{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T19:33:08Z","timestamp":1790969588252,"version":"4.1.0"},"reference-count":20,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2006,10,26]],"date-time":"2006-10-26T00:00:00Z","timestamp":1161820800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acta Physiologica"],"published-print":{"date-parts":[[2007,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:bold>Aim:\u2002<\/jats:bold> The purpose of this study was to determine whether anaphylactic hypotension in rabbits is accompanied by hepatic venoconstriction, and the effects of anaphylaxis on hepatic segmental vascular resistances and liver weight in isolated perfused rabbit livers.<\/jats:p><jats:p><jats:bold>Methods:\u2002<\/jats:bold> The rabbits were sensitized by subcutaneous injection of antigen of 2.5\u2003mg ovalbumin with complete Freund's adjuvant three times at 1\u2003week interval. One week after sensitization, anaphylaxis was induced by an injection of 2.5\u2003mg ovalbumin into the jugular vein of pentobarbital anaesthetized rabbits or the perfusate of rabbit livers perfused via the portal vein at a constant flow. Using the double occlusion technique to estimate the hepatic sinusoidal pressure, pre\u2010 (<jats:italic>R<\/jats:italic><jats:sub>pre<\/jats:sub>) and post\u2010sinusoidal (<jats:italic>R<\/jats:italic><jats:sub>post<\/jats:sub>) resistances were calculated for the isolated perfused livers.<\/jats:p><jats:p><jats:bold>Results:\u2002<\/jats:bold> An antigen injection into the sensitized rabbits caused not only a decrease in systemic arterial pressure from 79\u2003\u00b1\u20032 to 40\u2003\u00b1\u20034\u2003mmHg, but also an increase in portal venous pressure (<jats:italic>P<\/jats:italic><jats:sub>pv<\/jats:sub>) from 9.5\u2003\u00b1\u20032.2 to 24.1\u2003\u00b1\u20033.9\u2003cmH<jats:sub>2<\/jats:sub>O. Portal hypertension persisted for 8\u2003min after the antigen injection. An injection of antigen into the perfusate caused a marked increase in <jats:italic>P<\/jats:italic><jats:sub>pv<\/jats:sub> from 5.4\u2003\u00b1\u20030.1 to 28.6\u2003\u00b1\u20032.4\u2003cmH<jats:sub>2<\/jats:sub>O at 6\u2003min, but only a slight increase in double occlusion pressure from 2.2\u2003\u00b1\u20030.2 to 3.8\u2003\u00b1\u20030.2\u2003cmH<jats:sub>2<\/jats:sub>O, resulting in a selective increase in <jats:italic>R<\/jats:italic><jats:sub>pret<\/jats:sub> rather than <jats:italic>R<\/jats:italic><jats:sub>post<\/jats:sub>. Concomitant with the hepatic pre\u2010sinusoidal constriction, liver weight loss occurred.<\/jats:p><jats:p><jats:bold>Conclusion:\u2002<\/jats:bold> Anaphylactic hypotension in rabbits is accompanied by hepatic venoconstriction which is characterized by pre\u2010sinusoidal contraction.<\/jats:p>","DOI":"10.1111\/j.1748-1716.2006.01629.x","type":"journal-article","created":{"date-parts":[[2006,10,26]],"date-time":"2006-10-26T13:42:30Z","timestamp":1161870150000},"page":"15-22","source":"Crossref","is-referenced-by-count":15,"title":["Hepatic pre\u2010sinusoidal vessels contract in anaphylactic hypotension in rabbits"],"prefix":"10.1111","volume":"189","author":[{"given":"N.","family":"Karasawa","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T.","family":"Shibamoto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Cui","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H.","family":"Takano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y.","family":"Kurata","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H.","family":"Tsuchida","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2006,10,26]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1136\/emj.12.2.89"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/0021-8707(51)90055-X"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-2007-1007126"},{"key":"e_1_2_8_5_1","first-page":"1519","volume-title":"Handbook of Physiology. 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