{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T17:29:31Z","timestamp":1791307771035,"version":"4.3.1"},"reference-count":45,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2011,10,31]],"date-time":"2011-10-31T00:00:00Z","timestamp":1320019200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acta Physiologica"],"published-print":{"date-parts":[[2012,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>\n            <jats:bold>Aim:\u2002<\/jats:bold> To investigate the effect of carbon monoxide (CO) in the inspired air as anticipated during peak hours of traffic in polluted megalopolises on cerebral, respiratory and leg muscle oxygenation during a constant\u2010power test (CPT). In addition, since O<jats:sub>2<\/jats:sub> breathing is used to hasten elimination of CO from the blood, we examined the effect of breathing O<jats:sub>2<\/jats:sub> following exposure to CO on cerebral and muscle oxygenation during a subsequent exercise test under CO conditions.<\/jats:p><jats:p>\n            <jats:bold>Methods:\u2002<\/jats:bold> Nine men participated in three trials: (i) 3\u2010h air exposure followed by a control CPT, (ii) 1\u2010h air and 2\u2010h CO (18.9\u2003ppm) exposure succeeded by a CPT under CO conditions (CPT<jats:sub>COA<\/jats:sub>), and (iii) 2\u2010h CO and 1\u2010h 100% normobaric O<jats:sub>2<\/jats:sub> exposure followed by a CPT under CO conditions (CPT<jats:sub>COB<\/jats:sub>). All exercise tests were performed at 85% of peak power output to exhaustion. Oxygenated (\u0394[O<jats:sub>2<\/jats:sub>Hb]), deoxygenated (\u0394[HHb]) and total (\u0394[tHb]) haemoglobin in cerebral, intercostal and vastus lateralis muscles were monitored with near\u2010infrared spectroscopy throughout the CPTs.<\/jats:p><jats:p>\n            <jats:bold>Results:\u2002<\/jats:bold> Performance time did not vary between trials. However, the vastus lateralis and intercostal \u0394[O<jats:sub>2<\/jats:sub>Hb] and \u0394[tHb] were lower in CPT<jats:sub>COA<\/jats:sub> than in CPT. During the CPT<jats:sub>COB<\/jats:sub>, the intercostal \u0394[O<jats:sub>2<\/jats:sub>Hb] and \u0394[tHb] were higher than in the CPT<jats:sub>COA<\/jats:sub>. There were no differences in cerebral oxygenation between the trials.<\/jats:p><jats:p>\n            <jats:bold>Conclusion:\u2002<\/jats:bold> Inspiration of 18.9\u2003ppm CO decreases oxygenation in the vastus lateralis and serratus anterior muscles, but does not affect performance. Breathing normobaric O<jats:sub>2<\/jats:sub> moderates the CO\u2010induced reductions in muscle oxygenation, mainly in the intercostals, but does not affect endurance.<\/jats:p>","DOI":"10.1111\/j.1748-1716.2011.02363.x","type":"journal-article","created":{"date-parts":[[2011,9,20]],"date-time":"2011-09-20T21:59:06Z","timestamp":1316555946000},"page":"544-554","source":"Crossref","is-referenced-by-count":18,"title":["Carbon monoxide exposure during exercise performance: muscle and cerebral oxygenation"],"prefix":"10.1111","volume":"204","author":[{"given":"M. E.","family":"Keramidas","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S. N.","family":"Kounalakis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"O.","family":"Eiken","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"I. 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