{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,5]],"date-time":"2026-11-05T08:26:29Z","timestamp":1793867189148,"version":"4.6.1"},"reference-count":70,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2011,9,6]],"date-time":"2011-09-06T00:00:00Z","timestamp":1315267200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Chem Biol Drug Des"],"published-print":{"date-parts":[[2011,10]]},"abstract":"<jats:p>\n                    Eph receptor tyrosine kinases and ephrin ligands control many physiological and pathological processes, and molecules interfering with their interaction are useful probes to elucidate their complex biological functions. Moreover, targeting Eph receptors might enable new strategies to inhibit cancer progression and pathological angiogenesis as well as promote nerve regeneration. Because our previous work suggested the importance of the salicylic acid group in antagonistic small molecules targeting Eph receptors, we screened a series of salicylic acid derivatives to identify novel Eph receptor antagonists. This identified a disalicylic acid\u2010furanyl derivative that inhibits ephrin\u2010A5 binding to EphA4 with an IC\n                    <jats:sub>50<\/jats:sub>\n                    of 3\u2003\u03bc\n                    <jats:sc>m<\/jats:sc>\n                    in ELISAs. This compound, which appears to bind to the ephrin\u2010binding pocket of EphA4, also targets several other Eph receptors. Furthermore, it inhibits EphA2 and EphA4 tyrosine phosphorylation in cells stimulated with ephrin while not affecting phosphorylation of EphB2, which is not a target receptor. In endothelial cells, the disalicylic acid\u2010furanyl derivative inhibits EphA2 phosphorylation in response to TNF\u03b1 and capillary\u2010like tube formation on Matrigel, two effects that depend on EphA2 interaction with endogenous ephrin\u2010A1. These findings suggest that salicylic acid derivatives could be used as starting points to design new small molecule antagonists of Eph receptors.\n                  <\/jats:p>","DOI":"10.1111\/j.1747-0285.2011.01199.x","type":"journal-article","created":{"date-parts":[[2011,7,26]],"date-time":"2011-07-26T09:44:36Z","timestamp":1311673476000},"page":"667-678","source":"Crossref","is-referenced-by-count":38,"title":["A Disalicylic Acid\u2010Furanyl Derivative Inhibits Ephrin Binding to a Subset of Eph Receptors"],"prefix":"10.1111","volume":"78","author":[{"given":"Roberta","family":"Noberini","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Surya K.","family":"De","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ziming","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bainan","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dhanya","family":"Raveendra\u2010Panickar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vida","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jesus","family":"Vazquez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haina","family":"Qin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianxing","family":"Song","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicholas D. 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