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A total of 0.2 g of each MTA was digested using a mixture of hydrochloric and nitric acids and filtered. Six heavy metals in the resulting filtrates were analyzed by inductively coupled plasma\u2013optical emission spectrometry (<jats:italic>n<\/jats:italic>\u2003=\u20035). The results were statistically analyzed using the Mann\u2013Whitney <jats:italic>U<\/jats:italic>\u2010test. The concentrations of Cd, Cu, Fe, Mn, Ni and Zn in Ortho MTA were 0.10, 7.73, 49.51, 2.58, 0.82 and 10.09\u2003p.p.m., respectively. The concentrations of Cd, Cu, Fe, Mn, Ni and Zn in ProRoot MTA were 0.16, 9.38, 1438.11, 74.51, 18.98 and 4.05\u2003p.p.m., respectively. 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