{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,11,12]],"date-time":"2023-11-12T00:10:20Z","timestamp":1699747820730},"reference-count":19,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2008,12,8]],"date-time":"2008-12-08T00:00:00Z","timestamp":1228694400000},"content-version":"vor","delay-in-days":9565,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acta Physiologica Scandinavica"],"published-print":{"date-parts":[[1982,10]]},"abstract":"<jats:p>The gastrin concentration in the proximal third of the duodenum was found to be increased in dogs following antrectomy with gastrojejunostomy. The level found 13\u201315 weeks after operation was, using a COOH\u2010terminal directed antiserum, 27.8\u00b14.5 pmol\/g tissue wet weight (mean value \u00b1 SE, n=5), which is approximately 4 times higher than the concentration found in the same tissue of unoperated dogs. In the middle and distal thirds of the duodenum the gastrin concentrations were 6.1\u00b10.6 and 5.2\u00b10.2 pmol\/g (n=5), respectively. These values are not significantly different from those of the corresponding tissues of unoperated dogs. The gastrin concentration was also determined in different parts of the jejunum. In specimens taken close to the gastrojejunostomy, the gastrin level was 1.9\u00b10.2 pmol\/g,\u2010which was not significantly different from that in more proximal (3.0\u00b10.3) or distal (1.7\u00b10.2) parts of the jejunum in the same animals. Basal plasma gastrin concentration as measured with the same COOH\u2010terminal directed antiserum, was reduced after surgery to 35% (mean value) of the preoperative level and remained low throughout the postoperative period. In contrast to this, using an antiserum directed against the NH<jats:sub>2<\/jats:sub>\u2010terminal portion of gastrin\u201017, the plasma gastrin concentration was found to be decreased to 70% 1\u20132 days after antrectomy and then to increase again and remain at approximately the preoperative level. The plasma gastrin concentrations measured with this antiserum, were consistently much higher than those measured with the COOH\u2010terminal directed antiserum. In a previous study we have shown that the gastrin concentration in the proximal third of the canine duodenum is increased 20\u2010fold at 14\u201316 weeks after antrectomy with gastroduodenostomy. In the present study it is shown that there is a less prominent increase after antrectomy with gastrojejunostomy. These results indicate that the presence of food and gastric juice in the duodenum might be of importance for the increase in duodenal gastrin after antrectomy.<\/jats:p>","DOI":"10.1111\/j.1748-1716.1982.tb07124.x","type":"journal-article","created":{"date-parts":[[2008,12,9]],"date-time":"2008-12-09T20:12:11Z","timestamp":1228853531000},"page":"153-158","source":"Crossref","is-referenced-by-count":5,"title":["Gastrin in duodenal and jejunal tissue and in plasma following antrectomy with gastrojejunostomy"],"prefix":"10.1111","volume":"116","author":[{"given":"KERSTIN","family":"BRODIN","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G\u00d6RAN","family":"NILSSON","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2008,12,8]]},"reference":[{"key":"e_1_2_1_2_1","first-page":"778","article-title":"Influence of vagotomy on tissue gastrin levels in the stomach and pancreas in rats","volume":"74","author":"BECKER H. 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