{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,9]],"date-time":"2026-02-09T19:29:21Z","timestamp":1770665361616,"version":"3.49.0"},"reference-count":24,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2011,11,4]],"date-time":"2011-11-04T00:00:00Z","timestamp":1320364800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Chem Biol Drug Des"],"published-print":{"date-parts":[[2012,1]]},"abstract":"<jats:p>The fact that ethosuximide (ETO), phenobarbital (PHO), and barbituric acid (BARB) share structural and pharmacophoric homologies with phenytoin and allantoin, both known to have significant wound\u2010healing properties, prompted us to evaluate them as wound\u2010healing agents. Accordingly, ETO\u2010, PHO\u2010, and BARB\u2010containing ointments were applied onto full\u2010thickness excision and incision wounds created on the dorso\u2010lumbar region of experimental rats. ETO\u2010and PHO\u2010treated incision wounds illustrated significant enhancement in breaking strengths (1380\u2003\u00b1\u200361 and 1240\u2003\u00b1\u200342\u2003g, respectively) compared to vehicle controls (1070\u2003\u00b1\u200318\u2003g) and BARB (1080\u2003\u00b1\u200345\u2003g). Moreover, biochemical analyses revealed significant increase in hydroxyproline contents in ETO\u2010 and PHO\u2010treated wounds compared to vehicle controls. Histological evaluation revealed that both ETO and PHO promoted collagen synthesis and deposition. This is the first time to describe the significant wound\u2010healing merits of ETO and PHO as potential clinical agents for treatment of chronic wounds.<\/jats:p>","DOI":"10.1111\/j.1747-0285.2011.01105.x","type":"journal-article","created":{"date-parts":[[2011,2,19]],"date-time":"2011-02-19T07:56:25Z","timestamp":1298102185000},"page":"137-142","source":"Crossref","is-referenced-by-count":7,"title":["Ethosuximide and Phenobarbital Promote Wound Healing via Enhancing Collagenization"],"prefix":"10.1111","volume":"79","author":[{"given":"Dema M.","family":"Ajwee","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ahmad M.","family":"Disi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eyad A.","family":"Qunaibi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mutasem O.","family":"Taha","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2011,11,4]]},"reference":[{"key":"e_1_2_7_2_2","volume-title":"Wound Healing Principles and Practice","author":"Irvin T.","year":"1981"},{"key":"e_1_2_7_3_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.276.5309.75"},{"key":"e_1_2_7_4_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199909023411006"},{"key":"e_1_2_7_5_2","doi-asserted-by":"publisher","DOI":"10.1517\/14728214.11.1.23"},{"key":"e_1_2_7_6_2","doi-asserted-by":"publisher","DOI":"10.2337\/diacare.22.3.382"},{"key":"e_1_2_7_7_2","first-page":"22","article-title":"Prevalence of pressure ulcers in Canadian health\u2010care settings","volume":"50","author":"Woodbury M.G.","year":"2004","journal-title":"Ostomy Wound Manage"},{"key":"e_1_2_7_8_2","first-page":"584","article-title":"Phenytoin enhances collagenization in excision wounds and tensile strength in incision wounds","volume":"64","author":"Qunaibi E.A.","year":"2009","journal-title":"Pharmazie"},{"key":"e_1_2_7_9_2","first-page":"5","article-title":"Topical phenytoin for wound healing","volume":"10","author":"Ashima B.","year":"2004","journal-title":"Dermatol Online J"},{"key":"e_1_2_7_10_2","first-page":"1305","article-title":"Action of allantoin on the granulation of wounds in the skin of rats","volume":"7","author":"Fukawa K.","year":"1973","journal-title":"Oyo Yakuri"},{"key":"e_1_2_7_11_2","doi-asserted-by":"publisher","DOI":"10.3923\/ajb.2006.178.185"},{"key":"e_1_2_7_12_2","doi-asserted-by":"publisher","DOI":"10.1002\/0471701343"},{"key":"e_1_2_7_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/0041-008X(71)90328-0"},{"key":"e_1_2_7_14_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.0013-9580.2004.12704.x"},{"key":"e_1_2_7_15_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1528-1167.2009.02042.x"},{"key":"e_1_2_7_16_2","doi-asserted-by":"publisher","DOI":"10.1055\/s-2006-961907"},{"key":"e_1_2_7_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/0003-9861(61)90291-0"},{"key":"e_1_2_7_18_2","volume-title":"The Nucleic Acids: Chemistry and Biology","author":"Bendich A.","year":"1955"},{"key":"e_1_2_7_19_2","doi-asserted-by":"publisher","DOI":"10.1097\/00005373-196409000-00001"},{"key":"e_1_2_7_20_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000658-196502000-00019"},{"key":"e_1_2_7_21_2","volume-title":"Quarterly Medical Review","author":"Gupta S.","year":"1985"},{"key":"e_1_2_7_22_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000658-199406000-00012"},{"key":"e_1_2_7_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.clindermatol.2006.09.007"},{"key":"e_1_2_7_24_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2003.12.146"},{"key":"e_1_2_7_25_2","volume-title":"Principles of Laboratory Animal Care","author":"National Institutes of Health","year":"1985"}],"container-title":["Chemical Biology &amp; 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