{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T10:56:20Z","timestamp":1790074580682,"version":"4.0.1"},"reference-count":32,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2011,5,31]],"date-time":"2011-05-31T00:00:00Z","timestamp":1306800000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Chem Biol Drug Des"],"published-print":{"date-parts":[[2011,7]]},"abstract":"<jats:p>A series of novel Mannich bases with trifluoromethyl\u20101,2,4\u2010triazole and substituted benzylpiperazine moieties were synthesized. Their structures were confirmed by IR, <jats:sup>1<\/jats:sup>H NMR and elemental analysis. The single crystal structure of compound 4r was also determined. The preliminary bioassays showed that most of the lead compounds had low herbicidal activity against <jats:italic>Brassica campestris<\/jats:italic>, <jats:italic>Echinochloa crusgalli<\/jats:italic>, and KARI enzyme. However, most of them exhibited significant fungicidal activity at the dosage of 50\u2003\u03bcg\/mL toward five test fungi. Among the 18 novel compounds, several showed superiority over the commercial fungicide Triadimefon against <jats:italic>Cercospora arachidicola<\/jats:italic> and <jats:italic>Fusarium oxysporum<\/jats:italic> f. sp. <jats:italic>cucumerinum<\/jats:italic> during this study. Meanwhile, some compounds displayed plant growth regulatory activity at the dosage of 10\u2003\u03bcg\/mL.<\/jats:p>","DOI":"10.1111\/j.1747-0285.2011.01132.x","type":"journal-article","created":{"date-parts":[[2011,4,26]],"date-time":"2011-04-26T14:46:59Z","timestamp":1303829219000},"page":"42-49","source":"Crossref","is-referenced-by-count":47,"title":["Synthesis, Structure and Biological Activity of Novel 1,2,4\u2010Triazole Mannich Bases Containing a Substituted Benzylpiperazine Moiety"],"prefix":"10.1111","volume":"78","author":[{"given":"Bao\u2010Lei","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xing\u2010Hai","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiu\u2010Lan","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ji\u2010Feng","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hai\u2010Bin","family":"Song","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zheng\u2010Ming","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2011,5,31]]},"reference":[{"key":"e_1_2_5_2_2","first-page":"1000","article-title":"Synthesis and fungitoxicity of new 1,3,4\u2010oxadiazolo[3,2\u2010a]\u2010s\u2010triazine\u20105,7\u2010diones and their thione analogues","volume":"26","author":"Singh H.","year":"1987","journal-title":"Indian J Chem"},{"key":"e_1_2_5_3_2","first-page":"135","article-title":"A novel synthesis of a few substituted s\u2010triazolo[3,4\u2010b]1,3,4\u2010thiadiazoles and evaluation of their antibacterial activity","volume":"29","author":"Patel H.V.","year":"1990","journal-title":"Indian J Chem"},{"key":"e_1_2_5_4_2","doi-asserted-by":"publisher","DOI":"10.1080\/10426508908046079"},{"key":"e_1_2_5_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2004.06.007"},{"key":"e_1_2_5_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.saa.2003.12.008"},{"key":"e_1_2_5_7_2","first-page":"14","article-title":"Synthesis and plant growth regulating activity of 1\u2010(1\u2010phenyl\u20101,2,4\u2010triazole\u20103\u2010oxy acetoxy)alkyl phosphonates","volume":"4","author":"He H.W.","year":"2002","journal-title":"Chin J Pest Sci"},{"key":"e_1_2_5_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/0378-4274(95)03618-0"},{"key":"e_1_2_5_9_2","doi-asserted-by":"publisher","DOI":"10.1021\/jf8026843"},{"key":"e_1_2_5_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0890-6238(01)00143-5"},{"key":"e_1_2_5_11_2","doi-asserted-by":"publisher","DOI":"10.1021\/jf00014a027"},{"key":"e_1_2_5_12_2","first-page":"4","article-title":"Research advances on triazole compounds bearing biological activities","volume":"42","author":"Li X.\u2010Z.","year":"2003","journal-title":"Pesticides"},{"key":"e_1_2_5_13_2","doi-asserted-by":"publisher","DOI":"10.3184\/030823406780199703"},{"key":"e_1_2_5_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmc.2005.10.032"},{"key":"e_1_2_5_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmc.2004.02.014"},{"key":"e_1_2_5_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmc.2006.07.015"},{"key":"e_1_2_5_17_2","first-page":"459","article-title":"Synthesis and biological evaluation of some Mannich bases derived from 1,2,4\u2010triazole derivatives","volume":"6","author":"Satyanarayana D.","year":"2002","journal-title":"J Saudi Chem Soc"},{"key":"e_1_2_5_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0968-0896(03)00499-1"},{"key":"e_1_2_5_19_2","doi-asserted-by":"publisher","DOI":"10.1002\/jhet.5570230521"},{"key":"e_1_2_5_20_2","first-page":"738","article-title":"Synthesis of trifluoromethyl\u2010substituted 1,2,4\u2010triazole mannich bases","volume":"20","author":"Liu F.M.","year":"2000","journal-title":"Chin J Org Chem"},{"key":"e_1_2_5_21_2","doi-asserted-by":"publisher","DOI":"10.1021\/jm00286a016"},{"key":"e_1_2_5_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/0223-5234(96)85875-2"},{"key":"e_1_2_5_23_2","doi-asserted-by":"publisher","DOI":"10.1021\/ja01230a031"},{"key":"e_1_2_5_24_2","unstructured":"ShapiroS.L. 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