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Resveratrol, catechin, silymarin, dobutamin, and curcumin showed <jats:italic>K<\/jats:italic><jats:sub>I<\/jats:sub> values in the range of 4.47\u20139.47\u2003m<jats:sc>m<\/jats:sc> for hCA I and of 2.86\u20137.44\u2003\u03bc<jats:sc>m<\/jats:sc> against hCA II, respectively. These natural product phenols were generally competitive inhibitors with 4\u2010nitrophenylacetate as substrate. Some natural phenols investigated here showed effective hCA II inhibitory effects, in the same range as the clinically used sulfonamide acetazolamide, and might be used as leads for generating enzyme inhibitors possibly targeting other CA isoforms that have not been yet assayed for their interactions with such agents.<\/jats:p>","DOI":"10.1111\/j.1747-0285.2011.01104.x","type":"journal-article","created":{"date-parts":[[2011,2,19]],"date-time":"2011-02-19T07:55:33Z","timestamp":1298102133000},"page":"494-499","source":"Crossref","is-referenced-by-count":186,"title":["<i>In Vitro<\/i> Inhibition of Human Carbonic Anhydrase I and II Isozymes with Natural Phenolic 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