{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,3]],"date-time":"2025-08-03T22:55:50Z","timestamp":1754261750350},"reference-count":49,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2006,4,5]],"date-time":"2006-04-05T00:00:00Z","timestamp":1144195200000},"content-version":"vor","delay-in-days":4,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acta Physiologica"],"published-print":{"date-parts":[[2006,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:bold>Aim:\u2002<\/jats:bold> To determine the roles of myostatin and insulin\u2010like growth factor\u2010I (IGF\u2010I) during postnatal growth, we examined IGF\u2010I and myostatin mRNA expression in the skeletal muscles of hypophysectomized and underfed rats during postnatal growth.<\/jats:p><jats:p><jats:bold>Methods:\u2002<\/jats:bold> Five\u2010week\u2010old rats were divided into four groups: freely fed control, moderately underfed, severely underfed and hypophysectomized. Four weeks later, blood and muscle samples were gathered to determine serum IGF\u2010I, myosin heavy chain (MHC) isoforms, IGF\u2010I Ea, IGF\u2010I Eb and myostatin mRNA.<\/jats:p><jats:p><jats:bold>Results:\u2002<\/jats:bold> The weights of soleus, plantaris and masseter muscles were decreased in underfed and hypophysectomized rats. Hypophysectomy resulted in significant increases of type I MHC at the expense of type IIx in plantaris muscle and of neonatal MHC at the expense of types IIx and IIb in masseter muscle. Serum IGF\u2010I was decreased by underfeeding and hypophysectomy. Plantaris muscle IGF\u2010I Ea mRNA in underfed and hypophysectomized rats was significantly lower than in normal controls. Plantaris muscle IGF\u2010I Eb mRNA in underfed rats was significantly lower than in normal controls. Masseter muscle IGF\u2010I Eb mRNA in severely underfed rats was significantly lower than in normal control and hypophysectomized rats. Soleus muscle myostatin mRNA in hypophysectomized rats was significantly higher than in normal and significantly underfed rats. No significant differences in plantaris and masseter muscle myostatin mRNA were observed between groups.<\/jats:p><jats:p><jats:bold>Conclusion:\u2002<\/jats:bold> Suppressed muscle growth caused by hypophysectomy and underfeeding may be attributed mainly to reduced circulating IGF\u2010I and partially to reduced IGF\u2010I mRNA, rather than to a change in myostatin.<\/jats:p>","DOI":"10.1111\/j.1748-1716.2006.01569.x","type":"journal-article","created":{"date-parts":[[2006,4,5]],"date-time":"2006-04-05T14:43:36Z","timestamp":1144248216000},"page":"291-300","source":"Crossref","is-referenced-by-count":11,"title":["The expression of IGF\u2010I and myostatin mRNAs in skeletal muscle of hypophysectomized and underfed rats during postnatal 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