{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,22]],"date-time":"2026-01-22T07:39:10Z","timestamp":1769067550087,"version":"3.49.0"},"reference-count":30,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2001,8,1]],"date-time":"2001-08-01T00:00:00Z","timestamp":996624000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Small Animal Practice"],"published-print":{"date-parts":[[2001,8]]},"abstract":"<jats:p>Six dogs with partial seizures or partial seizure\u2010like activity were treated with the antiepileptic drug felbamate between 1993 and 1998. All dogs had a history and results of diagnostic testing suggestive of either primary (idiopathic) or occult secondary epilepsy. Dogs ranged between four months and eight years of age at the onset of seizure activity. The median time period between onset of the first seizure and the start of felbamate therapy was 3\u20138 months (range 0\u201375 to 36 months). Median duration of therapy was nine months (range two to 22 months). All dogs experienced a reduction in seizure frequency after felbamate administration. Median total number of seizures post\u2010treatment was two (range 0 to 9). Two dogs had an immediate and prolonged cessation of seizure activity. Steady\u2010state trough serum felbamate concentrations measured at two weeks, and one, 12 and 22 months after the commencement of therapy in four dogs ranged between 13 and 55 mg\/litre (median 35 mg\/litre). Reversible haematological adverse effects were detected in two dogs, with one dog developing concurrent keratoconjunctivitis sicca. These results suggest that felbamate can be an effective antiepileptic drug without life\u2010threatening complications when used as monotherapy for partial seizures in the dog.<\/jats:p>","DOI":"10.1111\/j.1748-5827.2001.tb02490.x","type":"journal-article","created":{"date-parts":[[2008,4,10]],"date-time":"2008-04-10T14:13:23Z","timestamp":1207836803000},"page":"403-408","source":"Crossref","is-referenced-by-count":22,"title":["Treatment of partial seizures and seizure\u2010like activity with felbamate in six dogs"],"prefix":"10.1111","volume":"42","author":[{"given":"D.","family":"Ruehlmann","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Podell","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P.","family":"March","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2001,8]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1528-1157.1992.tb02206.x"},{"key":"e_1_2_1_3_1","first-page":"427","volume-title":"Epilepsy: A Comprehensive Textbook","author":"Avanzini G.","year":"1997"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1939-1676.1999.tb02159.x"},{"key":"e_1_2_1_5_1","first-page":"779","volume-title":"Epilepsy: A Comprehensive Textbook","author":"Blume W. 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