{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T10:57:13Z","timestamp":1791284233158,"version":"4.1.0"},"reference-count":37,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2012,1,30]],"date-time":"2012-01-30T00:00:00Z","timestamp":1327881600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Chem Biol Drug Des"],"published-print":{"date-parts":[[2012,4]]},"abstract":"<jats:p>Schistosomiasis, a high volume neglected tropical disease affecting more than 200 million people worldwide, can only be effectively treated by the tetrahydroisoquinoline drug praziquantel (PZQ). Herein, we describe an efficient approach to access PZQ derivatives by the Ugi 4\u2010component reaction followed by the Pictet\u2013Spengler reaction in a two\u2010step, one\u2010pot procedure. 30 novel PZQ derivatives are described based on the Ugi 4\u2010component reaction and an X\u2010ray structure of a novel derivative revealing different conformation compared with PZQ is discussed. Several analogues comparable in activity to the drug PZQ have been identified based on an <jats:italic>in vitro<\/jats:italic> Schistosoma mansoni worm viability assay.<\/jats:p>","DOI":"10.1111\/j.1747-0285.2011.01288.x","type":"journal-article","created":{"date-parts":[[2011,12,8]],"date-time":"2011-12-08T20:58:18Z","timestamp":1323377898000},"page":"470-477","source":"Crossref","is-referenced-by-count":74,"title":["MCR Synthesis of Praziquantel Derivatives"],"prefix":"10.1111","volume":"79","author":[{"given":"Haixia","family":"Liu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samia","family":"William","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eberhardt","family":"Herdtweck","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sanaa","family":"Botros","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander","family":"D\u00f6mling","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2012,1,30]]},"reference":[{"key":"e_1_2_5_2_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra064142"},{"key":"e_1_2_5_3_2","first-page":"804","volume-title":"Hunter\u2019s Tropical Medicine and Emerging Infectious Diseases","author":"Strickland G.T.","year":"2000"},{"key":"e_1_2_5_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0001-706X(03)00029-9"},{"key":"e_1_2_5_5_2","doi-asserted-by":"publisher","DOI":"10.1177\/095646249400500517"},{"key":"e_1_2_5_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0001-706X(01)00086-9"},{"key":"e_1_2_5_7_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.aids.0000210614.45212.0a"},{"key":"e_1_2_5_8_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0000430"},{"key":"e_1_2_5_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.pt.2007.08.015"},{"key":"e_1_2_5_10_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF01945954"},{"key":"e_1_2_5_11_2","doi-asserted-by":"publisher","DOI":"10.3987\/R-1983-09-1731"},{"key":"e_1_2_5_12_2","doi-asserted-by":"publisher","DOI":"10.1021\/jo00200a057"},{"key":"e_1_2_5_13_2","doi-asserted-by":"publisher","DOI":"10.1002\/jhet.5570230139"},{"key":"e_1_2_5_14_2","doi-asserted-by":"publisher","DOI":"10.3987\/COM-98-8293"},{"key":"e_1_2_5_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0040-4020(98)00401-3"},{"key":"e_1_2_5_16_2","doi-asserted-by":"publisher","DOI":"10.1021\/jo010990m"},{"key":"e_1_2_5_17_2","doi-asserted-by":"publisher","DOI":"10.1002\/cmdc.201000202"},{"key":"e_1_2_5_18_2","doi-asserted-by":"publisher","DOI":"10.1002\/1521-3773(20000915)39:18<3168::AID-ANIE3168>3.0.CO;2-U"},{"key":"e_1_2_5_19_2","doi-asserted-by":"publisher","DOI":"10.1021\/cr0505728"},{"key":"e_1_2_5_20_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1747-0285.2009.00854.x"},{"key":"e_1_2_5_21_2","doi-asserted-by":"publisher","DOI":"10.1002\/ange.19600720709"},{"key":"e_1_2_5_22_2","doi-asserted-by":"publisher","DOI":"10.1038\/nprot.2007.71"},{"key":"e_1_2_5_23_2","doi-asserted-by":"publisher","DOI":"10.1002\/cber.19110440309"},{"key":"e_1_2_5_24_2","doi-asserted-by":"publisher","DOI":"10.1021\/cr00038a004"},{"key":"e_1_2_5_25_2","doi-asserted-by":"publisher","DOI":"10.1002\/ange.19580702213"},{"key":"e_1_2_5_26_2","doi-asserted-by":"publisher","DOI":"10.1002\/jlac.18671440116"},{"key":"e_1_2_5_27_2","doi-asserted-by":"publisher","DOI":"10.1002\/anie.197205301"},{"key":"e_1_2_5_28_2","doi-asserted-by":"publisher","DOI":"10.1021\/jm801529c"},{"key":"e_1_2_5_29_2","doi-asserted-by":"publisher","DOI":"10.1002\/chem.201002046"},{"key":"e_1_2_5_30_2","doi-asserted-by":"publisher","DOI":"10.1021\/jo900986z"},{"key":"e_1_2_5_31_2","doi-asserted-by":"publisher","DOI":"10.1021\/cr0306182"},{"key":"e_1_2_5_32_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF01128018"},{"key":"e_1_2_5_33_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpara.2004.09.004"},{"key":"e_1_2_5_34_2","doi-asserted-by":"publisher","DOI":"10.1097\/QCO.0b013e328318978f"},{"key":"e_1_2_5_35_2","doi-asserted-by":"publisher","DOI":"10.4269\/ajtmh.1967.16.483"},{"key":"e_1_2_5_36_2","first-page":"34","article-title":"Laboratory cultivation of schistosome vector snails and maintenance of schistosome life cycle","volume":"1","author":"Liang Y.S.","year":"1987","journal-title":"Proc First Sino-Am Symp"},{"key":"e_1_2_5_37_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpara.2005.05.002"},{"key":"e_1_2_5_38_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(08)61358-6"}],"container-title":["Chemical Biology &amp; 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