{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T00:38:58Z","timestamp":1791247138310,"version":"4.1.0"},"reference-count":33,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2012,4,10]],"date-time":"2012-04-10T00:00:00Z","timestamp":1334016000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acta Physiologica"],"published-print":{"date-parts":[[2012,8]]},"abstract":"Abstract<\/jats:title>Aim<\/jats:title>Alpha\u2010thalassaemia is known to reduce intra\u2010erythrocyte H<\/jats:styled-content>bS<\/jats:styled-content> (sickle haemoglobin) concentration in sickle cell trait (SCT<\/jats:styled-content>) subjects. Because H<\/jats:styled-content>bS<\/jats:styled-content> was shown to increase oxidative stress, the purpose of this study was to assess the effects of the coexistence of \u03b1\u2010thalassaemia and SCT<\/jats:styled-content> on oxidative stress markers and nitric oxide (NO<\/jats:styled-content>) metabolism after an acute physical exercise.<\/jats:p><\/jats:sec>Methods<\/jats:title>Forty subjects (age: 23.5\u00a0\u00b1\u00a02.21\u00a0years), SCT<\/jats:styled-content> carriers (H<\/jats:styled-content>bAS<\/jats:styled-content>) or healthy subjects (H<\/jats:styled-content>bAA<\/jats:styled-content>), with (\u2010\u03b1T<\/jats:styled-content>) or without (\u2010N<\/jats:styled-content>\u03b1T<\/jats:styled-content>) an associated \u03b1\u2010thalassaemia took part in the study. Plasma markers of oxidative stress [advanced oxidation protein products (AOPP<\/jats:styled-content>), protein carbonyl, malondialdehyde (MDA<\/jats:styled-content>) and nitrotyrosine], anti\u2010oxidant defences and NO<\/jats:styled-content> metabolism (NO<\/jats:styled-content>x) were measured at rest (T<\/jats:styled-content>rest<\/jats:sub>), immediately following an incremental maximal exercise test (T<\/jats:styled-content>ex<\/jats:sub>) and during recovery (T<\/jats:styled-content>1h<\/jats:sub>, T<\/jats:styled-content>2h<\/jats:sub> and T<\/jats:styled-content>24h<\/jats:sub>).<\/jats:p><\/jats:sec>Results<\/jats:title>Malondialdehyde expressed as the percentage of changes from baseline was significantly higher in the H<\/jats:styled-content>bAS<\/jats:styled-content>\u2010N<\/jats:styled-content>\u03b1T<\/jats:styled-content> compared with H<\/jats:styled-content>bAS<\/jats:styled-content>\u2010\u03b1T<\/jats:styled-content> during recovery (+36.3\u00a0\u00b1\u00a014.1% vs. \u22121.8\u00a0\u00b1\u00a013.2% at T<\/jats:styled-content>1h<\/jats:sub>, P\u00a0<\/jats:italic>=\u00a0<\/jats:italic>0.02; +36.6\u00a0\u00b1\u00a013.4% vs. \u221211.4\u00a0\u00b1\u00a012.5% at T<\/jats:styled-content>2h<\/jats:sub>, P\u00a0<\/jats:italic>=\u00a0<\/jats:italic>0.004 and +24.1\u00a0\u00b1\u00a012.3% vs. \u221214.4\u00a0\u00b1\u00a011.5% at T<\/jats:styled-content>24h<\/jats:sub>, P\u00a0<\/jats:italic>=\u00a0<\/jats:italic>0.02 in H<\/jats:styled-content>bAS<\/jats:styled-content>\u2010N<\/jats:styled-content>\u03b1T<\/jats:styled-content> vs. H<\/jats:styled-content>bAS<\/jats:styled-content>\u2010\u03b1T<\/jats:styled-content>). Compared with H<\/jats:styled-content>bAS<\/jats:styled-content>\u2010N<\/jats:styled-content>\u03b1T<\/jats:styled-content>, H<\/jats:styled-content>bAS<\/jats:styled-content>\u2010\u03b1T<\/jats:styled-content> had a higher NO<\/jats:styled-content>x change from baseline at T<\/jats:styled-content>ex<\/jats:sub> (\u221223.4\u00a0\u00b1\u00a020.6% vs. +57.7\u00a0\u00b1\u00a019.3%, respectively; P\u00a0<\/jats:italic>=\u00a0<\/jats:italic>0.005) and lower nitrotyrosine change from baseline at T<\/jats:styled-content>1h<\/jats:sub> (+7.2\u00a0\u00b1\u00a022.2% vs. +93.5%\u00b129.3%, respectively; P\u00a0<\/jats:italic>=\u00a0<\/jats:italic>0.04).<\/jats:p><\/jats:sec>Conclusion<\/jats:title>All these data suggest that the presence of \u03b1\u2010thalassaemia may blunt the higher level of oxidative stress and the impaired bioavailability of NO<\/jats:styled-content> observed in the SCT<\/jats:styled-content> carriers.<\/jats:p><\/jats:sec>","DOI":"10.1111\/j.1748-1716.2012.02434.x","type":"journal-article","created":{"date-parts":[[2012,3,12]],"date-time":"2012-03-12T16:23:13Z","timestamp":1331569393000},"page":"541-550","source":"Crossref","is-referenced-by-count":19,"title":["Effect of \u03b1\u2010thalassaemia on exercise\u2010induced oxidative stress in sickle cell trait"],"prefix":"10.1111","volume":"205","author":[{"given":"C.","family":"Fa\u0451s","sequence":"first","affiliation":[{"name":"Center of Research and Innovation on Sports (CRIS EA647) University Claude Bernard Lyon 1 University of Lyon Lyon France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Martin","sequence":"additional","affiliation":[{"name":"Center of Research and Innovation on Sports (CRIS EA647) University Claude Bernard Lyon 1 University of Lyon Lyon France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E. 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