{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,18]],"date-time":"2026-03-18T04:27:09Z","timestamp":1773808029173,"version":"3.50.1"},"reference-count":42,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2012,5,4]],"date-time":"2012-05-04T00:00:00Z","timestamp":1336089600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acta Physiologica"],"published-print":{"date-parts":[[2012,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>Hypoxic pulmonary vasoconstriction (<jats:styled-content style=\"fixed-case\">HPV<\/jats:styled-content>) causes pulmonary hypertension that may lead to right heart failure. We hypothesized that the <jats:styled-content style=\"fixed-case\">COX<\/jats:styled-content>\u20102 inhibitor nimesulide and the thromboxane <jats:styled-content style=\"fixed-case\">A<\/jats:styled-content><jats:sub>2<\/jats:sub> receptor antagonist daltroban would attenuate <jats:styled-content style=\"fixed-case\">HPV<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Haemodynamic measurements and blood sampling were performed in 18 anaesthetized, mechanically ventilated pigs, with mean\u00a0\u00b1\u00a0<jats:styled-content style=\"fixed-case\">SEM<\/jats:styled-content> weights of 31.3\u00a0\u00b1\u00a00.6\u00a0kg, in normoxia (<jats:styled-content style=\"fixed-case\">F<\/jats:styled-content><jats:sub>i<\/jats:sub><jats:styled-content style=\"fixed-case\">O<\/jats:styled-content><jats:sub>2<\/jats:sub>~0.21) and hypoxia (<jats:styled-content style=\"fixed-case\">F<\/jats:styled-content><jats:sub>i<\/jats:sub><jats:styled-content style=\"fixed-case\">O<\/jats:styled-content><jats:sub>2<\/jats:sub>~0.10), before and 5, 15 and 45\u00a0min after initiation of right atrial infusion of nimesulide (<jats:italic>n<\/jats:italic>\u00a0=\u00a06) or daltroban (<jats:italic>n<\/jats:italic>\u00a0=\u00a06), respectively, and in six control pigs.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Compared with normoxia, hypoxia (<jats:italic>n<\/jats:italic>\u00a0=\u00a018) increased mean pulmonary artery pressure by 15.8\u00a0\u00b1\u00a00.8\u00a0mmHg (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001), pulmonary vascular resistance (<jats:styled-content style=\"fixed-case\">PVR<\/jats:styled-content>) by 2.7\u00a0\u00b1\u00a00.3 <jats:styled-content style=\"fixed-case\">WU<\/jats:styled-content> (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.05) and mean right atrial pressure by 2.3\u00a0\u00b1\u00a00.3\u00a0mmHg (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001). In the control pigs, mean pulmonary artery pressure, <jats:styled-content style=\"fixed-case\">PVR<\/jats:styled-content> and mean right atrial pressure remained stable (<jats:italic>P<\/jats:italic>\u00a0=\u00a0ns) throughout 45\u00a0min hypoxia, compared with hypoxia baseline. Nimesulide decreased mean pulmonary artery pressure by 3.7\u00a0\u00b1\u00a01.3\u00a0mmHg after 45\u00a0min (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.013), as well as <jats:styled-content style=\"fixed-case\">PVR<\/jats:styled-content> by 0.8\u00a0\u00b1\u00a00.2 <jats:styled-content style=\"fixed-case\">WU<\/jats:styled-content> (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.05), levelling off after 15\u00a0min. Daltroban transiently increased (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001) mean pulmonary artery pressure and mean right atrial pressure by 7.2\u00a0\u00b1\u00a01.2 and 2.7\u00a0\u00b1\u00a00.4\u00a0mmHg, respectively, but they returned to hypoxia baseline (<jats:italic>P<\/jats:italic>\u00a0=\u00a0ns) within 5\u00a0min. <jats:styled-content style=\"fixed-case\">D<\/jats:styled-content>altroban then decreased mean pulmonary artery pressure to after 45\u00a0min be 4.2\u00a0\u00b1\u00a01.6\u00a0mmHg lower (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.005) than at hypoxia baseline.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p><jats:styled-content style=\"fixed-case\">COX<\/jats:styled-content>\u20102 inhibition and thromboxane A<jats:sub>2<\/jats:sub> receptor antagonism attenuate <jats:styled-content style=\"fixed-case\">HPV<\/jats:styled-content> by decreasing mean pulmonary artery pressure by approximately 10\u201311%, as measured 45\u00a0min after initiation of nimesulide or daltroban infusion respectively.<\/jats:p><\/jats:sec>","DOI":"10.1111\/j.1748-1716.2012.02437.x","type":"journal-article","created":{"date-parts":[[2012,5,4]],"date-time":"2012-05-04T09:48:21Z","timestamp":1336124901000},"page":"507-519","source":"Crossref","is-referenced-by-count":15,"title":["Cyclooxygenase\u20102 inhibition and thromboxane <scp>A<\/scp><sub>2<\/sub> receptor antagonism attenuate hypoxic pulmonary vasoconstriction in a porcine model"],"prefix":"10.1111","volume":"205","author":[{"given":"D.","family":"Kylhammar","sequence":"first","affiliation":[{"name":"The \u00d6resund Cardiovascular Research Collaboration The Clinic for Heart Failure and Valvular Disease Sk\u00e5ne University Hospital Lund Sweden"},{"name":"Department of Cardiology Lund University Lund Sweden"},{"name":"The Copenhagen Muscle Research Centre Rigshospitalet and the Panum Institute University of Copenhagen Copenhagen Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G.","family":"R\u00e5degran","sequence":"additional","affiliation":[{"name":"The \u00d6resund Cardiovascular Research Collaboration The Clinic for Heart Failure and Valvular Disease Sk\u00e5ne University Hospital Lund Sweden"},{"name":"Department of Cardiology Lund University Lund Sweden"},{"name":"The Copenhagen Muscle Research Centre Rigshospitalet and the Panum Institute University of Copenhagen Copenhagen Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2012,5,4]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1569-9048(02)00053-8"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1164\/arrd.1983.127.1.59"},{"key":"e_1_2_8_4_1","first-page":"903","article-title":"Prostaglandin synthesis inhibition restores hypoxic pulmonary vasoconstriction","volume":"42","author":"Alexander J.M.","year":"1977","journal-title":"J Appl Physiol Respirat Environ Exercise Physiol"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/0022-3468(86)90018-7"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/0090-6980(87)90291-7"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000084536.87322.BB"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00195.2005"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.106.650796"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1476-5381.1995.tb16341.x"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/PL00005077"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1203\/00006450-198909000-00002"},{"key":"e_1_2_8_13_1","first-page":"433","article-title":"Hypoxic pulmonary vasoconstriction in isolated blood\u2010perfused rat lung; 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