{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,26]],"date-time":"2026-03-26T17:38:32Z","timestamp":1774546712703,"version":"3.50.1"},"reference-count":17,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2011,8,29]],"date-time":"2011-08-29T00:00:00Z","timestamp":1314576000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Chem Biol Drug Des"],"published-print":{"date-parts":[[2011,10]]},"abstract":"<jats:p>A series of new <jats:italic>N<\/jats:italic>,<jats:italic>N<\/jats:italic>\u2032\u2010diacylhydrazine derivatives were synthesized efficiently under microwave irradiation. Their structures were characterized by <jats:sup>1<\/jats:sup>H NMR, MS, and elemental analysis. Various biological activities of these compounds were tested. Most of them exhibited higher herbicidal activities against dicotyledonous weeds than monocotyledonous weeds. In addition, favorable <jats:italic>in vivo<\/jats:italic> fungicidal activities were also found of these compounds against <jats:italic>Cladosporium cucumerinum<\/jats:italic>, <jats:italic>Corynespora cassiicola<\/jats:italic>, <jats:italic>Sclerotinia sclerotiorum<\/jats:italic>(Lib.)de Bary, <jats:italic>Erysiphe cichoracearum<\/jats:italic>, and <jats:italic>Colletotrichum orbiculare<\/jats:italic> (Berk aLMont) Arx. All compounds displayed excellent plant growth regulatory activities: 100% inhibition was achieved against the radicle growth of cucumber. To further investigate the structure\u2013activity relationship, comparative molecular field analysis was performed on the basis of herbicidal activity data, resulting in a statistically reliable model with good predictive power (<jats:italic>r<\/jats:italic><jats:sup>2\u2003<\/jats:sup>=<jats:sup>\u2003<\/jats:sup>0.913, <jats:italic>q<\/jats:italic><jats:sup>2\u2003<\/jats:sup>=<jats:sup>\u2003<\/jats:sup>0.556). Based on the calculation, five additional novel compounds were designed and synthesized. Satisfyingly, compound <jats:bold>4u<\/jats:bold> displayed excellent herbicidal activity (94.7%) at 1500\u2003g\/ha, although it is less active than 2,4\u2010D. Meanwhile, this compound also exhibited good fungicidal activity against <jats:italic>C.\u00a0orbiculare<\/jats:italic> (Berk aLMont) Arx (82.16%).<\/jats:p>","DOI":"10.1111\/j.1747-0285.2011.01205.x","type":"journal-article","created":{"date-parts":[[2011,8,4]],"date-time":"2011-08-04T20:29:33Z","timestamp":1312489773000},"page":"689-694","source":"Crossref","is-referenced-by-count":56,"title":["Design, Synthesis, Biological Activities, and 3D\u2010QSAR of New <i>N<\/i>,<i>N<\/i>\u2032\u2010Diacylhydrazines Containing 2\u2010(2,4\u2010dichlorophenoxy)propane Moiety"],"prefix":"10.1111","volume":"78","author":[{"given":"Xing\u2010Hai","family":"Liu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Li","family":"Pan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yi","family":"Ma","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jian\u2010Quan","family":"Weng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cheng\u2010Xia","family":"Tan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yong\u2010Hong","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yan\u2010Xia","family":"Shi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bao\u2010Ju","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zheng\u2010Ming","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yong\u2010Gang","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2011,8,29]]},"reference":[{"key":"e_1_2_5_2_2","first-page":"115","article-title":"Synthesis and herbicidal activity of some new pyrazolyl amido urea derivatives","volume":"13","author":"Tan C.X.","year":"2011","journal-title":"Chin J Pestic Sci"},{"key":"e_1_2_5_3_2","first-page":"1100","article-title":"Synthesis and biological activities of Novel N\u2010[cis\u20103\u2010(2\u2010Chloro\u20103,3,3\u2010trifluoropropenyl)\u20102,2\u2010dimethylcyclopropylcarbonyl]\u2010N\u2032\u2010(aryloxyacetyl)hydrazines","volume":"29","author":"Liu M.","year":"2009","journal-title":"Chin J Org Chem"},{"key":"e_1_2_5_4_2","unstructured":"CaiC.Q. 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