                    \u2003=\u2003127\u2003h). High kinetic stability is an important requirement for the Gd complexes used as contrast enhancement agents in magnetic resonance imaging.\n                  <\/jats:p>","DOI":"10.1111\/j.1747-0285.2011.01103.x","type":"journal-article","created":{"date-parts":[[2011,2,19]],"date-time":"2011-02-19T02:55:23Z","timestamp":1298084123000},"page":"388-392","source":"Crossref","is-referenced-by-count":7,"title":["<i>Retracted:<\/i>\n                    Kinetics of Formation for Lanthanide (III) Complexes of DTPA\u2010(Me\u2010Trp)\n                    <sub>2<\/sub>\n                    used as Imaging Agent"],"prefix":"10.1111","volume":"77","author":[{"given":"Anjani K.","family":"Tiwari","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Deepa","family":"Sinha","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anupama","family":"Datta","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dipti","family":"Kakkar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anil K.","family":"Mishra","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2011,3,25]]},"reference":[{"key":"e_1_2_7_2_2","doi-asserted-by":"publisher","DOI":"10.2174\/156800906776842984"},{"key":"e_1_2_7_3_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00259-001-0716-y"},{"key":"e_1_2_7_4_2","doi-asserted-by":"publisher","DOI":"10.2174\/157341206778699555"},{"key":"e_1_2_7_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0969-8051(97)00066-8"},{"key":"e_1_2_7_6_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00253516"},{"key":"e_1_2_7_7_2","doi-asserted-by":"publisher","DOI":"10.1248\/cpb.54.1203"},{"key":"e_1_2_7_8_2","doi-asserted-by":"publisher","DOI":"10.1021\/ic800450v"},{"key":"e_1_2_7_9_2","doi-asserted-by":"publisher","DOI":"10.1021\/ic00096a036"},{"key":"e_1_2_7_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.chemer.2010.01.003"},{"key":"e_1_2_7_11_2","doi-asserted-by":"publisher","DOI":"10.1002\/ejic.200901261"},{"key":"e_1_2_7_12_2","doi-asserted-by":"publisher","DOI":"10.1351\/pac200577081445"},{"key":"e_1_2_7_13_2","first-page":"26","volume-title":"Kinetics and Mechanisms of Reactions of Transition Metal Complexes","author":"Wilkins R.G.","year":"1974"},{"key":"e_1_2_7_14_2","volume-title":"The Chemistry of Contrast Agents in Medical Magnetic Resonance Imaging","author":"Merbach A.E.","year":"2001"},{"key":"e_1_2_7_15_2","doi-asserted-by":"publisher","DOI":"10.1039\/B418991D"},{"key":"e_1_2_7_16_2","doi-asserted-by":"publisher","DOI":"10.1002\/chem.200801803"},{"key":"e_1_2_7_17_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1747-0285.2009.00839.x"},{"key":"e_1_2_7_18_2","doi-asserted-by":"publisher","DOI":"10.1089\/cbr.2008.0597"},{"key":"e_1_2_7_19_2","doi-asserted-by":"publisher","DOI":"10.1089\/cbr.2009.0663"},{"key":"e_1_2_7_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmcl.2007.02.071"}],"updated-by":[{"DOI":"10.1111\/cbdd.14289","type":"retraction","label":"Retraction","source":"publisher","updated":{"date-parts":[[2023,7,13]],"date-time":"2023-07-13T00:00:00Z","timestamp":1689206400000}}],"container-title":["Chemical Biology &amp; Drug Design"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1747-0285.2011.01103.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1747-0285.2011.01103.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,17]],"date-time":"2023-08-17T17:08:05Z","timestamp":1692292085000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1747-0285.2011.01103.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,3,25]]},"references-count":19,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2011,5]]}},"alternative-id":["10.1111\/j.1747-0285.2011.01103.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1747-0285.2011.01103.x","archive":["Portico"],"relation":{},"ISSN":["1747-0277","1747-0285"],"issn-type":[{"value":"1747-0277","type":"print"},{"value":"1747-0285","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,3,25]]}}}