{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,7]],"date-time":"2025-11-07T19:00:37Z","timestamp":1762542037251,"version":"3.38.0"},"reference-count":37,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2012,1,25]],"date-time":"2012-01-25T00:00:00Z","timestamp":1327449600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acta Physiologica"],"published-print":{"date-parts":[[2012,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim:<\/jats:title><jats:p>This study evaluated the hypothesis that physiological maturation affects cerebral artery smooth muscle\u2013endothelial interactions involved in pressure\u2010induced tone and alters the dimensional and biomechanical properties of small posterior cerebral arteries (<jats:styled-content style=\"fixed-case\">PCA<\/jats:styled-content>).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods:<\/jats:title><jats:p>Secondary branches of<jats:styled-content style=\"fixed-case\">PCA<\/jats:styled-content>from young (4\u20135\u00a0weeks old,<jats:italic>n<\/jats:italic>\u00a0=\u00a011), adult (14\u201316\u00a0weeks old,<jats:italic>n<\/jats:italic>\u00a0=\u00a011) and mature (44\u201347\u00a0weeks old,<jats:italic>n<\/jats:italic>\u00a0=\u00a011) male<jats:styled-content style=\"fixed-case\">S<\/jats:styled-content>prague\u2010<jats:styled-content style=\"fixed-case\">D<\/jats:styled-content>awley rats were isolated, cannulated, pressurized and subjected to a range of intraluminal pressures (10\u2013110\u00a0mm<jats:styled-content style=\"fixed-case\"><jats:roman>Hg<\/jats:roman><\/jats:styled-content>) to determine tone with and without pharmacologic nitric oxide synthase (<jats:styled-content style=\"fixed-case\">NOS<\/jats:styled-content>) inhibition. Measurements of passive lumen diameter and wall thickness as a function of pressure were used to determine changes in structure, distensibility and wall stress; histological analysis was performed on vessel cross\u2010sections to assess collagen and elastin contents.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results:<\/jats:title><jats:p>Although pressure\u2010dependent tone decreased significantly during ageing, differences between groups were abolished by<jats:styled-content style=\"fixed-case\">NOS<\/jats:styled-content>inhibition. Vessel diameters increased in adult vs. young rats (at 90\u00a0mmHg, 233\u00a0\u00b1\u00a06.0\u00a0\u03bcm vs. 192\u00a0\u00b1\u00a04.5\u00a0\u03bcm;<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.05), possibly secondary to somatic growth. Further ageing was associated with reductions in lumen diameter (207\u00a0\u00b1\u00a06.5\u00a0\u03bcm;<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.05), increased wall and media thickness (and wall\/lumen ratio) and cross\u2010sectional area. Distensibility and wall collagen were unchanged, although elastin content was significantly reduced.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions:<\/jats:title><jats:p>Maturation is associated with differences in<jats:styled-content style=\"fixed-case\">PCA<\/jats:styled-content>dimensional properties that indicate a pattern of initial outward eutrophic, followed by inward hypertrophic remodelling. Functionally, the contribution of basal<jats:styled-content style=\"fixed-case\"><jats:roman>NO<\/jats:roman><\/jats:styled-content>increases with age in a way that reduces pressure\u2010dependent tone and diminishes vasodilator reserve.<\/jats:p><\/jats:sec>","DOI":"10.1111\/j.1748-1716.2011.02406.x","type":"journal-article","created":{"date-parts":[[2011,12,27]],"date-time":"2011-12-27T03:41:35Z","timestamp":1324957295000},"page":"363-371","source":"Crossref","is-referenced-by-count":22,"title":["Maturation is associated with changes in rat cerebral artery structure, biomechanical properties and tone"],"prefix":"10.1111","volume":"205","author":[{"given":"M.","family":"Mandal\u00e0","sequence":"first","affiliation":[{"name":"Department of Cell Biology University of Calabria Arcavacata di Rende Italy"},{"name":"Department of Obstretrics and Gynecology University of Vermont Burlington VT USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A. 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