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Exercise training is known to confer protection against diseases with chronic inflammation by reducing inflammatory response in human or experimental animals. In this study, we investigated the preventive effect of exercise training against lung inflammation induced by environmental <jats:styled-content style=\"fixed-case\">CS<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods and results<\/jats:title><jats:p>In this study, two groups of mice received air exposure with (the exercise group) or without (the control group) exercise training for 8\u00a0weeks and another two groups received air exposure for the first 4\u00a0weeks and <jats:styled-content style=\"fixed-case\">CS<\/jats:styled-content> exposure for the following 4\u00a0weeks with (the exercise+<jats:styled-content style=\"fixed-case\">CS<\/jats:styled-content> group) or without (the <jats:styled-content style=\"fixed-case\">CS<\/jats:styled-content> group) exercise training for 8\u00a0weeks. As compared with lung tissues of control and exercise groups, those of the <jats:styled-content style=\"fixed-case\">CS<\/jats:styled-content> group showed significantly increased bronchoalveolar\u2010capillary permeability, inflammatory cell infiltration, epithelial thickening, expression of proliferating cell nuclear antigen, mucin 2, cytokines, chemokines, adhesion molecules and activation of <jats:styled-content style=\"fixed-case\">NF<\/jats:styled-content>\u2010\u03ba<jats:styled-content style=\"fixed-case\">B<\/jats:styled-content>. These <jats:styled-content style=\"fixed-case\">CS<\/jats:styled-content>\u2010induced pathophysiologic consequences were largely prevented in the exercise\u00a0+\u00a0<jats:styled-content style=\"fixed-case\">CS<\/jats:styled-content> group.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Collectively, prior exercise training may protect against lung inflammation induced by environmental <jats:styled-content style=\"fixed-case\">CS<\/jats:styled-content> in mice by attenuating the activation of <jats:styled-content style=\"fixed-case\">NF<\/jats:styled-content>\u2010\u03ba<jats:styled-content style=\"fixed-case\">B<\/jats:styled-content> and the production of inflammatory mediators.<\/jats:p><\/jats:sec>","DOI":"10.1111\/j.1748-1716.2012.02433.x","type":"journal-article","created":{"date-parts":[[2012,3,27]],"date-time":"2012-03-27T00:58:24Z","timestamp":1332809904000},"page":"532-540","source":"Crossref","is-referenced-by-count":27,"title":["Prior exercise training alleviates the lung inflammation induced by subsequent exposure to environmental cigarette smoke"],"prefix":"10.1111","volume":"205","author":[{"given":"Y.\u2010B.","family":"Yu","sequence":"first","affiliation":[{"name":"Department of Physiology School of Medicine, National Yang\u2010Ming University Taipei Taiwan"},{"name":"Division of Hematology and Oncology, Department of Medicine Taipei Veterans General Hospital Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y.\u2010W.","family":"Liao","sequence":"additional","affiliation":[{"name":"Department of Physiology School of Medicine, National Yang\u2010Ming University Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K.\u2010H.","family":"Su","sequence":"additional","affiliation":[{"name":"Department of Physiology School of Medicine, National Yang\u2010Ming University Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T.\u2010M.","family":"Chang","sequence":"additional","affiliation":[{"name":"Department of Physiology School of Medicine, National Yang\u2010Ming University Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.\u2010K.","family":"Shyue","sequence":"additional","affiliation":[{"name":"Cardiovascular Division Institute of Biomedical Sciences, Academia Sinica Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y. 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